Persistent SARS-CoV-2 Infection, EBV, HHV-6 and Other Factors May Contribute to Inflammation and Autoimmunity in Long COVID

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 400 - 400

Published: Jan. 31, 2023

A novel syndrome called long-haul COVID or long is increasingly recognized in a significant percentage of individuals within few months after infection with SARS-CoV-2. This disorder characterized by wide range persisting, returning even new but related symptoms that involve different tissues and organs, including respiratory, cardiac, vascular, gastrointestinal, musculo-skeletal, neurological, endocrine systemic. Some overlapping symptomatologies exist between myalgic encephalomyelitis/chronic fatigue (ME/CFS). Very much like ME/CFS, infections herpes family viruses, immune dysregulation, the persistence inflammation have been reported as most common pattern for development COVID. review describes several factors determinants proposed, elaborating mainly on viral persistence, reactivation latent viruses such Epstein–Barr virus human herpesvirus 6 which are also associated pathology superantigen activation system, disturbance gut microbiome, multiple tissue damage autoimmunity. Based these factors, we propose diagnostic strategies measurement IgG IgM antibodies against SARS-CoV-2, EBV, HHV-6, superantigens, microbiota, biomarkers autoimmunity to better understand manage this multi-factorial continues affect millions people world.

Language: Английский

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The Impact of Physical Activity and Inactivity on Cardiovascular Risk across Women’s Lifespan: An Updated Review

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(13), P. 4347 - 4347

Published: June 28, 2023

Physical inactivity (PI) represents a significant, modifiable risk factor that is more frequent and severe in the female population worldwide for all age groups. The physical activity (PA) gender gap begins early life leads to considerable short-term long-term adverse effects on health outcomes, especially cardiovascular (CV) health. Our review aims highlight prevalence mechanisms of PI across women’s lifespan, describing beneficial PA many physiological pathological clinical scenarios underlining need awareness global commitment promote strategies bridge limit current future generations.

Language: Английский

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A systematic analysis of the literature on the post-COVID-19 condition in Latin America focusing on epidemiology, clinical characteristics, and risk of bias

Medwave, Journal Year: 2025, Volume and Issue: 25(01), P. e3014 - e3014

Published: Jan. 16, 2025

This analysis article aimed to identify and analyze all articles published on the post-COVID-19 condition in Latin America Caribbean, focusing epidemiology, clinical characteristics, risk of bias. We did a systematic survey literature with broad inclusion criteria. The only exclusion criteria were referring post-acute COVID-19 sequelae after an intensive care unit stay, which we distinguish from condition. searched MEDLINE/PubMed, LILACS, SciELO, Scopus, Web Science, Epistemonikos. included 55 records, 48 original (44 observational research, 29 had comparison group; four reviews). Various definitions for long COVID reported, or none, few used World Health Organization None studies reported prevalence rates region. extracted signs symptoms our Using Johanna Briggs Institute critical appraisal tools analytic found that most prone limitations biases. conclude more research should be done using rigorous study designs inform public health strategies.

Language: Английский

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Prevalence and factors associated with long COVID in adults from Southern Brazil: findings from the PAMPA cohort

Cadernos de Saúde Pública, Journal Year: 2023, Volume and Issue: 39(12)

Published: Jan. 1, 2023

Most COVID-19 survivors have reported experiencing persistent symptoms after the infection - these types of cases are known as long COVID. Since Brazil was an epicenter pandemic, a high burden COVID is expected. This study aimed to identify prevalence and factors associated with in adults Southern Brazil, analyzing data from PAMPA cohort. Participants filled out self-reported online questionnaire June 2022. only included subjects who tested positive for COVID-19. Long defined by any that persisted at least three months SARS-CoV-2 infection. Poisson's regression models robust variance were used COVID; results ratios (PR) respective 95% confidence intervals (95%CI). A total 1,001 participants (77.4% women, mean age [SD] = 38.3 [11.9] years) analyzed. The among patients 77.4% (95%CI: 74.7; 79.9). likelihood higher unvaccinated (PR 1.23, 95%CI: 1.06; 1.42), those chronic conditions 1.13, 1.04; 1.24), hospitalized due 1.24, 1.16; 1.32). also women 1.21, 1.09; 1.33) than men. Physical activity reduced fatigue, neurological complications, coughing, headaches It found four experienced Public policies aiming reduce must be prioritized, especially groups risk developing this harmful condition.

Language: Английский

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Prevalence of depression, anxiety, stress, and suicide tendency among individual with long-COVID and determinants: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0312351 - e0312351

Published: Jan. 28, 2025

Background While mental health alterations during active COVID-19 infection have been documented, the prevalence of long-term consequences remains unclear. This study aimed to determine symptoms—depression, anxiety, stress, and suicidal tendencies—and identify their trends associated risk factors in individuals with long-COVID. Methods We conducted a systematic literature search databases including PubMed, EMBASE, Scopus, CINAHL, Cochrane Library, Web Science, PsycINFO up August 2024, targeting observational studies published English. Study quality was assessed using structured standard tools. The primary outcome pooled depression, tendencies Secondary outcomes included these problems over time identification determinants. Results A total 94 eligible were analysis. estimates, regardless follow times duration, as follows: 25% (95%CI:22–28%; PI:1–59%); anxiety (adjusted via trim fill method), 23%(95%CI:21–25%;PI:2–35%); composite depression and/or (95%CI:23–27%;PI:2–51%); 26%(95%CI:13–39%;PI:1–69%); suicidality, 19%(95%CI:15–22%;PI:13–25%). results meta-regression analyses revealed statistically significant trend showing gradual decrease (RD = -0.004,P 0.022). Meta-regression indicated that being female younger age significantly higher symptoms. design setting did not contribute heterogeneity. Conclusion One-fourth individual long-COVID experience symptoms, which remain prevalent even two years post-infection despite slight decreasing trend. Factors such gender linked rates depression. These findings indicate need for ongoing screening early interventions mitigate psychological distress patients.

