Altered oral microbiota of drug-resistant organism carriers exhibit impaired gram-negative pathogen inhibition DOI
Susan Zelasko,

Mary-Hannah Swaney,

Won Se Suh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

The oral microbiome has been understudied as a reservoir for clinical pathogens, including drug-resistant strains. Understanding how alterations in functioning render this site vulnerable to colonization is essential, multidrug-resistant organisms (MDRO) carriage major risk factor developing serious infections. To advance our knowledge of MDRO and protection against pathogen conferred by native microbiota, we examined microbiomes from individuals colonized MDROs (n=33) non-colonized age-matched controls (n=30). Shotgun metagenomic analyses swabs study participants revealed significant differences microbial communities with depletion

Language: Английский

Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy DOI Creative Commons
Marzie Mahdizade Ari, Konstantin J. Scholz, Fabian Cieplik

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

The viable but non-cultivable (VBNC) state and persister cells, two dormancy phenomena in bacteria, differ various aspects. entry of bacteria into the VBNC as a survival strategy under stressful conditions has gained increasing attention recent years, largely due to higher tolerance cells antibiotics antimicrobials resulting from their low metabolic activity. oral cavity favors biofilm growth dental hard tissues, tooth decay periodontitis. Despite advances detection food industry environment, capability remains poorly documented. Furthermore, recently been observed pathogens, including Porphyromonas gingivalis, which shows potential relevance chronic systemic infections, Enterococcus faecalis, an important taxon endodontic Helicobacter pylori, exhibits transient presence cavity. Further research could create opportunities develop novel therapeutic strategies control pathogens. inability conventional culture-based methods identify reactivation dormant restore susceptibility therapies highlights notable gap anti-VBNC strategies. lack targeted approaches tested for efficacy against underscores need methods. This review discusses state, its importance public health, diagnostic techniques, with special focus on bacteria.

Language: Английский

Citations

1
Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review DOI Creative Commons
Georgy Leonov, Diana Salikhova, А. В. Стародубова

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1732 - 1732

Published: Aug. 22, 2024

Stroke represents a significant global health burden, with substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers promising avenue for advancing our understanding factors that contribute to risk developing strategies mitigate risk. This review highlights correlations between diseases, such as periodontitis caries, onset stroke. Periodontal pathogens within microbiome have been identified contributing factor in exacerbation stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, endothelial dysfunction. alteration may these conditions, emphasizing vital role prevention cardiovascular disease. integration dental medical practices enhancing efforts improving patient outcomes.

Language: Английский

Citations

5
Circulating bacterial DNA in cardiovascular disease DOI Creative Commons
Sarah Appleby, Rachel Purcell

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Cardiovascular disease (CVD) remains a global health burden despite advances in prevention and treatment. Conventional biomarkers, while effective for number of patient groups, fail to provide personalized diagnosis prognosis, necessitating the exploration novel markers. Advancements sequencing technology have unveiled role cell-free DNA (cfDNA) as reservoir genetic information from all cells within body, associations between elevated cfDNA levels CVD risk factors status been reported. Recent attention has turned subset cfDNA, circulating bacterial (cbDNA), derived gut microbiota, potential biomarker. Investigations into microbial translocation gut, particularly phenomenon ‘leaky gut,’ reveal its association with source cbDNA. Here, we review existing literature on cbDNA CVD, highlighting diagnostic prognostic value. Current studies largely carried out small, disparate cohorts, using different sample types range methodologies. While shows biomarker, lack consensus methodologies populations studied calls standardized approaches large cohorts establish reliable Future research should focus identifying pathological relevance, utilizing advanced techniques conclusive findings.

Language: Английский

Citations

0
BacDive in 2025: the core database for prokaryotic strain data DOI Creative Commons
Isabel Schober, Julia Koblitz, J. Sarda Carbasse

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D748 - D756

Published: Oct. 29, 2024

Abstract In 2025, the bacterial diversity database BacDive is leading for strain-level and archaeal information. It has been selected as an ELIXIR Core Data Resource well a Global Biodata Resource. Since its initial release more than ten years ago, (https://bacdive.dsmz.de) grown tremendously in content functionalities, comprehensive resource covering phenotypic of prokaryotes with data on taxonomy, morphology, physiology, cultivation, more. The current (2023.2) contains 2.6 million points 97 334 strains, reflecting increase by 52% since previous publication 2021. This remarkable growth can largely be attributed to integration world-wide largest collection Analytical Profile Index (API) test results, which are now fully integrated into searchable. A novel knowledge graph provides powerful search options through SPARQL endpoint, including possibility federated searches across multiple sources. high-quality provided increasingly being used training artificial intelligence models resulting genome-based predictions high confidence fill gaps database.

Language: Английский

Citations

3
The Relationship Between Periodontitis, Gingivitis, Smoking, Missing Teeth, Endodontic Infections, Aortic Aneurysm, and Coronary Artery Disease: The 10-Year Results of 25 Patients DOI Open Access

Elizabeth Litvinov,

Alexander V. Litvinov

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Background Emerging research suggests a correlation between poor oral health and cardiovascular diseases (CVDs), with inflammation being central mechanism. Periodontitis gingivitis are chronic inflammatory that can lead to systemic issues if untreated. It has been indicated previously endodontic infections missing teeth may contribute elevated risk, smoking exacerbates both periodontal conditions. This study expands upon existing by examining factors together investigating as potentially amplifying factor. Poor inflammation, which is recognized risk factor for atherosclerosis events. aims evaluate these relationships over decade, providing insights into the potential preventive impact of care on health. Materials methods 10-year retrospective examines complex among (including periodontitis, gingivitis, teeth), infections, smoking, conditions, specifically coronary artery disease (CAD) aortic aneurysm. By analyzing data from 25 patients aged 45-75, assess whether indicators correlate increased risks. The study's methodology included comprehensive dental evaluations each patient, baseline collected at inception follow-ups next decade. Oral assessments documented severity recorded presence infections. Cardiovascular were conducted establish incidence progression CAD aneurysm, while lifestyle factors, particularly noted significant contributors. approach allowed an in-depth exploration possible causal pathways linking outcomes. Results demonstrated severe high numbers teeth, significantly associated higher incidences Smoking, expected, acted compounding factor, intensifying outcomes in Interaction terms further highlighted how combined advanced periodontitis notably risk. findings align hypothesis especially smokers. These results indicate serve marker far-reaching effects beyond alone. Conclusion showed strong association disease, hypertension, CVDs. underscores importance maintaining good cessation mitigate advocate multidisciplinary patient care, integrating broader management. Future recommended confirm larger, more diverse cohorts explore underlying mechanisms connecting

Language: Английский

Citations

3
Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus DOI
Firoz Anwar, Fahad A. Al‐Abbasi,

Omar A. Al-Bar

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

Citations

1
Altered oral microbiota of drug-resistant organism carriers exhibit impaired gram-negative pathogen inhibition DOI
Susan Zelasko,

Mary-Hannah Swaney,

Won Se Suh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

The oral microbiome has been understudied as a reservoir for clinical pathogens, including drug-resistant strains. Understanding how alterations in functioning render this site vulnerable to colonization is essential, multidrug-resistant organisms (MDRO) carriage major risk factor developing serious infections. To advance our knowledge of MDRO and protection against pathogen conferred by native microbiota, we examined microbiomes from individuals colonized MDROs (n=33) non-colonized age-matched controls (n=30). Shotgun metagenomic analyses swabs study participants revealed significant differences microbial communities with depletion

Language: Английский

Citations

0