Association between Surrogate Markers of Insulin Resistance and the Incidence of Colorectal Cancer in Korea: A Nationwide Population-Based Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1628 - 1628

Published: March 12, 2024

Background: Insulin resistance (IR) is assessed using surrogate markers such as the triglyceride–glucose (TyG) index, triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for IR (METS-IR). Limited studies investigated their association with colorectal cancer (CRC) incidence, no research has been conducted on METS-IR. Method: This study used claims data from Korean National Health Insurance Service, analyzing a cohort of 314,141 Koreans aged over 40 who participated in Screening Program 2009 to 2010. The follow-up period was extended until 31 December 2019. Participants were divided into four groups based quartiles (Q1–Q4) markers. Results: All had sequentially statistically lower disease-free probabilities Q1 Q4. Cox proportional hazard model demonstrated significant positive associations between CRC incidence Q3 Q4 TyG well TG/HDL-C ratio constrained cubic spline method revealed nonlinear, dose–response relationship index METS-IR relation incidence. Conclusions: In conclusion, positively correlated Koreans.

Language: Английский

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Inhibition of Pancreatic Lipase by Flavonoid Derivatives: In Vitro and In Silico Investigations

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 10

Published: Jan. 24, 2024

Obesity, characterized by excessive adipose tissue accumulation, has emerged as a crucial determinant for wide range of chronic medical conditions. The identification effective interventions obesity is utmost importance. Widely researched antiobesity agents focus on pancreatic lipase, significant therapeutic target. This study presented the evaluation ten flavonoid compounds in terms their inhibitory activities against utilizing both vitro and silico approaches. results indicated that all tested demonstrated modest weaker compared to reference compound, orlistat. Among investigated, F01 exhibited highest potency, with an IC50 value 17.68 ± 1.43 µM. enzymatic inhibition kinetic analysis revealed operated through competitive mechanism determined $K_i$ 7.16 μM. suggested moderate binding affinity lipase enzyme. Furthermore, associated id="M2">Vmax was quantified at 0.03272 ΔA·min−1. In studies displayed mode similar orlistat, despite lacking active functional group capable forming covalent bond Ser152 catalytic triad. However, formed hydrogen this amino acid. interacted other residues enzyme’s site, particularly those within lid domain. Based these findings, demonstrates substantial potential candidate further investigations.

Language: Английский

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The association between neighborhood socioeconomic status and the risk of incidence and mortality of colorectal cancer: A systematic review and meta-analysis of 1,678,582 participants

Cancer Epidemiology, Journal Year: 2024, Volume and Issue: 91, P. 102598 - 102598

Published: June 15, 2024

Language: Английский

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Glucagon-like peptide-1 receptor agonists significantly affect the quality of bowel preparation for colonoscopy

Endoscopy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) affect gastrointestinal motility, slowing gastric emptying and colonic transit. GLP-1RAs have an impact on residue before endoscopy, but only limited data are available regarding its effect the adequacy of preparation. We investigated association between GLP-1RA use inadequate bowel preparation (IBP) for colonoscopy.

Language: Английский

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Influence of BMI on robotic rectal cancer surgery: a systematic review and meta-analysis

Journal of Robotic Surgery, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 3, 2025

Language: Английский

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The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity

Obesity Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Colorectal cancer (CRC) is the third most common worldwide and has one of highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation development, obesity at forefront. Obesity regarded as key environmental determinants for pathogenesis CRC. Excessive food intake a sedentary lifestyle, together genetic predispositions, lead to overgrowth adipose tissue along disruption in number function building cells. Adipose tissue-resident cells may constitute part microenvironment. Alterations their physiology secretory profiles observed further contribute progression, despite similar localization, contributions not equivalent. They can interact cells, either directly or indirectly, influencing various processes that tumorigenesis. The main aim this review provide insights into diversity resident namely, adipocytes, stromal immunological regarding role particular cell types co-forming scope study was also devoted abnormalities states impact on development.

Language: Английский

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Evaluation of the Antioxidant and Anti-Cancer Potential of Microwave-Assisted Opuntia humifusa (Korean Cheonnyencho) Aqueous Extract

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 88 - 88

Published: Jan. 31, 2025

O. humifusa (Korean Cheonnyencho), a prickly pear cactus species, has garnered increased attention owing to its rich phytochemical composition and potential health benefits. In this study, the antioxidant anti-cancer activities of microwave-assisted aqueous extract derived from were investigated, content was characterized. High-performance liquid chromatography (HPLC) used identify various bioactive compounds, including polyphenols, flavonoids, other antioxidants known for their health-promoting properties. Furthermore, individual compounds in flavonoids separated using HPLC fractionation technique. The evaluated 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. results demonstrated significant activity extract, as evidenced by ability scavenge free radicals effectively reduce oxidized molecules. experiments involved treating colon cancer cells with varying concentrations (25 125 mg/mL) over 24-h period, resulting remarkable dose-dependent inhibition cell growth. Notably, inhibitory effect absent HDFa cells, highlighting selectivity targeting cells.

