Interactions between neuroanatomy, cognition, and ecology in Anolis lizards DOI Open Access
Levi Storks

Published: May 1, 2021

The interactions between an organism and its environment are mediated by cognition, the substrates of which in brain. Cognition is ubiquitous across vertebrates, yet we still know very little about factors shaping evolution, particularly outside birds mammals. In natural environments, cognition likely impacts fitness. Behavioral flexibility, enables animal to modulate behavior match environment, may facilitate success novel habitats, such as dispersal islands, biotic invasions, urban adaptation. Cognitive specializations also be associated with specific ecological traits, habitat complexity. Furthermore, our understanding neural brain primarily limited studies relative size. first chapter provides a more depth introduction these topics. this dissertation, I explore neuroanatomy, ecology Anolis lizards. lizards exhibit diversity specializations, result adaptive radiation West Indies. As mentioned above, cognitive mechanisms anoles play role adjusting environments exploiting new niches. second chapter, modified detour task evaluate whether wild, free-living sagrei can solve problem under conditions. compare neuron nonneuron number density cristatellus evermanni see differences neuroanatomy reflect their differential performance on extractive foraging task. how data relate published observations from other vertebrates. Finally, fourth expand upon two previous evaluating follows predictions concerted or mosaic evolution five species Puerto Rican complexity explains species. conclude final summarizing my results outlining future directions. Taken together, presented dissertation demonstrate potential for studying evolutionary context. methods applied used connection fitness lizards, tractable model My third chapters took approach neuroanatomical density, generated insights into Anolis. By ectotherms, begin finally understand

Language: Английский

Toxicogenomic profiling after sublethal exposure to nerve- and muscle-targeting insecticides reveals cardiac and neuronal developmental effects in zebrafish embryos DOI Creative Commons
Hannes Reinwald,

Julia Alvincz,

Gabriela Salinas

et al.

Chemosphere, Journal Year: 2021, Volume and Issue: 291, P. 132746 - 132746

Published: Nov. 5, 2021

For specific primary modes of action (MoA) in environmental non-target organisms, EU legislation restricts the usage active substances pesticides or biocides. Corresponding regulatory hazard assessments are costly, time consuming and require large numbers non-human animal studies. Currently, predictive toxicology development compounds relies on their chemical structure provides little insights into toxicity mechanisms that precede adverse effects. Using zebrafish embryo model, we characterized transcriptomic responses to a range sublethal concentrations six nerve- muscle-targeting insecticides with different MoA (abamectin, carbaryl, chlorpyrifos, fipronil, imidacloprid & methoxychlor). Our aim was identify affected biological processes suitable biomarker candidates for MoA-specific signatures. Abamectin showed most divergent signature among tested insecticides, linked lipid metabolic processes. Differentially expressed genes (DEGs) after exposure were primarily associated immune system inflammation. In total, 222 early responsive either identified, many related three major processes: (1) cardiac muscle cell functioning (tcap, desma, bag3, hspb1, hspb8, flnca, myoz3a, mybpc2b, actc2, tnnt2c), (2) oxygen transport hypoxic stress (alas2, hbbe1.1, hbbe1.3, hbbe2, hbae3, igfbp1a, hif1al) (3) neuronal plasticity (npas4a, egr1, btg2, ier2a, vgf). The thyroidal function gene dio3b upregulated by chlorpyrifos downregulated higher abamectin concentrations. Important (tcap) forebrain (npas4a) frequently ifferentially across all insecticide treatments. We consider identified sets as useful warning candidates, i.e. developmental targeting heart brain aquatic vertebrates. findings provide better understanding about molecular events response analyzed MoA. Perceptively, this promotes sensitive informative biomarker-based vitro assays toxicological prediction AOP refinement, without suffering adult fish.

Language: Английский

Citations

34
Trait sensitivity to stress and cognitive bias processes in fish: A brief overview DOI Creative Commons
Jhon Buenhombre, Erika Alexandra Daza-Cardona, Daniel Mota‐Rojas

et al.

