SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: A Cohort Study of Pregnant People in a Maternity Hospital in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Early in the COVID-19 pandemic, there was no evidence that posed greater risk to pregnant people. Over subsequent year, it became clear pregnancy rendered more at higher of severe COVID-19. There is, however, a paucity data regarding perinatal outcomes low-middle income countries (LMIC). The aim this study evaluate effect SARS-CoV-2 infection on adverse maternal and reference maternity hospital, low setting Rio de Janeiro during pandemic. Methods conducted prospective cohort 1,185 people ≥ 16 years admitted hospital their infants from March 2020 2022. Participants with laboratory confirmed SARS CoV-2 were considered infected. An exploratory analysis qualitative variables absolute relative frequencies 95% confidence intervals calculated. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time outcomes, adjusted for vaccination, comorbidity gestational trimester. Results A total 21% (249/1185) patients infected SARS-CoV-2, median age 26 (range: 16–47). Cesarean section deliveries performed 54% (135/249) + participants vs 41.7% (391/936) uninfected, p = < 0.001. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm occurred frequently testing positive (30.7% 23.6). In survival analysis, prematurity (HR: 0.85, CI: 0.66–1.11) including fetal distress 0.94, 0.59–1.49); stillbirth 0.84, IC: 0.42–1.71) neonatal death 0.91, 0.39–2.14), even after adjusting trimester infection. Intensive care unit admission and/or 68 1185 (5.7%); 44 249 (17.7%) vs. 24 936 uninfected (2.5%). Patients (crude HR: 6.12, 3.70-10.14; 5.60, 3.35–9.37) than participants. All 21 who died unvaccinated against Conclusion due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 207 - 207

Published: Jan. 31, 2025

Understanding perinatal health outcomes following SARS-CoV-2 infection during pregnancy necessitates large-scale studies of mother-infant dyads. Hospital-based pregnant women and their neonates provide valuable insights within the field research. The aim this study was to evaluate effect on maternal among hospitalized in Rio de Janeiro COVID-19 pandemic. consisted a time-to-event analysis hospital-based cohort 1185 ≥ 16 years infants from May 2020 March 2022. Pregnant were classified as infected if they had SARS CoV-2 positive RT-PCR or rapid antigen test. An exploratory qualitative variables conducted with calculation absolute relative frequencies 95% confidence intervals. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time adverse outcomes, adjusted for vaccination, comorbidity, gestational trimester. A total 21% (249/1185) SARS-CoV-2, median age 26 (range: 16-47). Cesarean section deliveries performed 57% (135/237) CoV-2+ participants vs. 43% (391/914) uninfected participants, p < 0.001. Intensive care unit admission and/or death occurred 68 (5.7%), 44 249 (17.7%) 24 936 (2.5%). All 21 who died unvaccinated against COVID-19. Women at greater risk (crude HR: 5.93, CI: 3.58-9.84; 5.47, 3.16-9.48) than women. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm more frequently patients testing (30.7% 23.6). In survival analysis, no prematurity (HR: 0.92, 0.68-1.23) including fetal distress 1.29, 0.82-2.05), stillbirth 1.07, 0.48-2.38), neonatal 0.96, 0.35-2.67), even after adjusting trimester, periods time. due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

Citations

0
Child COVID-19 vaccine uptake among participants of the 2015 Pelotas (Brazil) Birth Cohort Study DOI
Ana Lúcia Sartori, Romina Buffarini,

Aline Machado da Silva

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(24), P. 126105 - 126105

Published: July 11, 2024

Language: Английский

Citations

2
Time series analysis of comprehensive maternal deaths in Brazil during the COVID-19 pandemic DOI Creative Commons
Mary Catherine Cambou, H. Benjamin Fredrick David, Corrina Moucheraud

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 14, 2024

The effects of the COVID-19 pandemic on comprehensive maternal deaths in Brazil have not been fully explored. Using publicly available data from Brazilian Mortality Information (SIM) and System Live Births (SINASC) databases, we used two complementary forecasting models to predict estimates mortality ratios using (MMR) (MMRc) years 2020 2021 based 2008 2019. We calculated national regional standardized ratio for (SMR) (SMRc) 2021. observed MMRc was more than double predicted Holt-Winters autoregressive integrated moving average (127.12 versus 60.89 59.12 per 100,000 live births, respectively). found persisting sub-national variation mortality: SMRc ranged 1.74 (95% confidence interval [CI] 1.64, 1.86) Northeast 2.70 CI 2.45, 2.96) South were highest past three decades. Increased resources prenatal care, health, postpartum care may be needed reverse trend deaths.

