Postępy Higieny i Medycyny Doświadczalnej,
Journal Year:
2023,
Volume and Issue:
77(1), P. 59 - 64
Published: Jan. 1, 2023
Abstract
Introduction
There
is
evidence
of
the
existence
quantitative
changes
in
microbiome,
including
Bifidobacterium
spp.,
due
to
some
chronic
diseases,
such
as
liver
cirrhosis,
inflammatory
bowel
obesity,
or
celiac
disease.
Materials
and
Methods
We
aimed
examine
number
total
bacteria
present
colon
patients
with
type
1
diabetes
(T1DM)
2
(T2DM),
well
healthy
subjects.
DNA
was
extracted
from
patients’
fecal
samples
then
amplified
by
real-time
PCR
determine
bacteria.
Statistical
association
selected
clinical
biochemical
features
examined.
Results
The
mean
numbers
belonging
genus
T1DM
T2DM
were
lower
compared
control
group
(p
=
0.006,
p
<
0.001
respectively).
no
statistical
differences
between
all
groups
0.397).
In
group,
a
significant
correlation
detected
bifidobacteria
age
(r
0.441,
0.010),
alanine
aminotransferease
0.022,
r
−0.11).
T2DM,
observed
triglycerydes
0.001,
−0.61).
Moreover,
we
have
found
negative
HBA1,
glucose
level,
−0.35,
−0.024,
0.019,
Conclusions
composition
controls.
Further
studies
are
needed
clarify
relationship
these
elements
picture
T1DM.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2728 - 2728
Published: June 13, 2023
The
very-low-calorie
KD
(VLCKD)
is
characterized
by
a
caloric
intake
of
under
800
kcal/day
divided
into
less
than
50
g/day
carbohydrate
(13%)
and
1
to
1.5
g
protein/kg
body
weight
(44%)
43%
fat.
This
low
changes
the
energy
source
from
glucose
ketone
bodies.
Moreover,
clinical
trials
have
consistently
shown
beneficial
effect
VLCKD
in
several
diseases,
such
as
heart
failure,
schizophrenia,
multiple
sclerosis,
Parkinson’s,
obesity,
among
others.
gut
microbiota
has
been
associated
with
metabolic
conditions
person
regulated
diet
interactions;
furthermore,
it
that
role
homeostasis
regulating
metabolism,
appetite,
energy.
Currently,
there
increasing
evidence
an
association
between
dysbiosis
pathophysiology
obesity.
In
addition,
molecular
pathways,
metabolites,
how
modulation
could
be
remain
unclear,
more
research
needed.
objective
present
article
contribute
overview
impact
on
intestinal
composition
individuals
obesity
through
literature
review
describing
latest
regarding
topic
highlighting
which
bacteria
phyla
are
VLCKD.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(11), P. 6068 - 6081
Published: Jan. 1, 2024
Epigallocatechin
gallate
(EGCG),
a
prominent
bioactive
compound
found
in
tea,
offers
numerous
health
benefits.
Previous
studies
have
highlighted
its
potential
mitigating
hyperuricemia.
In
this
study,
hyperuricemic
mice
induced
by
potassium
oxonate
(PO)
were
treated
with
EGCG
or
the
anti-hyperuricemia
medication
allopurinol
(AP)
to
investigate
mechanisms
underlying
their
anti-hyperuricemic
effects.
The
results
demonstrated
that
both
and
AP
significantly
reduced
serum
uric
acid
(UA)
levels.
Further
analysis
revealed
promoted
expression
of
UA
secretion
transporter
genes
(
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 28, 2024
Gut
microecology,the
complex
community
consisting
of
microorganisms
and
their
microenvironments
in
the
gastrointestinal
tract,
plays
a
vital
role
maintaining
overall
health
regulating
various
physiological
pathological
processes.
Recent
studies
have
highlighted
significant
impact
gut
microecology
on
regulation
uric
acid
metabolism.
Natural
products,
including
monomers,
extracts,
traditional
Chinese
medicine
formulations
derived
from
natural
sources
such
as
plants,
animals,
microorganisms,
also
been
investigated
for
potential
modulating
According
to
research,
The
stability
is
crucial
link
products
maintain
healthy
metabolism
reduce
hyperuricemia-related
diseases.
Herein,
we
review
recent
advanced
evidence
revealing
bidirectional
between
And
separately
summarize
key
extracts
herbal
both
aspects.
In
addition,we
elucidated
important
mechanisms
secondary
diseases
through
microecology,
especially
by
composition
microbiota,
mucosal
barrier,
inflammatory
response,
purine
catalyzation,
associated
transporters.
