Facemap: a framework for modeling neural activity based on orofacial tracking
Nature Neuroscience,
Journal Year:
2023,
Volume and Issue:
27(1), P. 187 - 195
Published: Nov. 20, 2023
Recent
studies
in
mice
have
shown
that
orofacial
behaviors
drive
a
large
fraction
of
neural
activity
across
the
brain.
To
understand
nature
and
function
these
signals,
we
need
better
computational
models
to
characterize
relate
them
activity.
Here
developed
Facemap,
framework
consisting
keypoint
tracker
deep
network
encoder
for
predicting
Our
algorithm
tracking
mouse
was
more
accurate
than
existing
pose
estimation
tools,
while
processing
speed
several
times
faster,
making
it
powerful
tool
real-time
experimental
interventions.
The
Facemap
easy
adapt
data
from
new
labs,
requiring
as
few
10
annotated
frames
near-optimal
performance.
We
used
keypoints
inputs
which
predicts
~50,000
simultaneously-recorded
neurons
and,
visual
cortex,
doubled
amount
explained
variance
compared
previous
methods.
Using
this
model,
found
neuronal
clusters
were
well
predicted
behavior
spatially
spread
out
cortex.
also
behavioral
features
model
had
stereotypical,
sequential
dynamics
not
reversible
time.
In
summary,
provides
stepping
stone
toward
understanding
brain-wide
signals
their
relation
behavior.
Language: Английский
Hippocampal neuronal activity is aligned with action plans
Nature,
Journal Year:
2025,
Volume and Issue:
639(8053), P. 153 - 161
Published: Jan. 8, 2025
Language: Английский
Toward a neuroscience of natural behavior
Current Opinion in Neurobiology,
Journal Year:
2024,
Volume and Issue:
86, P. 102859 - 102859
Published: April 6, 2024
One
of
the
most
exciting
new
developments
in
systems
neuroscience
is
progress
being
made
toward
neurophysiological
experiments
that
move
beyond
simplified
laboratory
settings
and
address
richness
natural
behavior.
This
enabled
by
technological
advances
such
as
wireless
recording
freely
moving
animals,
automated
quantification
behavior,
methods
for
analyzing
large
data
sets.
Beyond
empirical
data,
however,
there
also
a
need
theories
concepts
to
interpret
data.
Such
particular
challenges
which
often
differ
significantly
from
scenarios
studied
traditional
settings.
Here,
we
discuss
some
strategies
developing
novel
example
hypotheses
proposed.
Language: Английский
Convergent vocal representations in parrot and human forebrain motor networks
Nature,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Language: Английский
Analysis methods for large-scale neuronal recordings
Science,
Journal Year:
2024,
Volume and Issue:
386(6722)
Published: Nov. 7, 2024
Simultaneous
recordings
from
hundreds
or
thousands
of
neurons
are
becoming
routine
because
innovations
in
instrumentation,
molecular
tools,
and
data
processing
software.
Such
can
be
analyzed
with
science
methods,
but
it
is
not
immediately
clear
what
methods
to
use
how
adapt
them
for
neuroscience
applications.
We
review,
categorize,
illustrate
diverse
analysis
neural
population
describe
these
have
been
used
make
progress
on
longstanding
questions
neuroscience.
review
a
variety
approaches,
ranging
the
mathematically
simple
complex,
exploratory
hypothesis-driven,
recently
developed
more
established
methods.
also
some
common
statistical
pitfalls
analyzing
large-scale
data.
Language: Английский
Experience reorganizes content-specific memory traces in macaques
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Abstract
Memory
formation
requires
neural
activity
reorganization
during
experience
that
persists
in
sleep.
How
these
processes
promote
learning
while
preserving
established
memories
remains
unclear.
We
recorded
ensemble
from
hippocampal
and
associated
regions
freely
moving
macaques
as
they
recalled
item
sequences
presented
day
(“new”),
one
prior
(“recent”),
or
over
two
weeks
(“old”).
Cell
assemblies
biased
for
old
showed
less
drift,
greater
network
connectivity,
stronger
sleep
reactivation
than
new-biased
assemblies.
Pairs
of
recent
formed
persistent
task-to-sleep
coupling
(“metassemblies”),
unlike
new
assembly
pairs.
In
the
hippocampus,
propensity
superficial
deep
CA1
pyramidal
cells
to
form
integrated
increased
with
memory
age.
These
findings
reveal
rapid
organization
stabilization
primate
brain,
suggesting
potential
mechanisms
balancing
linking
durability.
Language: Английский
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
eLife,
Journal Year:
2024,
Volume and Issue:
13
Published: Jan. 23, 2024
The
flow
of
neural
activity
across
the
neocortex
during
active
sensory
discrimination
is
constrained
by
task-specific
cognitive
demands,
movements,
and
internal
states.
During
behavior,
brain
appears
to
sample
from
a
broad
repertoire
activation
motifs.
Understanding
how
these
patterns
local
global
are
selected
in
relation
both
spontaneous
task-dependent
behavior
requires
in-depth
study
densely
sampled
at
single
neuron
resolution
large
regions
cortex.
In
significant
advance
toward
this
goal,
we
developed
procedures
record
mesoscale
2-photon
Ca2+
imaging
data
two
novel
vivo
preparations
that,
between
them,
allow
for
simultaneous
access
nearly
all
0f
mouse
dorsal
lateral
neocortex.
As
proof
principle,
aligned
with
behavioral
primitives
high-level
motifs
reveal
existence
populations
neurons
that
coordinated
their
cortical
areas
changes
movement
and/or
arousal.
methods
detail
here
facilitate
identification
exploration
widespread,
spatially
heterogeneous
ensembles
whose
related
diverse
aspects
behavior.
Language: Английский
Reward Expectation Reduces Representational Drift in the Hippocampus
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 22, 2023
Spatial
memory
in
the
hippocampus
involves
dynamic
neural
patterns
that
change
over
days,
termed
representational
drift.
While
drift
may
aid
updating,
excessive
could
impede
retrieval.
Memory
retrieval
is
influenced
by
reward
expectation
during
encoding,
so
we
hypothesized
diminished
would
exacerbate
We
found
high
limited
drift,
with
CA1
representations
on
one
day
gradually
re-emerging
successive
trials
following
day.
Conversely,
absence
of
resulted
increased
as
gradual
re-emergence
previous
day's
representation
did
not
occur.
At
single
cell
level,
lowering
caused
an
immediate
increase
proportion
place-fields
low
trial-to-trial
reliability.
These
place
fields
were
less
likely
to
be
reinstated
day,
underlying
this
condition.
In
conclusion,
heightened
improves
encoding
and
maintaining
reliable
are
across
thereby
minimizing
Language: Английский
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 23, 2023
The
flow
of
neural
activity
across
the
neocortex
during
active
sensory
discrimination
is
constrained
by
task-specific
cognitive
demands,
movements,
and
internal
states.
During
behavior,
brain
appears
to
sample
from
a
broad
repertoire
activation
motifs.
Understanding
how
these
patterns
local
global
are
selected
in
relation
both
spontaneous
task-dependent
behavior
requires
in-depth
study
densely
sampled
at
single
neuron
resolution
large
regions
cortex.
In
significant
advance
toward
this
goal,
we
developed
procedures
record
mesoscale
2-photon
Ca
Language: Английский