Anti-lipase Activity of Kemuning (Murraya paniculata) Leaves Extract and Its Fractions DOI Creative Commons

Nuri Nuri,

Tazkiyatul Fitriyah,

Endah Puspitasari

et al.

Journal of Agromedicine and Medical Sciences, Journal Year: 2024, Volume and Issue: 10(1), P. 53 - 53

Published: March 1, 2024

Kemuning (Murraya paniculata) belongs to the Rutaceae family, it grows a lot in tropical areas such as Indonesia. Traditionally, leaves are used for weight loss preparations and believed contain compounds that can inhibit pancreatic lipase, including flavonoids. This study aimed reveal antilipase activity of extract its fractions. The extraction was carried out by maceration with 70% ethanol solvent. vacuum liquid chromatography method separate secondary metabolites stationary phase silica gel eluent mixture n-hexane, ethyl acetate, methanol gradient manner. Meanwhile, tested colorimetric method, p-nitrophenyl butyrate substrate orlistat positive control. obtained 19.94% simplicia. separated collected 20 flasks then combined based on Rf value spots observed thin layer (TLC) producing 8 fractions (fractions A-H). percentage yields A-H were 1.20, 1.33, 1.80, 3.92, 3.57, 4.20, 16.85, 14.47%, respectively. Antilipase indicated IC50 values, which 17.603 ± 1.660 108.554 µg/mL extract, activities 130.19 2.90, 119.52 1.95, 96.95 1.81, 91.65 0.78, 95.30 1.46, 114.76 2.87, 127.07 3.56, 134,04 3.16 µg/mL, Based these results, be concluded exhibit very strong activity. Keywords: Murraya paniculata; extract; fraction;

Language: Английский

Isolation and identification of novel hemp seed protein-derived pancreatic lipase inhibitory peptides DOI

Zhenghai Zhang,

Jingyi Ge,

Li W

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 63, P. 105834 - 105834

Published: Jan. 1, 2025

Language: Английский

Citations

3
Morin inhibits the activity of pancreatic lipase and adipogenesis DOI

V P Venkateish,

Sundarraj Rajamanikandan,

Madan Kumar Perumal

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 977, P. 176705 - 176705

Published: June 1, 2024

Language: Английский

Citations

7
Characterization and Evaluation of MFG-E8 Protein-Derived Peptides: From Isolation to Functional Assessment in Skeletal Muscle Lipid Metabolism DOI
He Li,

Kaifang Guan,

Yangming Gao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104395 - 104395

Published: May 23, 2024

Language: Английский

Citations

1
Purple and red rice (Oryza sativa L.) bran polyphenols show antiobesity and antidiabetic activities DOI Creative Commons
Stephen M. Boué, William Broussard,

Abigail Michelz

et al.

Cereal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Background and Objectives Rice bran is a source of bioactive polyphenols. This study aimed to characterize the antidiabetic potential different rice brans (one brown, two red, purple) by examining their ability inhibit α‐amylase, α‐glucosidase, pancreatic lipase, stimulate glucose uptake in adipocytes. Findings All pigmented extracts significantly inhibited α‐glucosidase. Both red α‐amylase close 50% at highest dose tested. four lipase vitro (IC 50 values 4.38–10.09 mg/mL). The studied contained higher levels total polyphenolic content (TPC), flavonoid (TFC), antioxidant capacity when compared brown bran. Purple anthocyanins proanthocyanidins. consisted benzoic acids, while had cinnamic acids. Tricin was identified all brans. Conclusions Our indicates that have manage obesity diabetes due inhibitory effects on lipid carbohydrate digestion. Several polyphenols were identified. Significance Novelty confirmed.

Language: Английский

Citations

0
Anti-lipase Activity of Kemuning (Murraya paniculata) Leaves Extract and Its Fractions DOI Creative Commons

Nuri Nuri,

Tazkiyatul Fitriyah,

Endah Puspitasari

et al.

Journal of Agromedicine and Medical Sciences, Journal Year: 2024, Volume and Issue: 10(1), P. 53 - 53

Published: March 1, 2024

Kemuning (Murraya paniculata) belongs to the Rutaceae family, it grows a lot in tropical areas such as Indonesia. Traditionally, leaves are used for weight loss preparations and believed contain compounds that can inhibit pancreatic lipase, including flavonoids. This study aimed reveal antilipase activity of extract its fractions. The extraction was carried out by maceration with 70% ethanol solvent. vacuum liquid chromatography method separate secondary metabolites stationary phase silica gel eluent mixture n-hexane, ethyl acetate, methanol gradient manner. Meanwhile, tested colorimetric method, p-nitrophenyl butyrate substrate orlistat positive control. obtained 19.94% simplicia. separated collected 20 flasks then combined based on Rf value spots observed thin layer (TLC) producing 8 fractions (fractions A-H). percentage yields A-H were 1.20, 1.33, 1.80, 3.92, 3.57, 4.20, 16.85, 14.47%, respectively. Antilipase indicated IC50 values, which 17.603 ± 1.660 108.554 µg/mL extract, activities 130.19 2.90, 119.52 1.95, 96.95 1.81, 91.65 0.78, 95.30 1.46, 114.76 2.87, 127.07 3.56, 134,04 3.16 µg/mL, Based these results, be concluded exhibit very strong activity. Keywords: Murraya paniculata; extract; fraction;

Language: Английский

Citations

0