Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(09), P. 14750 - 14757
Published: Jan. 1, 2023
Language: Английский
Animals, Journal Year: 2023, Volume and Issue: 13(7), P. 1223 - 1223
Published: March 31, 2023
Animal research is considered a key element in advance of biomedical science. Although its use controversial and raises ethical challenges, the contribution animal models medicine essential for understanding physiopathology novel treatment alternatives several human diseases. Current pandemics’ pathology, such as 2019 Coronavirus disease, has been studied primate, rodent, porcine to recognize infection routes develop therapeutic protocols. Worldwide issues diabetes, obesity, neurological disorders, pain, rehabilitation medicine, surgical techniques require studying process different species before testing them on humans. Due their relevance, this article aims discuss importance diverse lines by analyzing contributions various utilized science over past five years about topics concerning health.
Language: Английский
Citations
109
Molecular Pain, Journal Year: 2023, Volume and Issue: 19
Published: June 1, 2023
Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended treatment 77 diseases. And 16 these diseases are related inflammatory pain. As combination and modern electrotherapy, electroacupuncture (EA) satisfactory analgesic effects on various acute chronic Because its good no side effects, widely accepted all over world. Despite increase number studies, mechanisms via which exerts have not conclusively established. A literature review research great significance elaborate inform further directions. We elucidated action pain from two levels: peripheral central. It includes periphery (immune cells neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor endogenous opioid peptide system) central nervous system (TPRV1, glutamate receptors, glial cells, GABAergic interneurons signaling molecules). In this review, we collected relevant recent studies systematically explain treating pain, with view providing direction future applications promoting clinical development.
Language: Английский
Citations
17
Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(5), P. 2949 - 2963
Published: Nov. 13, 2023
As one of the commonly used therapies for pain-related diseases in clinical practice, electroacupuncture (EA) has been proven to be effective. In chronic pain, neurons anterior cingulate cortex (ACC) have reported hyperactive, while mechanism by which cannabinoid type 1 receptors (CB1Rs) ACC are involved EA-mediated analgesic mechanisms remains elucidated. this study, we investigated potential central EA analgesia. A combination techniques was detect expression and function CB1R, including quantitative real-time PCR (q-PCR), western blot (WB), immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), vivo multichannel optical fibre recording, neuronal activity examined two-photon imaging electrophysiological recording. We found that hyperactivity pyramidal during inflammatory pain is associated with impairment endocannabinoid system. at Zusanli acupoint (ST36) can reduce exert effects increasing ligands anandamide (AEA), 2-arachidonoylglycerol (2-AG) CB1R. More importantly, CB1R necessary conditions analgesia effect, may related negative regulation N-methyl-D-aspartate receptor (NMDAR) activation downregulating NR1 subunits NMDAR (NR1) via histidine triad nucleotide-binding protein (HINT1). Our study suggested system plays an important role acupuncture provides evidence a
Language: Английский
Citations
5
Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 9
Published: Nov. 10, 2022
Pain is an intrinsically unpleasant experience with features that protect organism by promoting motivation and learning. relief, a negative reinforcement of pain, considered reward activates the brain’s system. The circuit in brain involves pain. Acupuncture has multidimensional comprehensive regulating effect on chronic However, acupuncture relieving pain mechanism involved analgesia are not thoroughly studied. In this article, we have reviewed definition abnormalities emotions patients conceptual characteristics analgesic reward, new progress studying circuits functions. Moreover, expounded critical clinical scientific significance related circuits, obtained from human neuroimaging studies, survey results effects reward/motivation circuits. Some viewpoints suggestions been put forward to clarify benign regulation analgesia. Studies loop help deepen understanding analgesia, innovate research concept provide for further studies central improving future.
Language: Английский
Citations
8
PubMed, Journal Year: 2024, Volume and Issue: 27(1), P. 66 - 73
Published: Jan. 1, 2024
Chronic pain is considered as lasting for more than three months and has emerged a global health problem affecting individuals society. extensive the main syndrome upsetting with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, depression, Transient receptor potential vanilloid 1 (TRPV1) been reported to transduce inflammatory signals brain.
