Epidemiological analysis of the incidence of COVID-19 among the population of the Republic of Cameroon using the quantum Geographic Information System (QGIS) DOI Open Access
Eben Anne Catherine Youmba,

А. А. Кузин,

A. E. Zobov

et al.

Russian Military Medical Academy Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 301 - 310

Published: Nov. 8, 2024

The results of a retrospective epidemiological analysis the incidence COVID-19 in regions Republic Cameroon dynamics from 2020 to 2023 are presented. It was noted that cases were first reported Central Region Cameroon, and then spread remaining 9 administrative country with an average weekly growth rate 38.1 ± 18.6% 2020, 15.3 13.1% 2021, 13.4 12.2% 2022, respectively, however, varied significantly time space. Epidemiological made it possible rank territory by magnitude rate. highest recorded North region (233.1‰), Coastal (204.9‰) Center (173.7‰). Adamawa Far had lowest rates (25.6‰ 22.5‰, respectively). comparative infection factors contributing rapid Comparative mapping space performed for 10 using full version QGIS (quantum GIS) LTR program; help which distribution across over clearly shown. During study period, link between neighboring African countries demonstrated. has been shown national does not always depend on population density areas, but is also associated other risk may affect occurrence cases.

Language: Английский

Longitudinal humoral immunity against SARS-CoV-2 Spike following infection in individuals from Cameroon DOI
Mehdi Benlarbi,

Dell-Dylan Kenfack,

Katrina Dionne

et al.

Virology, Journal Year: 2025, Volume and Issue: 605, P. 110467 - 110467

Published: Feb. 25, 2025

Language: Английский

Citations

1
Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in mice DOI Creative Commons
Shailendra Kumar Verma,

Fernanda Ana‐Sosa‐Batiz,

Julia Timis

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105361 - 105361

Published: Sept. 30, 2024

Language: Английский

Citations

4
Viral dynamics and factors associated with duration of COVID-19 positivity: evidence from the first-three epidemiological waves in Cameroon DOI Creative Commons
Joseph Fokam,

Aurelie Minelle Kengni Ngueko,

Alex Durand Nka

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 5, 2025

Language: Английский

Citations

0
Contribution of genomic surveillance to the detection and monitoring of SARS-CoV-2 variants during the 6 pandemic waves in the Central African Republic from 2020 to 2023 DOI Creative Commons

Clotaire Donatien Rafaï,

Ernest Lango-Yaya,

Marie Roseline Darnicka Belizaire

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Abstract Objective: The COVID-19 pandemic has highlighted the need to strengthen diagnostic and genomic surveillance capacities. Central African Republic was able manage 5 waves of disease during health monitoring integrated as a tool in 2021. aim this study report data from National Laboratory Clinical Biology Public Health describe landscape circulation SARS-CoV-2 variants. Materials methods: This retrospective, descriptive observational over period 3 years (ranging April 2020 November 2023) carried out on population consenting volunteers throughout CAR tested by RT‒PCR nasopharyngeal samples with sufficient information LNBCSP database. Sequencing is largely at INRB KINSHASA May 2023 LNBCSP. Results discussion: Out 97,864 tests out, 9,764 were positive, which corresponds prevalence 9.98%. average age patients 39.97 ± 13.76 years, sex ratio (M/F) 2.12. positivity significantly associated (p=0.001), (p=0.013) clinical manifestations. Ten variants circulated recorded. circulating dominated Omicron (B.1.1.529) Delta (B.1.617.2) especially B.1.620 B.640, marked second wave CAR-T cells. Conclusion: retrospective series provides key for understanding history CAR. Risk factors identified, variant described. Strengthening national capacities would help country adopt better response against pandemic.