Personality Neuroscience, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Abstract Like other animals, fish have unique personalities that can affect their cognition and responses to environmental stressors. These individual personality differences are often referred as “behavioural syndromes” or “stress coping styles” include traits such boldness, shyness, aggression, exploration, locomotor activity, sociability. For example, bolder proactive may be more likely take risks present lower hypothalamo–pituitary–adrenal/interrenal axis reactivity compared shy reactive individuals. Likewise, learning memory differ between personalities. Reactive individuals tend faster better association recall with aversive stimuli, while bold learn quickly when presented appetitive incentives. However, the influence of on cognitive processes than achievement in has been scarcely explored. Cognitive bias tests employed investigate interplay emotion both humans animals. Fish (CBP) which fish’s interpretation stimuli could influenced by its current emotional state open modulation. no study explored whether CBP, like species, interpreted long-lasting characteristics explain variation. We hold perspective CBP serve a vulnerability factor for onset, persistence, recurrence stress-related disorders. Therefore, studying trait interactions variations valuable future efforts enhance our understanding anxiety stress neurobiology animal models humans.

Language: Английский

Citations

3
Embryonic exposure to fentanyl induces behavioral changes and neurotoxicity in zebrafish larvae DOI Creative Commons

Binjie Wang,

Jiale Chen, Sheng Zhong

et al.

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e14524 - e14524

Published: Dec. 15, 2022

The use of fentanyl during pregnancy, whether by prescription or illicit use, may result in high blood levels that pose an early risk to fetal development. However, little is known regarding the neurotoxicity might arise from excessive exposure growing organisms, particularly drug-related withdrawal symptoms. In this study, zebrafish embryos were exposed solutions (0.1, 1, and 5 mg/L) for days post fertilization (dpf), followed a 5-day recovery period, then larvae evaluated photomotor response, anxiety behavior, shoaling aggression, social preference, sensitization behavior. Fentanyl at 1 mg/L induced elevated anxiety, decreased preference aggressiveness, behavioral larvae. expression genes revealed embryonic caused substantial alterations neural activity ( bdnf , c-fos ) neuronal development plasticity npas4a egr1 btg2 ier2a vgf ). These results suggest neurotoxic, highlighting importance as aquatic species research on neurobehavioral effects opioids vertebrates.

Language: Английский

Citations

8
Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium DOI Creative Commons
Yasuko Isoe, Ryohei Nakamura, Shigenori Nonaka

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 25, 2023

The dorsal telencephalon (i.e. the pallium) exhibits high anatomical diversity across vertebrate classes. non-mammalian pallium accommodates various compartmentalized structures among species. developmental, functional, and evolutional of remain unillustrated. Here, we analyzed structure epigenetic landscapes cell lineages in medaka fish ( Oryzias latipes ) that possesses a clearly delineated (Dd2). We found pallial regions, including Dd2, are formed by mutually exclusive clonal units, each compartment distinct landscape. In particular, Dd2 unique open chromatin pattern preferentially targets synaptic genes. Indeed, shows density synapses. Finally, identified several transcription factors as candidate regulators. Taken together, suggest basic components for functional regionalization compartments their changes have been driving force evolutionary diversity.

Language: Английский

Citations

4
Zebrafish (Danio rerio) behavioral phenotypes not underscored by different gut microbiota DOI Creative Commons
Paul A. Ayayee, Ryan Y. Wong

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 31, 2024

Abstract Different animal behavioral phenotypes maintained and selectively bred over multiple generations may be underscored by dissimilar gut microbial community compositions or not have any significant dissimilarity in composition. Operating within the microbiota-gut-brain axis framework, we anticipated differences microbiome profiles between zebrafish ( Danio rerio ) to display bold shy personality types. This would highlight microbe-mediated effects on host behavior. To this end, amplified sequenced a fragment of 16S rRNA gene from guts individuals (n=10) via Miseq. We uncovered no difference within-group diversity nor between-group composition two phenotypes. Interestingly, though statistically different, determined that phenotype was dominated Burkholderiaceae, Micropepsaceae, Propionibacteriaceae . In contrast, Beijerinckaceae, Pirelullacaeae, Rhizobiales_Incertis_Sedis , Rubinishaeraceae. The absence microbiota suggest species, there might exist stable “core” microbiome, regardless phenotypes, possibly, limited role for modulating selected-for is first study characterize distinct innate (that are considered dysbiotic states) rely antibiotic probiotic treatments induce changes Such studies crucial our understanding impacts normative