This
may
offer
novel
insight
into
its
disorders
management
highlight
perspective
exploring
therapeutic
drugs
products.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 12, 2023
Currently,
hyperuricemia
has
shown
a
surprisingly
rising
trend,
which
attracts
widespread
attention
due
to
potentially
major
health
risks.
Considering
the
inevitable
side
effects
of
long-term
medicine,
probiotics
are
emerging
as
potential
therapeutics
their
ability
improve
uric
acid
metabolism
and
superior
safety.In
our
study,
two
strains
probiotics,
Lactobacillus
gasseri
LG08
(LG08)
Leuconostoc
mesenteroides
LM58
(LM58)
isolated
from
kimchi
were
evaluated
for
prebiotic
properties
in
vitro
uric-lowering
vivo.
Here,
animal
model
16S
rRNA
gene
amplicons
analysis
further
studied
investigate
whether
these
exert
different
prevention
treatment.In
vivo
indicators
intestinal
flora
immunity
revealed
that
both
significantly
prevent
development
progression
hyperuricemia,
repair
antioxidant
system
maintain
balance
healthy
rats,
especially
LM58.
After
was
formed,
although
effect
could
decrease
level
acid,
reverse
levels
body
limited.In
findings
have
important
implications
therapy,
provided
more
mechanistic
insights
into
hyperuricemia.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 10871 - 10871
Published: Oct. 10, 2024
Probiotics,
known
for
regulating
gut
microbiota,
may
aid
those
with
overweight
or
obesity,
but
their
mechanisms
require
more
research.
This
study
involved
75
obese
young
adults,
randomly
assigned
to
either
a
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e20328 - e20328
Published: Sept. 1, 2023
ObjectThis
study
aims
to
investigate
the
changes
in
gut
microbiota
and
metabolism
of
patients
with
chronic
kidney
disease
(CKD)
stage
1–2,
as
well
potential
impact
hyperuricemia
(HUA)
on
these
factors
CKD
1–2
patients.MethodsIn
this
study,
fecal
samples
were
collected
from
without
HUA
(CKD-N
group),
(CKD-H
healthy
people
controls
(HCs
group).
The
then
subjected
microbiome
(16S
rRNA
gene
sequencing)
metabolome
(liquid
chromatography-tandem
mass
spectrometry)
analyses.
multi-omics
datasets
analyzed
individually
integrated
for
combined
analysis
using
various
bioinformatics
approaches.ResultsGut
microbial
dysbiosis
was
found
CKD-N
CKD-H
patients.
At
phylum
level,
compared
HCs
group,
Bacteroidetes
decreased
but
Proteobacteria
increased
group
significantly.
Fusobacteria
significantly
lower
than
group.
genus
[Eubacterium]_ventriosum_group,
Fusobacterium,
Agathobacter,
Parabacteroides,
Roseburia
changed
groups.
[Ruminococcus]_gnavus_group
Moreover,
altered
d-glutamine
d-glutamate
metabolism,
arginine
proline
histidine
lysine
biosynthesis
down-regulated
Phenylalanine
purine
beta-alanine
up-regulated
There
a
significant
difference
between
two
groups
phenylalanine
metabolism.
abundance
change
[Ruminococcus]_gnavus_group,
UCG-002,
Alistipes,
Bifidobacterium
had
close
correlation
differential
metabolites.ConclusionThe
metabolic
status
undergo
people.
Additionally,
has
been
patients,
their
association
metabolites
suggests
that
former
plays
crucial
role
Frontiers in Pediatrics,
Journal Year:
2023,
Volume and Issue:
11
Published: March 20, 2023
Despite
affecting
up
to
20%
of
infants
in
the
United
States,
there
is
no
cure
for
atopic
dermatitis
(AD),
also
known
as
eczema.
Atopy
usually
manifests
during
first
six
months
an
infant's
life
and
one
predictor
later
allergic
health
problems.
A
diet
human
milk
may
offer
protection
against
developing
dermatitis.
One
component,
oligosaccharides
(HMOs),
plays
important
role
a
prebiotic
establishing
infant
gut
microbiome
has
immunomodulatory
effects
on
immune
system.
The
purpose
this
review
summarize
available
information
about
bacterial
members
intestinal
microbiota
capable
metabolizing
HMOs,
genes
or
metabolic
products
present
tract
early
life,
relationship
these
development
AD/eczema
infants.
We
find
that
specific
HMO
metabolism
gene
sets
metabolites
produced
by
bacteria
enable
protective
atopy
because
interactions
with
identify
areas
additional
research
further
elucidate
between
atopy.
Detailed
metagenomic
studies
its
associated
metabolomes
are
essential
characterizing
potential
impact
milk-feeding