Language: Английский

Citations

0
Contribution of genomic surveillance in the detection and monitoring of SARS variants- CoV-2 during the 6 pandemic waves in the Central African Republic from 2020 to 2023 DOI Creative Commons

Clotaire Donatien Rafaï,

Ernest Lango-Yaya,

Marie Roseline Darnicka Belizaire

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

Abstract Objective: The Covid-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. The Central African Republic was able manage 5 waves during health monitoring integrated as a tool in 2021. aim of this study is report data from National Laboratory Clinical Biology Public Health describe landscape circulation SARS-CoV-2 variants. Materials methods: This retrospective, descriptive observational over period 3 years (ranging April 2020 November 2023) carried out on population consenting volunteers, throughout CAR, tested by RT -PCR nasopharyngeal samples with sufficient information LNBCSP databases. Sequencing largely at INRB KINSHASA May 2023 LNBCSP. Results discussion: Out 97,864 RT-PCR tests out, 9,764 came back positive, which corresponds prevalence 9.98%. average age patients 39.97 ± 13.76 sex ratio M/F 2.12. positivity significantly associated (p=0.001), (p=0.013) clinical manifestations. Ten variants circulated recorded. circulating dominated Omicron (B.1.1.529), Delta (B.1.617.2) especially B.1.620 B.640 marked second wave CAR. Conclusion: retrospective series provides key for understanding history Risk factors are identified variant described. Strengthening national capacities would help country adopt better response against pandemic.

Language: Английский

Citations

0
Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021 DOI Open Access

Clotaire Donatien Rafaï,

Marie-Roseline Darnycka Belizaire,

Pierre Somsé

et al.

Journal of Tuberculosis Research, Journal Year: 2024, Volume and Issue: 12(01), P. 1 - 12

Published: Jan. 1, 2024

Objective: COVID-19 surveillance was established as early March 2020 in the Central African Republic (CAR), after WHO statement relating to identification of several cases outside China. However, given non-performing molecular biology technical platform many developing countries sub-Saharan Africa, second wave promised be surprising and formidable. In this context, a mass survey launched Bangui determine prevalence COVID-19. Patients Methods: From 18 April 2, 2021, screening campaign took place tourist places, companies main hospital infrastructures. Nasopharyngeal swab samples were collected from participants with without symptoms Influenza-like illness (ILI) stored VTM tubes. The Ag (COVID-19) RT-PCR tests carried out at LNBCSP. sequencing SARS-CoV-2 positives INRB. Results: We included 1480 whom 33 (2.23%) SARS-COV-2 positive, 24 male 9 female. This sex difference statistically significant (p = 0.012) ratio M/F 1.09. Sampling sites located 1st arrondissement most prolific 0.006) sequenced. addition analysis predefined under study, 17 control sequences provinces generated during same period are added. detected 2 Variants Of Concern (VOC) including predominant B.1.620 (43.86%) followed by B.1.1.7 or Alpha (5.10%). Conclusion: study showed importance availability means diagnosis identified risk factors sampling site. has shown setting up sentinel for all regions country appropriate use anti-COVID-19 vaccine.

Language: Английский

Citations

0
Genomic Profile of SARS-COV-2 Associated with COVID-19 Outbreaks in N’Djamena, Chad DOI Open Access

Mathieu Hota,

Henry Yandai Fissou,

Dezoumbe Koutaya

et al.

Advances in Bioscience and Biotechnology, Journal Year: 2024, Volume and Issue: 15(07), P. 432 - 442

Published: Jan. 1, 2024

Background: SARS-CoV-2 has circulated worldwide with dramatic consequences. In Chad, we have no data reported of variants. The aim this study was to identify the variants that during epidemic from 2020 2021. Methods: This is a cross-sectional, descriptive carried out between and Samples patients suspected COVID-19 were tested in five laboratories N'Djamena. One hundred quality samples positives sequenced Kinshasa using Oxford nanopore technologies minion Protocol Midnight SARS-CoV2. Data processed Excel version 16 software. Results: Of 100 sequenced, 77 (77%) produced sequences, 23 (23%) did not. genomic profiles wild-type Wuhan minor mutations (19A, 19B (A), 20A (B.1, B.2), 20B (AV.1), 20D (B.1.1.1 /C.36), 20C), variant concern Alpha (20I), Delta (21A/J), interest Eta (21D), Omicron (21K) unclassified under surveillance (B.1.640). these variants, maximums detected aged 26 - 35 30.26% 25.26% 36 45. However, 24.67% travelers 75.32% residents, 35.06% those vaccinated against 62.33% non-vaccinates. estimated case-fatality rate 2.44% (107/4374). Conclusion: work provided preliminary on circulating 2020-2021 epidemics Chad.