Language: Английский

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System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice

Animal Models and Experimental Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

It is increasingly recognized that young, chow-fed inbred mice poorly model the complexity of human carcinogenesis. In humans, age and adiposity are major risk factors for malignancies, but most genetically engineered mouse models (GEMM) induce carcinogenesis too rapidly to study these influences. Standard strains, such as C57BL/6, commonly used in GEMMs, further limit exploration aging metabolic health effects. A similar challenge arises modeling periodontitis, a disease influenced by aging, diabesity, genetic architecture. We propose using diverse populations with hybrid vigor, Collaborative Cross (CC) × ApcMin hybrid, slow progression better colorectal cancer (CRC) comorbidities. This perspective highlights advantages this model, where delayed reveals interactions adiposity. Unlike mice, which develop rapidly, CC hybrids recapitulate human-like progression. facilitates identification modifier loci affecting inflammation, diet susceptibility, organ size, polyposis distribution. The offers transformative platform studying CRC adulthood, reflecting its complex interplay insights gained from approach will enhance early detection, management, treatment strategies related conditions.

Language: Английский

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Special Diets and Nutrient Intakes in Morbidly Obese US Adults in Comparison to the 2020–2025 Dietary Guidelines for Americans

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

Morbid Obesity (MO), defined by a Body Mass Index (BMI) > 40 kg/m2, is the most severe form of obesity. The risk suffering from any chronic medical condition almost twice as high in MO compared to overweight. Despite obesity being one serious contemporary public health concerns, there paucity nutrient intake data adults with MO. Nutritional assessments morbidly obese are often based on individuals seeking weight loss surgery rather than focusing general community. Using National Health and Nutrition Examination Surveys (NHANES, 2007-2016), we estimated intakes US population MO, thereby comparative assessment Dietary Guidelines for Americans (DGA, 2020-2025). Nutrient were assessed BMI regardless their intention seek treatment reporting special diets. Sex- age-specific performed, aim identify subgroups that may warrant particular attention perspective. study sample comprised 1,708 participants This be extrapolated represent 14,047,276 Americans. was more prevalent females males (65.60% vs 34.40%) sample's average age 46.25 years, tendency towards lower mean higher groups. alignment DGA poor across both sexes, particularly regard nutrients concern (fiber, calcium), saturated fatty acid several fat-soluble vitamins. Fiber found low Total energy not associated Morbidly frequently reported diets, up 28% examined disclosing at least diet. descriptive epidemiological approach, identified numerous sociodemographic nutritional factors national dietary guidelines warrants considerations dedicated nutrition efforts combat increasing obesity-related burden.

Language: Английский

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Exploring the Influence of Age, Gender and Body Mass Index on Colorectal Cancer Location

Medicina, Journal Year: 2023, Volume and Issue: 59(8), P. 1399 - 1399

Published: July 30, 2023

Background and objectives: The global burden of non-communicable diseases like obesity cancer, particularly colorectal cancer (CRC), is increasing. present study aimed to investigate the association between CRC location (proximal vs. distal) patient demographic factors including age, sex, BMI, as well stage at diagnosis. Materials Methods: In this cross-sectional study, data from 830 patients diagnosed with were analyzed. variables included weight, height, location, Patients stratified into three age groups BMI categories, we analyzed these using Chi-squared tests multivariate logistic regression. Results: rectum ascending colon most common locations malignant neoplasms. No statistically significant differences in across observed. Significant found groups, normal weight overweight categories. Normal obese had a higher proportion Stage 3 4 cancers. Obesity emerged predictor for rectal regression analysis, an odds ratio 1.56. However, no associations other gender, or stage. Conclusions: Our revealed that cancers, emerging cancer. It important note while was be development likely influenced by various beyond those studied here. Therefore, further research needed roles potential risk factors, loss SIRT6 adipose tissue homeostasis. Additionally, inflammation associated microbiota mucosa, systemic gene expression, visceral may also play progression Understanding intricate relationships crucial better screening, disease prognosis, management strategies.

Language: Английский

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