Language: Английский

Citations

1
Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1 DOI
Yitian Wu, Ziyuan Lin, Feng Chen

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124792 - 124792

Published: Aug. 23, 2024

Language: Английский

Citations

1
Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish DOI
Wenjun Shi,

Xiao-Bing Long,

Siying Li

et al.

Aquatic Toxicology, Journal Year: 2022, Volume and Issue: 248, P. 106177 - 106177

Published: April 21, 2022

Language: Английский

Citations

4
Mate Choice, Sex Roles and Sexual Cognition: Neuronal Prerequisites Supporting Cognitive Mate Choice DOI Creative Commons
Theodora Fuss

Frontiers in Ecology and Evolution, Journal Year: 2021, Volume and Issue: 9

Published: Nov. 11, 2021

Across taxa, mate choice is a highly selective process involving both intra- and intersexual selection processes aiming to pass on one’s genes, making pivotal tool of sexual selection. Individuals adapt behavior dynamically in response environmental social changes. These changes are perceived sensorily integrated neuronal level, which ultimately leads an adequate behavioral response. Along with perception prior appropriate response, the choosing sex has (1) recognize discriminate between prospective mates (2) be able assess compare their performance order make informed decision. To do so, cognitive allow for simultaneous processing multiple information from (in-) animate environment as well variety (but non-sexual) conspecific cues. Although many aspects cognition one side displays other understood, interplay mechanisms governing determinants, i.e., have been described only vaguely. This review aimed throw spotlight prerequisites, networks supporting interaction choice, roles cognition, hence, choice. How does activity differ males females regarding cognition? Does or respective role within prevailing mating system mirror at level? competence affect choice? Conversely, how abilities sexes? Benefitting studies using different neuroanatomical techniques such markers, differential coexpression candidate gene analyses, modulatory effects neurotransmitters hormones, imaging fMRI, there ample evidence pointing reflection least individual brain regions. Moreover, this aims summarize influencing vice versa. At same time, new questions arise centering complex relationship neurobiology, we will perhaps answer experimental techniques.

Language: Английский

Citations

2
Sub-chronic administration of fluoxetine does not alter prey-capture or predator avoidance behaviors in adult South African clawed frogs (Xenopus laevis). DOI Creative Commons

Nikhil Menon,

Caoyuanhui Wang,

James A. Carr

et al.

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 442, P. 114317 - 114317

Published: Jan. 25, 2023

Language: Английский

Citations

0
Sub-Chronic Administration of Fluoxetine Does Not Alter Prey-Capture or Predator Avoidance Behaviors in Adult South African Clawed Frogs (Xenopus laevis) DOI
James A. Carr,

Nikhil Menon

SSRN Electronic Journal, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 1, 2022

Animals will halt foraging efforts and engage defensive behaviors in response to predator cues. Some researchers have proposed that the switch from appetitive avoidance behavior resembles anxiety, but most work on this has been performed a limited number of animal models, primarily zebrafish rodents. We used adult South African clawed frogs ( Xenopus laevis ) determine if canonical anxiolytic fluoxetine alters predator-induced changes laboratory-based trade-off task mimics foraging/predator tradeoffs wild. hypothesized sub-chronic treatment (20 d) would not affect baseline reverse food intake, behavior, abundance anxiety related gene transcripts optic tectum, brain area central ecological decision making frogs. found significantly reduced locomotion compared vehicle-treated animals. Fluoxetine had no effect were sensitive cues assay did alter any anxiety-related tectum. conclude while peripheral administration reduces locomotion, it does modify approach assay. Are findings are consistent with visual causing state

Language: Английский

Citations

0