Epidemiology and pathogenesis of osteoarthritis DOI Creative Commons
Seung Woo Han

Journal of Korean Medical Association, Journal Year: 2024, Volume and Issue: 67(10), P. 620 - 628

Published: Oct. 10, 2024

Background: Osteoarthritis (OA) is the most common form of arthritis and poses a considerable socioeconomic burden, contributing to disability decreased quality life, particularly in older adults. However, current treatment for OA limited pain relief, it necessary develop disease-modifying drugs that target specific molecular mechanisms its pathogenesis.Current Concepts: The prevalence increases with age, incidence being higher individuals aged over 60 years. Furthermore, women are more likely knee hand OA, whereas hip men. global burden increasing, driven by an aging population increasing obesity. main pathological feature degradation cartilage extracellular matrix catabolic proteases such as metalloproteinase 13 (MMP13) disintegrin thrombospondin motifs 5 (Adamts5), which regulated various signaling pathways transcription factors. metabolic shift towards glycolysis, associated mitochondrial dysfunction, oxidative stress, ultimately leading chondrocyte senescence apoptosis. Chondrocytes superficial zone have stem cell-like properties secrete anabolic proteins lubricin fibulin-3. Subchondral bone remodeling emerged critical progression.Discussion Conclusion: understanding has markedly evolved recent years, shifting from traditional view “wear tear” disease multifaceted condition complex pathogenesis. This paradigm could contribute development novel strategies halt progression.

Language: Английский

National prevalence and trends in food labeling awareness, comprehension, usage, and COVID-19 pandemic-related factors in South Korea, 2014–2022 DOI Creative Commons
Yujin Choi, Hyeon Jin Kim, Jaeyu Park

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 31, 2024

Although food labeling on packages is crucial for promoting a healthy diet, limited research has been conducted how the COVID-19 pandemic (hereinafter "the pandemic") affected awareness. Therefore, this study aims to analyze changes in trends awareness, comprehension, and usage South Korea during pandemic. We utilized nationwide, large-scale, long-term dataset provided by Community Health Survey (KCHS) from 2014 2022 (total = 1,756,847 participants). This allowed researchers assess prevalence of usage. Furthermore, we investigated factors associated with awareness specifically related In total, adults (54.19% women) participated study. The upward slope overall became less pronounced even exhibited downward (βdiff - 1.759; 95% CI 1.874 1.644). comprehension more (comprehension: βdiff 0.535; 0.436-0.634; usage: 0.693; 0.601-0.785). vulnerability lower included older age, male, obesity, residing rural areas, household income, educational level, smoking, increased alcohol consumption. analyzed 9-year trend based nationally representative data 2022. Our findings suggest that personalized nutrition strategies are needed recognize vulnerable groups risk improve among Korean

Language: Английский

Citations

10
National trends of allergic diseases and pandemic–related factors among individuals with obesity in South Korea: A nationwide representative serial study, 2005–2021 DOI Creative Commons

Yejun Son,

Jaeyu Park, Yujin Choi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29921 - e29921

Published: April 22, 2024

Although obesity is known to be related allergic diseases, few studies have investigated the prevalence of diseases in individuals with obesity, especially during COVID-19 pandemic. Thus, this study aimed analyze national trends among and sociodemographic factors.

Language: Английский

Citations

6
Global burden of vaccine‐associated rheumatic diseases and their related vaccines, 1967–2023: A comprehensive analysis of the international pharmacovigilance database DOI
Jiyeon Oh,

Hyesu Jo,

Jaeyu Park

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(8)

Published: Aug. 1, 2024

Vaccine-associated rheumatic diseases are rare but one of the most feared adverse drug reactions (ADRs). However, this topic has been investigated less with large-scale data in literature. With rapid progress development and approval vaccines during pandemic, public concerns regarding their safety have raised. To assess global regional burden, long-term trends, potential risk factors vaccines-associated six types (ankylosing spondylitis [AS], polymyalgia rheumatica [PMR], rheumatoid arthritis [RA], Sjögren's syndrome, Systemic lupus erythematosus [SLE], scleroderma), study conducted disproportionality analysis based on reports from World Health Organization International Pharmacovigilance Database documented between 1967 2023 (n for total = 131 255 418) across 156 countries territories. We estimated reporting odds ratio (ROR) information component (IC) to determine signal diseases. Of 198 046 all-cause diseases, 14 703 vaccine-associated were identified. While counts gradually increased over time globally, we observed a dramatic increase after 2020, potentially due large portion COVID-19 mRNA The was pronounced HBV (ROR, 4.11; IC

Language: Английский

Citations

2
Sex-Specific Trends in the Prevalence of Osteoarthritis and Rheumatoid Arthritis From 2005 to 2021 in South Korea: Nationwide Cross-Sectional Study DOI Creative Commons
Seoyoung Park, Yejun Son, Hyeri Lee

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e57359 - e57359

Published: Nov. 1, 2024

Osteoarthritis and rheumatoid arthritis (RA) are prevalent chronic joint disorders, with prevalence rates varying by sex. However, few studies have comprehensively documented the factors contributing to sex-specific of osteoarthritis RA, including sociological impact COVID-19 pandemic.

