Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 340 - 340

Published: Dec. 25, 2022

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, tissue-protective properties which may be useful treatment various diseases, particularly cancer, neurological, cardiovascular, respiratory, metabolic disorders. This article reviews current information on biological effects above-mentioned disorders relation molecular pathways controlling inflammation, oxidative stress, apoptosis.

Language: Английский

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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1224 - 1224

Published: June 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Language: Английский

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Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

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Quercetin, a Flavonoid with Great Pharmacological Capacity

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1000 - 1000

Published: Feb. 25, 2024

Quercetin is a flavonoid with low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. has potent antioxidant capacity, being able capture reactive oxygen species (ROS), nitrogen (RNS), chlorine (ROC), which act as reducing agents by chelating transition-metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its different pharmacological properties of quercetin have been described, such carcinostatic properties; antiviral, antihypertensive, anti-inflammatory ability protect low-density lipoprotein (LDL) oxidation, inhibit angiogenesis; these developed in this review.

Language: Английский

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Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1566 - 1566

Published: Aug. 13, 2022

(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses wide variety actions. EGCG acts as strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates systems superoxide dismutase, catalase, or glutathione, and reduces abundant production nitric oxide metabolites by inducible synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, metabolic effects via modulation intracellular signaling cascades. Based on this knowledge, the use could be benefit in respiratory diseases with acute chronic inflammatory, oxidative, fibrotizing processes their pathogenesis. This article reviews current information biological those animal models has been administered, i.e., distress syndrome, infections, COVID-19, bronchial asthma, obstructive pulmonary disease, lung fibrosis, silicosis, cancer, hypertension, embolism, critically discusses effectiveness administration these disorders. For review, articles English language from PubMed database were used.

Language: Английский

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From Cocoa to Chocolate: Effect of Processing on Flavanols and Methylxanthines and Their Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14365 - 14365

Published: Nov. 18, 2022

Despite the health benefits associated with ingestion of bioactive compounds in cocoa, high concentrations polyphenols and methylxanthines raw cocoa beans negatively influence taste, confer astringency bitterness, affect stability digestibility products. It is, therefore, necessary to process develop characteristic color, flavor, reduce which are desirable Processing, however, affects composition quantities compounds, resulting modification health-promoting properties chocolate. In this advanced review, we sought better understand effect cocoa’s transformational into chocolate on methylxanthine mechanism action original flavanols methylxanthines. More data processing bioactives still needed for understanding each step final polyphenolic other Regarding mechanisms action, theobromine acts through modulation fatty acid metabolism, mitochondrial function, energy metabolism pathways, while mainly act though protein kinases antioxidant pathways. Both seem be involved nitric oxide neurotrophin regulation.

Language: Английский

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Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10244 - 10244

Published: Sept. 6, 2022

Polyphenols represent a structural class of mainly natural organic chemicals that contain multiple phenol units. The beneficial properties polyphenols have been extensively studied for their antitumor, anti-inflammatory, and antibacterial effects, but nowadays, medical applications are starting to be extended many other due prebiotic role impact on the microbiota. This review focused use in cancer treatment. Their antineoplastic effects demonstrated various studies when they were tested numerous lines some vivo models. A431 SCC13 human skin cell treated with EGCG presented reduced viability enhanced death inactivation β-catenin signaling. Additionally, resveratrol showed great potential against breast its ability exert both anti-estrogenic estrogenic (based concentration) because it has high affinity estrogen receptors ERα Erβ. can combined different classical cytostatic agents enhance therapeutic cells also protect healthy from aggressiveness antitumor drugs anti-inflammatory properties. For instance, curcumin reported reduce gastrointestinal toxicity associated chemotherapy. In case 5-FU-induced, by increasing intestinal permeability inhibiting mucosal damage. Co-administration doxorubicin induced liver cells. inhibit autophagic activity stop hepatoma Hep3B proliferation symbiotic approach is well-known practice including

Language: Английский

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Polyphenols: a route from bioavailability to bioactivity addressing potential health benefits to tackle human chronic diseases

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 3 - 38

Published: Oct. 19, 2022

Language: Английский

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The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1680 - 1680

Published: Jan. 14, 2023

Various literature data show how a diet rich in vegetables could reduce the incidence of several cancers due to contribution natural polyphenols contained them. Polyphenols are attributed multiple pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective and even anti-tumor properties. The mechanisms involved their action include signaling pathways modulation associated with cell proliferation, differentiation, migration, angiogenesis, metastasis death. Since dysregulation death processes is cancer etiopathology, compounds able kill cells be used new anticancer agents. Apoptosis, programmed form death, most potent defense against main mechanism by both chemotherapy agents polyphenols. aim this review provide an update on apoptotic molecular induced some representative polyphenol family members cells. This aspect particularly important because it may useful design therapeutic strategies involving adjuvants.

Language: Английский

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Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 275 - 275

Published: Jan. 13, 2023

Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head neck cancers, featuring high morbidity mortality. The available conventional treatments suffer from several adverse effects are often inefficient in terms their survival rates. Thus, seeking novel therapeutic agents adjuvants utmost importance for modern society. Natural polyphenolic compounds have recently emerged as promising chemopreventive anticancer agents. Specifically, natural compound resveratrol (RSV) has gained momentum this purpose. RSV useful treating OSCC due to its antiproliferative, antimetastatic, proapoptotic effects. Additionally, acts against tumor cells while synergically cooperating with chemotherapeutics, overcoming drug resistance phenomena. Despite these wide-spectrum effects, there few specific investigations regarding RSV’s animal models that consider different routes vehicles administration RSV. Interestingly, an injectable RSV-loaded liposome-based formulation was proven be effective both vitro vivo models, demonstrating development delivery systems systemic and/or loco-regional applications may turning point oral cancer treatment, leading benefits properties well targeted delivery. Given premises, review offers a comprehensive overview main derivative, polydatin (PD), OSCC-related lines aiming guide scientific community regard PD use treatment precancerous cancerous lesions.

Language: Английский

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