Language: Английский
Citations
1
The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
The central and peripheral nervous systems are specialized to conduct electrical currents that underlie behaviour. When this multidimensional system is disrupted by degeneration, damage, or disuse, externally applied may act modulate neural structures provide therapeutic benefit. administration of stimulation can exert precise multi-faceted effects at cellular, circuit levels restore enhance the functionality providing an access route target specific cells, fibres passage, neurotransmitter systems, and/or afferent/efferent communication enable positive changes in Here we examine mechanisms thought seen with current neuromodulation technologies. To gain further insights into associated stimulation, summarize recent findings from genetic dissection studies conducted animal models. KEY POINTS: Electricity everywhere around us essential for how our nerves communicate within bodies. damaged not working properly, using exogenous electricity help improve their function distinct - inside individual circuits, across entire systems. This method be tailored types nerve fibres, neurotransmitters pathways, offering significant potential. overview explains affects its potential benefits, based on research studies. Understanding these important because plays a key role medical treatments neurological conditions.
Language: Английский
Citations
1
ACS Chemical Neuroscience, Journal Year: 2022, Volume and Issue: 13(23), P. 3362 - 3377
Published: Nov. 11, 2022
Kinesin superfamily proteins transport a diverse range of cargo, including excitatory receptors to the dendrite and axon neuron via retrograde anterograde fashions along microtubules, causing central sensitization neuropathic pain. In this study, we have performed in silico molecular dynamics simulation delineate dynamic interaction betaine with KIF17, kinesin protein, known be involved The results from study suggest that betaine-KIF17 complex is stabilized through hydrogen bonding, polar interactions, water bridges. Findings vivo studies significant increase pain hypersensitivity, oxido-nitrosative stress, KIF17 overexpression sciatic nerve, dorsal root ganglion (DRG), spinal cord nerve-injured rats, which was significantly attenuated on treatment betaine. Betaine also restored increased NR2B expressions levels proinflammatory cytokines neuropeptides DRG rats. current attenuates rats by inhibiting KIF17-NR2B-mediated neuroinflammatory signaling.
Language: Английский
Citations
5
World Journal of Acupuncture - Moxibustion, Journal Year: 2022, Volume and Issue: 33(1), P. 3 - 5
Published: Nov. 30, 2022
Language: Английский
Citations
5
Journal of Integrative Neuroscience, Journal Year: 2023, Volume and Issue: 22(4)
Published: July 17, 2023
Chronic pain refers to that persists for over three months. may restrict activities of daily living, including work, learning, social life, and can lead anxiety, depression, sleep disturbance. Imaging data have demonstrated central sensitization often occurs in the brain patients with chronic pain, which arises from imbalanced neurotransmission nervous system. Transient receptor potential vanilloid 1 (TRPV1) is an ion channel serve as inflammatory detector brain. We aim determine properties acupoint catgut embedding (ACE) on cold stress-induced mice fibromyalgia (FM) surveyed character TRPV1 linked molecules FM pain.Intermittent stress (ICS) was used induce model. Mice were subgrouped into normal mice, ICS-induced group, ACE, Trpv1-/- group. ACE a novel acupuncture technique provides convenience continuous nerve stimulation has been reported effective management.Our behavioral experiments showed similar levels response among all groups before treatment. After ICS, prolonged mechanical thermal initiated (mechanical threshold: 1.96 ± 0.12 g; latency: 4.86 0.21 s) alleviated by treatment gene deletion. Inflammatory mediators increased plasma while related kinases amplified hypothalamus cerebellum. These changes ameliorated ACE-treated groups.These findings suggest be modulated or The analgesic effect through pathway reflect its therapeutic target
Language: Английский
Citations
2
Neuroscience, Journal Year: 2023, Volume and Issue: 536, P. 104 - 118
Published: Nov. 15, 2023
Language: Английский
Citations
2