Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand DOI Creative Commons

Karim Farmanpour-Kalalagh,

Arman Beyraghdar Kashkooli, Alireza Babaei

et al.

Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 7, 2022

Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual endoperoxide 1, 2, 4-trioxane ring. It derived from the herbal medicinal plant Artemisia annua and best known for its use in treatment of malaria. However, recent studies also indicate potential artemisinin related compounds, commonly referred to as artemisinins, combating viral infections, inflammation certain cancers. Moreover, different modes action artemisinins make these compounds potentially relevant challenges world faces COVID-19 pandemic. Initial positive effects or spp. extracts combat SARS-CoV-2 infection symptoms WHO-supervised clinical on are now progress. implementing multiple new uses will require effective solutions boost production, either by enhancing synthesis A. itself through biotechnological engineering alternative biosynthesis platforms. Because this renewed interest derivatives, here we review action, application diseases including COVID-19, future options production.

Language: Английский

Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force DOI Creative Commons
Ho Lee, Shotaro Chubachi, Ho Namkoong

et al.

BMC Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 12, 2022

We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth 50.7 [SD 13.9]) waves had lower mean age than those other waves. Patients first wave longer hospital stay (mean, 30.3 days 21.5], p < 0.0001), post-hospitalization complications, such as bacterial infections (21.3%, were also noticeable. In addition, there was an increase use drugs remdesivir/baricitinib/tocilizumab/steroids latter wave, exhibited greater number presenting symptoms, higher percentage required oxygen therapy at time admission. However, invasive mechanical ventilation highest mortality rate third wave.We identified clinical each up Japan. The associated severity on admission, rate, ventilation.

Language: Английский

Citations

38
Allosteric inhibitors of the main protease of SARS-CoV-2 DOI Creative Commons
Subodh Kumar Samrat, Jimin Xu, Xuping Xie

et al.

Antiviral Research, Journal Year: 2022, Volume and Issue: 205, P. 105381 - 105381

Published: July 11, 2022

Language: Английский

Citations

35
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective DOI Creative Commons
J. Carlos Menéndez

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 658 - 658

Published: Jan. 20, 2022

In spite of advances in vaccination, control the COVID-19 pandemic will require use pharmacological treatments against SARS-CoV2. Their development needs to consider existence two phases disease, namely viral infection and inflammatory stages. The main targets for antiviral therapeutic intervention are: (a) proteins, including spike (S) protein characteristic cover proteases charge processing polyprotein arising from genome translation; (b) host such as those involved processes related entry into cell release inside cell, elongation factor eEF1A importins. antivirals targeted at proteins is less developed but it has potential advantage not being affected by mutations virus therefore active all its variants. Regarding drugs that address hyperinflammatory phase disease triggered so-called cytokine storm, following strategies are particularly relevant: targeting JAK kinases; sphingosine kinase 2 inhibitors; (c) antibodies interleukin 6 or receptor; (d) traditional anti-inflammatory corticosteroids.

Language: Английский

Citations

32
Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences DOI
Kimiyasu Shiraki, Noriaki Sato, Kaoru Sakai

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 235, P. 108121 - 108121

Published: Feb. 2, 2022

Language: Английский

Citations

31
Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand DOI Creative Commons

Karim Farmanpour-Kalalagh,

Arman Beyraghdar Kashkooli, Alireza Babaei

et al.

Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 7, 2022

Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual endoperoxide 1, 2, 4-trioxane ring. It derived from the herbal medicinal plant Artemisia annua and best known for its use in treatment of malaria. However, recent studies also indicate potential artemisinin related compounds, commonly referred to as artemisinins, combating viral infections, inflammation certain cancers. Moreover, different modes action artemisinins make these compounds potentially relevant challenges world faces COVID-19 pandemic. Initial positive effects or spp. extracts combat SARS-CoV-2 infection symptoms WHO-supervised clinical on are now progress. implementing multiple new uses will require effective solutions boost production, either by enhancing synthesis A. itself through biotechnological engineering alternative biosynthesis platforms. Because this renewed interest derivatives, here we review action, application diseases including COVID-19, future options production.

Language: Английский

Citations

31