Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 11, 2023

Abstract The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, scientific community has improved cell‐based drug assays models. Those advances result more informative biochemical development 3D multicellular models to describe biological complexity better enhance simulation vivo microenvironment. Despite overall dominance conventional macroscopic methods, they present physicochemical operational challenges that impair scale‐up by not allowing a high parallelization, multidrug combination, high‐throughput screening. Their combination complementarity with microfluidic platforms enable microfluidics‐based unequivocal advantages therapies. Thus, this review presents an updated consolidated view miniaturization's physical, chemical, considerations scenario. It clarifies field using gradient‐based microfluidics, droplet‐based printed‐based digital‐based SlipChip, paper‐based microfluidics. Finally, it comparative analysis performance methods life achieve increased precision process.

Language: Английский

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Novel method in emerging environmental contaminants detection: Fiber optic sensors based on microfluidic chips

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159563 - 159563

Published: Oct. 18, 2022

Language: Английский

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Recent Progress on Microfluidics Integrated with Fiber-Optic Sensors for On-Site Detection

Sensors, Journal Year: 2024, Volume and Issue: 24(7), P. 2067 - 2067

Published: March 24, 2024

This review introduces a micro-integrated device of microfluidics and fiber-optic sensors for on-site detection, which can detect certain or several specific components their amounts in different samples within relatively short time. Fiber-optics with micron core diameters be easily coated functionalized, thus allowing to integrated separate, enrich, measure micro-device. Compared traditional laboratory equipment, this exhibits natural advantages size, speed, cost, portability, operability, making it more suitable detection. In review, the various optical detection methods used are introduced, including Raman, ultraviolet–visible, fluorescence, surface plasmon resonance detections. It also provides detailed overview applications biological analysis, food safety, environmental monitoring. Lastly, addresses prospects future development sensors.

Language: Английский

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Microfluidic-based technologies for diagnosis, prevention, and treatment of COVID-19: recent advances and future directions

Biomedical Microdevices, Journal Year: 2023, Volume and Issue: 25(2)

Published: March 13, 2023

Language: Английский

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Advances in Simple, Rapid, and Contamination-Free Instantaneous Nucleic Acid Devices for Pathogen Detection

Biosensors, Journal Year: 2023, Volume and Issue: 13(7), P. 732 - 732

Published: July 14, 2023

Pathogenic pathogens invade the human body through various pathways, causing damage to host cells, tissues, and their functions, ultimately leading development of diseases posing a threat health. The rapid accurate detection pathogenic in humans is crucial pressing. Nucleic acid offers advantages such as higher sensitivity, accuracy, specificity compared antibody antigen methods. However, conventional nucleic testing time-consuming, labor-intensive, requires sophisticated equipment specialized medical personnel. Therefore, this review focuses on advanced systems that aim address issues time, portability, degree automation, cross-contamination. These include extraction-free testing, fully automated extraction, amplification, detection, well enclosed commercial equipment. Additionally, biochemical methods used for are briefly described. We hope will inspire further research more suitable reagents devices rapid, point-of-care diagnostics.

Language: Английский

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Emerging Bioanalytical Devices and Platforms for Rapid Detection of Pathogens in Environmental Samples

Micromachines, Journal Year: 2022, Volume and Issue: 13(7), P. 1083 - 1083

Published: July 8, 2022

The development of robust bioanalytical devices and biosensors for infectious pathogens is progressing well with the advent new materials, concepts, technology. progress also stepping towards developing high throughput screening technologies that can quickly identify, differentiate, determine concentration harmful pathogens, facilitating decision-making process their elimination therapeutic interventions in large-scale operations. Recently, much effort has been focused on upgrading these analytical to an intelligent technological platform by integrating them modern communication systems, such as internet things (IoT) machine learning (ML), expand application horizon. This review outlines recent applications detect pathogenic microbes environmental samples. First, nature outbreaks foodborne, waterborne, airborne microbial toxins are discussed understand severity problems. Next, discussion focuses detection systems chronologically, starting conventional methods, advanced techniques, emerging technologies, other portable platforms pathogens. Finally, multiplex assays, wearable devices, integration smartphone facilitate pathogen wider highlighted.

Language: Английский

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Femtosecond Laser Nanomachining of High‐Aspect‐Ratio Channels in Bulk Fused Silica

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: 9(18)

Published: May 16, 2024

Abstract Thee‐dimensional nano‐structuring of bulk fused silica glass remains a challenging issue due to limitations traditional fabrication methods. In the present work hollow mm‐length channels is demonstrated in by femtosecond laser irradiation followed chemical etching, achieving feature sizes 300 nm. The tight focusing and threshold energy conditions allow reveal unexplored regimes. robustness repeatability process are through diffraction gratings, made parallel with variable pitches even sub‐wavelength regime.

Language: Английский

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Recent advances in microfluidics and environmental analysis

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 329 - 344

Published: Jan. 1, 2025

Language: Английский

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Rapid Fluorescent Probe Detection of Magnesium Impurities in High-Purity Lithium Carbonate Brine Systems

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 776 - 776

Published: Feb. 7, 2025

The magnesium impurities in lithium carbonate cannot be detected quickly an aqueous environment. To solve this bottleneck problem, study proposes a new method for the rapid detection of trace Mg2+ using water-soluble fluorescent probe. A probe was obtained by introducing hydroxyl groups on oxazole ring. After modification, hydrogen bonding between and water molecules increased more than 62 times. Consequently, energy loss outward transfer increased, resulting weak fluorescence saline systems. captured N ring O phenolic group through 1:1 coordination ratio within structure. attraction complex 16 Additionally, orbital gap reduced from 2.817 to 0.383 eV. Meanwhile, impeded phototropic electron effect process, enhanced completing process 3 10 s, with limit 6.06 μmol/L. This can promote real-time quality control refining purification carbonate, as well effectively reduce production costs.

Language: Английский

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Automating interferometric focal length measurement techniques with varifocal optics

Optics Communications, Journal Year: 2025, Volume and Issue: unknown, P. 131703 - 131703

Published: March 1, 2025

Language: Английский

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