Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2018, Volume and Issue: 9(1), P. 22 - 22

Published: March 1, 2018

Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D the field regenerative medicine and engineering are limited by variety biomaterials that can be used this technology. Many researchers have developed novel compositions to enable their use methods. advantages fabricating using numerous, including ability create complex geometries, porosities, co-culture multiple cells, incorporate growth factors. In review, recently-developed different tissues discussed. Biomaterials categorized into ceramics, polymers, composites. Due nature methods, most ceramics combined with polymers enhance printability. Polymer-based printed mostly extrusion-based broader range medicine. goal is fabricate functional viable organs and, achieve this, methods need researched.

Language: Английский

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Hydrogel-based 3D bioprinting: A comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives

Applied Materials Today, Journal Year: 2019, Volume and Issue: 18, P. 100479 - 100479

Published: Oct. 9, 2019

Language: Английский

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Novel Biomaterials Used in Medical 3D Printing Techniques

Journal of Functional Biomaterials, Journal Year: 2018, Volume and Issue: 9(1), P. 17 - 17

Published: Feb. 7, 2018

The success of an implant depends on the type biomaterial used for its fabrication. An ideal material should be biocompatible, inert, mechanically durable, and easily moldable. ability to build patient specific implants incorporated with bioactive drugs, cells, proteins has made 3D printing technology revolutionary in medical pharmaceutical fields. A vast variety biomaterials are currently being printing, including metals, ceramics, polymers, composites. With continuous research progress there been a rapid growth applications manufacturing customized implants, prostheses, drug delivery devices, scaffolds tissue engineering regenerative medicine. current review focuses novel technologies clinical applications. Most common types technologies, fused deposition modeling, extrusion based bioprinting, inkjet, polyjet techniques, their applications, different by researchers, key limitations discussed detail.

Language: Английский

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Chitosan hydrogels in 3D printing for biomedical applications

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 260, P. 117768 - 117768

Published: Feb. 10, 2021

Language: Английский

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An Overview on Materials and Techniques in 3D Bioprinting Toward Biomedical Application

Engineered Regeneration, Journal Year: 2020, Volume and Issue: 2, P. 1 - 18

Published: Dec. 18, 2020

Three-dimensional (3D) bioprinting, an additive manufacturing based technique of biomaterials fabrication, is innovative and auspicious strategy in medical pharmaceutical fields. The ability producing regenerative tissues organs has made this technology a pioneer to the creation artificial multi-cellular tissues/organs. A broad variety currently being utilized 3D bioprinting as well multiple techniques employed by researchers. In review, we demonstrate most common novel further with introducing related that are commonly taking into account addition, attempt been accomplished hand over relevant application such tissue regeneration, cancer investigations, etc. presenting important works. main aim review paper emphasis on strengths limitations existence order carry out comparison through them.

Language: Английский

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3D printing applications in bone tissue engineering

Journal of Clinical Orthopaedics and Trauma, Journal Year: 2019, Volume and Issue: 11, P. S118 - S124

Published: Dec. 14, 2019

Language: Английский

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Physically cross-linked chitosan-based hydrogels for tissue engineering applications: A state-of-the-art review

European Polymer Journal, Journal Year: 2021, Volume and Issue: 145, P. 110176 - 110176

Published: Jan. 17, 2021

Language: Английский

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Temperature- and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 111, P. 110862 - 110862

Published: March 19, 2020

Language: Английский

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3D Printing and Electrospinning of Composite Hydrogels for Cartilage and Bone Tissue Engineering

Polymers, Journal Year: 2018, Volume and Issue: 10(3), P. 285 - 285

Published: March 8, 2018

Injuries of bone and cartilage constitute important health issues costing the National Health Service billions pounds annually, in UK only. Moreover, these damages can become cause disability loss function for patients with associated social costs diminished quality life. The biomechanical properties two tissues are massively different from each other they not uniform within same tissue due to specific anatomic location function. In this perspective, engineering (TE) has emerged as a promising approach address complexities regeneration. Tissue aims at developing temporary three-dimensional multicomponent constructs promote natural healing process. Biomaterials, such hydrogels, currently extensively studied their ability reproduce both ideal 3D extracellular environment growth have adequate mechanical load bearing. This review will focus on use manufacturing techniques, namely electrospinning printing, that present promise fabrication complex composite gels applications.

Language: Английский

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