Language: Английский

Citations

1
Acceptance and hesitancy of COVID-19 vaccination among Saudi pregnant women DOI Creative Commons

Sereen Hawsawi,

Abeer Orabi,

Hend Alnajjar

et al.

Frontiers in Global Women s Health, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 26, 2024

Introduction Since the COVID-19 pandemic started, it has significantly impacted health systems and societies worldwide. Pregnancy increases risk of severe illness when associated with COVID-19. Pregnant women are likely to experience COVID-19-related pregnancy complications however many them were hesitant receive vaccine. This study aimed assess acceptance hesitancy vaccination among pregnant in Jeddah. Methods The present utilized a descriptive cross-sectional research design include through convenience sampling at obstetrics gynecology outpatient department antenatal ward King Abdul-Aziz Medical City, Data was collected from August October 2022 using structured questionnaire. Results Approximately one-third 264 participants (36.4%) strongly disagreed that they had developed immunity against More than half (61% 66.3% respectively) heard vaccine unsafe for their babies during pregnancy, would contain virus. However, 50% agreed ease precautionary measures. A high score toward observed working sector. most frequently reported reason refusal belief mother her baby pregnancy. Discussion Most perceived susceptibility infection as low take because worry about its effectiveness. indicated willingness if mandatory received adequate information it. These findings correspond previous studies conducted Saudi Arabia explore reluctance breastfeeding vaccination.

Language: Английский

Citations

0
A Retrospective Cross-Sectional Analysis of Viral SARI in Pregnant Women in Southern Brazil DOI Creative Commons

Sonia Maria Lissa,

Bruna Amaral Lapinski,

Maria Graf

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1555 - 1555

Published: July 30, 2024

Pregnant women (PW) are at a higher risk of diseases and hospitalization from viral respiratory infections, particularly influenza SARS-CoV-2, due to cardiopulmonary immunological changes. This study assessed the impact infections on PW hospitalized with severe acute infection (SARI) prior COVID-19 pandemic. It is cross-sectional 42 85 non-pregnant (NPW) admitted SARI two tertiary hospitals between January 2015 December 2019. The rates virus prevalence, hospitalization, length hospital stay, oxygen supplementation, intensive care unit (ICU) admission, death were comparable NPW. A multivariate analysis showed that had rate hospitalizations (OR = 2.37; 95% CI 1.02-5.48) as compared NPW, being most prevalent (aOR 7.58; 1.53-37.66). stays 0.83; 0.73-0.95) admissions ICU 0.028; 0.004-0.25) lower in greater frequency group PW, these better outcome than NPW earlier antiviral treatment they received.

Language: Английский

Citations

0
SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: A Cohort Study of Pregnant People in a Maternity Hospital in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Early in the COVID-19 pandemic, there was no evidence that posed greater risk to pregnant people. Over subsequent year, it became clear pregnancy rendered more at higher of severe COVID-19. There is, however, a paucity data regarding perinatal outcomes low-middle income countries (LMIC). The aim this study evaluate effect SARS-CoV-2 infection on adverse maternal and reference maternity hospital, low setting Rio de Janeiro during pandemic. Methods conducted prospective cohort 1,185 people ≥ 16 years admitted hospital their infants from March 2020 2022. Participants with laboratory confirmed SARS CoV-2 were considered infected. An exploratory analysis qualitative variables absolute relative frequencies 95% confidence intervals calculated. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time outcomes, adjusted for vaccination, comorbidity gestational trimester. Results A total 21% (249/1185) patients infected SARS-CoV-2, median age 26 (range: 16–47). Cesarean section deliveries performed 54% (135/249) + participants vs 41.7% (391/936) uninfected, p = < 0.001. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm occurred frequently testing positive (30.7% 23.6). In survival analysis, prematurity (HR: 0.85, CI: 0.66–1.11) including fetal distress 0.94, 0.59–1.49); stillbirth 0.84, IC: 0.42–1.71) neonatal death 0.91, 0.39–2.14), even after adjusting trimester infection. Intensive care unit admission and/or 68 1185 (5.7%); 44 249 (17.7%) vs. 24 936 uninfected (2.5%). Patients (crude HR: 6.12, 3.70-10.14; 5.60, 3.35–9.37) than participants. All 21 who died unvaccinated against Conclusion due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

Citations

0