Analysis of Volatile Compounds in Citri grandis from Different Regions in South China and the Response of Volatile Compounds to Ecological Factors DOI Creative Commons
Songnian Hu, Ao Zhang, Hao Wu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 622 - 622

Published: Jan. 31, 2025

Citri grandis Exocarpium (Chinese name Huajuhong, HJH) is a traditional Chinese medicinal herb widely used in medicines and foods China due to its efficacy treating coughs excessive phlegm. This study employed HS-SPME-GC-MS analyze the volatile compounds HJH samples from different regions, with aim of distinguishing Huazhou those other origins exploring their potential relationship ecological factors. A multidimensional strategy was utilized relationships between oils, climatic factors, soil elements, examining how responded From 47 batches across various eight significantly were identified, serving as chemical markers for Huazhou. The findings elucidate impact factors on HJH, highlighting environmental relating authenticity results indicate that shaped by unique environments

Language: Английский

Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity DOI
Nan Shen, Tongfei Wang, Quan Gan

et al.

Food Chemistry, Journal Year: 2022, Volume and Issue: 383, P. 132531 - 132531

Published: Feb. 23, 2022

Language: Английский

Citations

1247
The Structure and Function of Major Plant Metabolite Modifications DOI Creative Commons
Shouchuang Wang, Saleh Alseekh, Alisdair R. Fernie

et al.

Molecular Plant, Journal Year: 2019, Volume and Issue: 12(7), P. 899 - 919

Published: June 11, 2019

Language: Английский

Citations

342
Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development DOI Creative Commons
Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(3), P. 762 - 762

Published: Feb. 10, 2020

Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning nervous system rather than only symptom. In fact, significant social, health, and economic burden worldwide. Flavonoids are plant derivative compounds easily found in several fruits vegetables consumed daily food intake. vary terms classes, while structurally unique, they share basic structure formed by three rings, known as flavan nucleus. Structural differences pattern substitution one these rings. The hydroxyl group (–OH) position rings determines mechanisms action flavonoids reveals complex multifunctional activity. have been widely used for their antioxidant, analgesic, anti-inflammatory effects along with safe preclinical clinical profiles. this review, we discuss evidence on analgesic proprieties flavonoids. We also focus how development formulations containing flavonoids, understanding structure-activity relationship, harnessed to identify novel flavonoid-based therapies treat inflammation.

Language: Английский

Citations

254
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies DOI Open Access

Gopalsamy Rajiv Gandhi,

Alan Bruno Silva Vasconcelos, Ding‐Tao Wu

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(10), P. 2907 - 2907

Published: Sept. 23, 2020

The consumption of plant-based food is important for health promotion, especially concerning the prevention and management chronic diseases. Flavonoids are main bioactive compounds in citrus fruits, with multiple beneficial effects, antidiabetic effects. We systematically review potential action molecular mechanisms flavonoids based on vitro vivo studies. A search PubMed, EMBASE, Scopus, Web Science Core Collection databases articles published since 2010 was carried out using keywords citrus, flavonoid, diabetes. All identified were analyzed, data extracted a standardized form. 38 articles, which reported that 19 flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, xanthohumol, have potential. These regulated biomarkers glycemic control, lipid profiles, renal function, hepatic enzymes, antioxidant modulated signaling pathways related to glucose uptake insulin sensitivity involved pathogenesis diabetes its complications. Citrus therefore, promising candidates, while their effects remain be verified forthcoming human

Language: Английский

Citations

208
Bioactive flavonoids in Moringa oleifera and their health-promoting properties DOI

Mengfei Lin,

Junjie Zhang,

Xiaoyang Chen

et al.

Journal of Functional Foods, Journal Year: 2018, Volume and Issue: 47, P. 469 - 479

Published: June 19, 2018

Language: Английский

Citations

182
Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives DOI Creative Commons
Shuangqian Shen, Chuansong Zhan, Chenkun Yang

et al.

Molecular Plant, Journal Year: 2022, Volume and Issue: 16(1), P. 43 - 63

Published: Sept. 16, 2022

Language: Английский

Citations

152
Three AP2/ERF family members modulate flavonoid synthesis by regulating type IV chalcone isomerase in citrus DOI
Chenning Zhao, Xiaojuan Liu,

Qin Gong

et al.