Language: Английский

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Exploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort

American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Understanding how lifestyle factors impact psychiatric well-being is essential for supporting recovery in COVID-19 survivors, yet their influence on long-term outcomes remains underexplored. This cross-sectional study evaluates associations between depression, generalized anxiety disorder (GAD), post-traumatic stress (PTSD), suicidal ideation (SI), and syndromic common mental (CMD) with 730 moderate to severe survivors. Lifestyle included physical activity, alcohol substance use during infection, dietary intake, assessments conducted 6 11 months post-hospitalization. Multiple logistic regression was employed each of the five dependent variables. Of participants, 51.9% were male, a mean age 55. Previous sedative severity correlated increased depression (sedative, OR = 2.43, P .011; 1.09, .017), GAD 2.13, .007; 1.08, .009), PTSD 2.10, .008; .004), CMD (OR 1.97, .005). Opioid linked 2.23, .042), "fruits vegetables" consumption 2-3 times/week associated lower odds 0.19, .021). No behaviors found be ideation. These results underscore importance lifestyle-specific mitigating symptoms extended period from COVID-19. particularly pertinent respect minimizing sedatives context GAD, PTSD, as well opioids intake fruits vegetables depression. findings may have substantial implications formulation strategies aimed at prevention health disorders subsequent acute viral infections.

Language: Английский

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Muscle Radiodensity Reduction in COVID-19 Survivors Is Independent of NLR Levels During Acute Infection Phase

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 521 - 521

Published: March 28, 2025

COVID-19 survivors often experience late symptoms, possibly secondary to an exacerbated inflammatory response. This study aimed investigate whether levels, assessed by the neutrophil-to-lymphocyte ratio (NLR) during hospitalization in acute phase of SARS-CoV-2 infection, affect skeletal muscle phenotype and adipose tissue outpatient follow-up after discharge. retrospective, single-center included hospitalized from March 2020 April 2021, who attended follow-ups 3 9 months Patients were divided into two groups based on levels hospitalization: (1) low NLR (≤4.2) (2) high (>4.2). The using computed tomography. 60 patients: 20 40 NLR. group was unexpectedly younger, but had longer hospital stays required more intensive care. We observed a reduction radiodensity increase fat both groups. However, we no differences subcutaneous visceral between follow-up. conclude that show reduced increased infiltration post-hospitalization, regardless infection. In addition, age intramuscular are associated with reducing radiodensity. highlights need for targeted rehabilitation address long-term effects recovery.

Language: Английский

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Exploring the landscape of long COVID: prevalence and associated factors in patients assisted by a telehealth service

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 11, 2025

Long COVID is a condition that occurs in patients with previous history of COVID-19, and symptoms cannot be explained by another diagnosis persist. To evaluate the prevalence long associated factors treated public telehealth service during acute COVID-19. This was cross-sectional study involving users COVID-19 offered critical phase pandemic, called TeleCOVID-MG. Individuals older than 18 years age who tested positive for SARS-CoV-2 were monitored social isolation eligible. Prevalence calculated, descriptive analysis group comparisons (patients without symptoms) performed addition to logistic regression odds ratios 95% confidence intervals. Among 699 included study, 60.8% women aged between 30 49 (44.6%) had high school education (46.5%). The main comorbidities hypertension (20.9%), diabetes (8.3%), heart disease (3.9%). incidence 26.8% (95% CI: 23.5; 30.1). Cognitive (49.7%), chronic diarrhea (49.2%), cough (40.6%) most persistent symptoms. Female sex (OR: 2.51), secondary 2.13), elementary 2.81), monthly income 600 1,000 USD 5.85), supplementary health assistance 1.98), anosmia 4.52) need in-person care 2.44) higher COVID. affected almost one-third population. Although pandemic under control, virus continues infect individuals, raising doubts about long-term complications disease.

Language: Английский

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Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 14, 2024

Introduction Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both persistent and post-acute disease newly acquired symptoms are not yet fully described. Given lack robust knowledge regarding mechanisms PCC we have examined impact inflammation in PCC, evaluating serum cytokine profile its potential involvement inducing different Methods In this cross-sectional study, recruited 227 participants who were hospitalised acute COVID-19 2020 came back for follow-up assessment 6–12 months after hospital discharge. enrolled two symptomatic groups: Self-Reported Symptoms group (SR, n = 96), did present major organ lesions, reported several debilitating such fatigue, muscle weakness, loss sense smell taste; decreased Pulmonary Function (SRPF, 54), composed individuals same described SR, plus diagnosed pulmonary lesions. A Control ( 77), minor complaints following COVID-19, was also included study. Serum levels, symptom questionnaires, physical performance tests general clinical data obtained assessment. Results SRPF presented lower IL-4 concentration compared q 0.0018) SR 0.030), IFN-α2 content 0.007). addition, higher MIP-1β 0.029). CCL11 0.012 0.001, respectively) MCP-1 levels 0.052 both) SRPF. G-CSF to 0.014). Female showed handgrip strength relation 0.0082). Male needed more time complete timed up-and-go test, men 0.0302 0.0078, respectively). Our results indicate profiles accompanied distinct inflammatory markers circulation. Of particular concern function findings, likely long-lasting consequences health quality life, found phenotypes.

Language: Английский

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Proteomics of serum-derived extracellular vesicles are associated with the severity and different clinical profiles of patients with COVID-19: An exploratory secondary analysis

Cytotherapy, Journal Year: 2024, Volume and Issue: 26(5), P. 444 - 455

Published: Feb. 15, 2024

Language: Английский

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