Language: Английский

Citations

2
National prevalence of atopic dermatitis in Korean adolescents from 2009 to 2022 DOI Creative Commons

Mafaz Kattih,

Hojae Lee,

Hyesu Jo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 29, 2024

Abstract Previous studies have examined the prevalence of allergic diseases in adolescents 1–2 years after emergence COVID-19 pandemic. However, more data is needed to understand long-term impact on diseases. Thus, we aimed examine trend atopic dermatitis Korean before and during pandemic across 14 years. Additionally, analyze risk factors (AD) based results. The Disease Control Prevention Agency conducted Korea Youth Risk Behavior Web-based Survey from 2009 2022, which for this study were obtained. Prevalence trends compared subgroups, β difference (β diff ) was calculated. We computed odds ratios changes disease This included a total 917,461 participants 2022. increased 6.79% (95% CI 6.66–6.91) 2009–2011 6.89% 6.72–7.05) 2018–2019, then decreased slightly 5.82% 5.60–6.04) Across years, middle school student status, low parent’s highest education level, household income, non-alcohol consumption, non-smoker smoking no suicidal thoughts, suicide attempts associated with dermatitis, while female sex, rural residence, high BMI, performance, feelings sadness despair small increase. an 18-year, found that pre-pandemic start remained constant throughout could be explained mainly by large scale social political occurred

Language: Английский

Citations

1
Astaxanthin mediated repair of tBHP-Induced cellular injury in chondrocytes DOI Creative Commons
Wen-Wei Liang, Gang Liu,

Weibo Zhou

et al.

Redox Report, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 4, 2024

Objective This study investigates how astaxanthin (AST) counters tert-butyl hydroperoxide (tBHP)-induced cellular damage in C28/I2 chondrocytes, focusing on the circ-HP1BP3/miR-139-5p/SOD1 signaling pathway and its use sustained-release microspheres for osteoarthritis treatment.

Language: Английский

Citations

1
Design of a Self-Measuring Device Based on Bioelectrical Impedance Analysis for Regular Monitoring of Rheumatoid Arthritis DOI Creative Commons
JuYoung Jeong,

Yun Soo Park,

E B Lee

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(8), P. 2526 - 2526

Published: April 15, 2024

Rheumatoid arthritis (RA) is a chronic disease, in which permanent joint deformation largely preventable with the timely introduction of appropriate treatment strategies. However, there no consensus for patients RA to monitor their progress and communicate it rheumatologist till condition progresses remission. In response this unmet need, we proposed design self-measuring device based on bioelectrical impedance analysis (BIA) regular monitoring inflammation levels. Twenty joints both hands were measured trends Three electrodes used measure two each finger. A central electrode was consecutive measurements. suitable form factor vertical placement hand. To ensure stability measurements, an air cushion incorporated into back hand, hand containers designed sides, mobile application designed. We conducted convergence-assessment experiment five pressures validate consistency convergence bioimpedance heuristic evaluation usability around product parallel by six subject matter experts validated design. This study underscores significance considering patients’ disease activity during intervals between hospital visits introduces novel approach self-RA care.

Language: Английский

Citations

0
National Trends in the Prevalence of Self-Perceived Overweight Among Adolescents Between 2005 and 2022: Nationwide Representative Study (Preprint) DOI

Jinyoung Jeong,

S. Lee, Kyeongmin Lee

et al.

Published: Feb. 27, 2024

BACKGROUND Despite several studies on self-evaluation of health and body shape, existing research the risk factors self-perceived overweight is insufficient, especially during COVID-19 pandemic. OBJECTIVE This study aims to identify affecting examine how prevalence has changed before Specifically, we analyzed impact altered lifestyles due this phenomenon. METHODS The data used in were obtained from middle high school students who participated Korean Youth Risk Behavior Web-based Survey (N=1,189,586). survey was a 2-stage stratified cluster sampling representative South adolescents. We grouped results by year estimated slope pandemic using weighted linear regression, as well tendencies according various factors. ratios for overweight. In addition, conducted comparisons different periods their associations with RESULTS much higher than BMI-based among 1,189,586 participants (grade 7-12) 2005 2022 (female participants: n=577,102, 48.51%). From 2019 (prepandemic), increased (β=2.80, 95% CI 2.70-2.90), but 2020 (pandemic) it decreased (β=–0.53, –0.74 –0.33). During pandemic, individuals levels stress or lower household economic status exhibited more substantial decrease rate tended be poor academic performance, status, poorer subjective health, level. CONCLUSIONS Our nationwide study, over 18 years, indicated that period while identifying low performance These findings suggest need policies facilities address serious dieting dissatisfaction resulting developing counseling programs adolescents such status.

Language: Английский

Citations

0
National trends in thyroid disease and COVID-19 pandemic-related factors, 1998-2021: A nationwide representative study in South Korea DOI Creative Commons
Kyeongmin Lee, Jaeyu Park, Myeongcheol Lee

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e39401 - e39401

Published: Oct. 1, 2024

Language: Английский

Citations

0
A comparative retrospective longitudinal study of arthritis risk and cognitive decline in older adults DOI Creative Commons
Jennifer Ivy Kim, Bada Kang

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 21, 2024

Arthritis often results in unmet healthcare needs for older adults with cognitive decline, who may struggle to communicate pain or recall symptoms. However, the risk factors arthritis this group remain underexplored. We addressed gap by identifying and comparing among varying statuses. Data from 334 participants decline 808 normal cognition were analysed using Korean Longitudinal Study of Aging, tracking diagnoses over 12 years Kaplan–Meier curves Cox proportional hazards regression. Results showed 47.6% developed arthritis, compared 30.1% cognition. Key included depressive symptoms (hazard ratio [HR]: 1.87), living alone (HR: 1.66), infrequent social interactions 1.42), greater dependency daily activities 1.41). In group, additional chronic illnesses 1.41) higher body mass index 1.09) significant factors. Understanding these distinct is crucial preventing managing at groups. Moreover, findings can assist developing comprehensive public health strategies integrating mental support improve outcomes decline.

Language: Английский

Citations

0