Plant Biotechnology Journal, Journal Year: 2020, Volume and Issue: 19(4), P. 671 - 688

Published: Oct. 22, 2020

Summary Flavanones and flavones are excellent source of bioactive compounds but the molecular basis their highly efficient production remains elusive. Chalcone isomerase (CHI) family proteins play essential roles in flavonoid biosynthesis little known about transcription factors controlling gene expression. Here, we identified a type IV CHI (designated as CitCHIL1) from citrus which enhances accumulation flavanones (CFLs). CitCHIL1 participates CFL biosynthetic metabolon assists cyclization naringenin chalcone to ( 2S )‐naringenin, leads influx substrates synthase (CHS) improves catalytic efficiency CHS. Overexpressing Citrus Arabidopsis significantly increased content RNA interference‐induced silencing led 43% reduction content. Three AP2/ERF were positive regulators Of these, two dehydration‐responsive element binding (DREB) proteins, CitERF32 CitERF33, activated by directly CGCCGC motif promoter, while CitRAV1 (RAV: related ABI3/VP1) formed complex with CitERF33 that strongly enhanced activation accumulation. These results not only illustrate specific function executes also reveal new DREB‐RAV transcriptional regulating production.

Language: Английский

Citations

145
Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways DOI Creative Commons
Manuel Humberto Cháirez‐Ramírez, Karen Griselda de la Cruz-López, Alejandro Garcı́a-Carrancá

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 20, 2021

Polyphenols constitute an important group of natural products that are traditionally associated with a wide range bioactivities. These usually found in low concentrations and now available nutraceuticals or dietary supplements. A polyphenols include apigenin, quercetin, curcumin, resveratrol, EGCG, kaempferol have been shown to regulate signaling pathways central for cancer development, progression, metastasis. Here, we describe novel mechanistic insights on the effect this key elements impacting cancer. We protein modifications induced by these their several including PI3K, Akt, mTOR, RAS, MAPK particularly those affecting tumor suppressor p53 protein. Modifications gene expression levels posttranslational such as phosphorylation, acetylation, ubiquitination influence stability, subcellular location, activation new transcriptional targets, role response DNA damage, apoptosis control, cell- cycle regulation, senescence, cell fate. Thus, deep understanding effects players cancer-driving will certainly lead better designed targeted therapies, less toxicity treatment. The scope review centers regulation most studied highlights importance profound regulations order improve treatment control products.

Language: Английский

Citations

145
Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages DOI

Xingmiao Lu,

Chengying Zhao, Huan Shi

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 63(14), P. 2018 - 2041

Published: Oct. 5, 2021

Citrus fruits are consumed in large quantities worldwide due to their attractive aromas and taste, as well high nutritional values various health-promoting effects, which abundance of nutrients bioactives. In addition water, carbohydrates, vitamins, minerals, dietary fibers important citrus, providing them with values. also rich bioactives such flavonoids, essential oils, carotenoids, limonoids, synephrines, protect from ailments, including cancer inflammatory, digestive, cardiovascular diseases. The composition content differ significantly among citrus varieties, fruit parts, growth stages. To better understand the nutrient bioactive profiles provide guidance for utilization high-value resources, this review systematically summarizes fruit, contents, structural characteristics, potential health benefits. We explore variation different stages, effects applications.

Language: Английский

Citations

132
An Overview of Bioactive Flavonoids from Citrus Fruits DOI Creative Commons
Mohamed Addi, Amine Elbouzidi, Malika Abid

et al.

Applied Sciences, Journal Year: 2021, Volume and Issue: 12(1), P. 29 - 29

Published: Dec. 21, 2021

Citrus species are one of the world’s popular fruit crops, cultivated all over world for their economic and nutritional values. Citrus, like other fruits vegetables, an important source several antioxidant molecules (polyphenols, ascorbic acid, carotenoids) that can inhibit harmful effects free radicals on human body; due to functional values health-promoting properties, considered valuable not only in agri-food industry, but also pharmaceutical industry. Flavonoids among major constituents polyphenols found different parts (skin, peels, seed, pulp membrane, juice). have biological properties (antiviral, antifungal, antibacterial activities). Several studies shown health-related flavonoids, especially antioxidant, anticancer, anti-inflammation, anti-aging, cardiovascular protection activities. In present review, attempts made discuss current trends research flavonoids species.

Language: Английский

Citations

111