Language: Английский

Citations

0
Contribution of Genomic Surveillance in the Detection and Monitoring of SARS-CoV-2 Variants during the 6 Pandemic Waves in the Central African Republic from 2020 to 2023 DOI Open Access

Clotaire Donatien Rafaï,

Ernest Lango-Yaya,

Marie Roseline Darnicka Belizaire

et al.

Journal of Tuberculosis Research, Journal Year: 2024, Volume and Issue: 12(03), P. 151 - 164

Published: Jan. 1, 2024

Language: Английский

Citations

0
Risk factors for mortality in hospitalized COVID-19 patients across five waves in Pakistan DOI Creative Commons

Nosheen Nasir,

Salma Tajuddin, Afshan Akhtar

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 30, 2024

This retrospective cohort study aims to describe the clinical characteristics and outcomes assess risk factors for mortality across epidemic waves in hospitalized COVID-19 patients a major tertiary-care center Pakistan. A total of 5368 with COVID-19, between March 2020 April 2022 were included. The median age was 58 years (IQR: 44-69), 41% females, overall 12%. Comparative analysis showed that proportion aged ≥ 60 highest during post-wave 4 period (61.4%) Wave (Delta) (50%) (p < 0.001). Male predominance decreased from 65.2% 2 44.2% 5 (Omicron) Mortality rate lowest at 9.4% wave 21.6% = 0.041). In multivariable mortality, acute respiratory distress syndrome (ARDS) most strongly associated (aOR 22.98, 95% CI 15.28-34.55, p 0.001), followed by need mechanical ventilation 6.81, 5.13-9.05, Other significant included kidney injury 3.05, 2.38-3.91, stroke 2.40, 1.26-4.60, 0.008), pulmonary embolism (OR 2.07, 1.28-3.35, 0.003), 2.45, 1.95-3.09, Enoxaparin use lower odds 0.45, 0.35-0.60, 0.001. Patients 2.22, 1.39-3.56, 0.001) 2.82, 1.37-5.80, 0.005) had higher compared other waves. identifies admitted Delta post-wave, years, renal complications, anticoagulation

Language: Английский

Citations

0
Epidemiological analysis of the incidence of COVID-19 among the population of the Republic of Cameroon using the quantum Geographic Information System (QGIS) DOI Open Access
Eben Anne Catherine Youmba,

А. А. Кузин,

A. E. Zobov

et al.

Russian Military Medical Academy Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 301 - 310

Published: Nov. 8, 2024

The results of a retrospective epidemiological analysis the incidence COVID-19 in regions Republic Cameroon dynamics from 2020 to 2023 are presented. It was noted that cases were first reported Central Region Cameroon, and then spread remaining 9 administrative country with an average weekly growth rate 38.1 ± 18.6% 2020, 15.3 13.1% 2021, 13.4 12.2% 2022, respectively, however, varied significantly time space. Epidemiological made it possible rank territory by magnitude rate. highest recorded North region (233.1‰), Coastal (204.9‰) Center (173.7‰). Adamawa Far had lowest rates (25.6‰ 22.5‰, respectively). comparative infection factors contributing rapid Comparative mapping space performed for 10 using full version QGIS (quantum GIS) LTR program; help which distribution across over clearly shown. During study period, link between neighboring African countries demonstrated. has been shown national does not always depend on population density areas, but is also associated other risk may affect occurrence cases.

Language: Английский

Citations

0