The Emerging Role of Oyster Mushrooms as a Functional Food for Complementary Cancer Therapy

Foods, Journal Year: 2025, Volume and Issue: 14(1), P. 128 - 128

Published: Jan. 4, 2025

The importance of functional food’s role in human nutrition as well the prevention diseases, especially treatment chronic diseases like cancer, is an innovative field research. Based on studies regarding antioxidant potential oyster mushroom extract, it evident that has anticancer properties. current article reviews health benefits edible oyster-mushroom-derived bioactive compounds, and how they specifically activate or regulate immune system by affecting maturation, differentiation, proliferation cells, thereby inhibiting cancer cell metastasis growth. Mushrooms show regulating a single molecule specific signaling pathway having multiple targets same different pathways. In addition, prebiotic effects mushrooms could enhance quality life during after therapy recovering intestinal microbiota. More clinical research needs to be conducted, future should investigate preventive aspects, which aid reducing rate occurrence, positive impact patients prove are food curing dietary supplement for patients.

Language: Английский

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Development and Validation of Microwave-assisted Extraction for Phenolic Compound Profiling in Diverse Oyster Mushrooms (Pleurotus spp.) Sourced from Various Geographical Regions

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101754 - 101754

Published: Feb. 1, 2025

Language: Английский

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Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 741 - 741

Published: Feb. 22, 2025

Mushrooms are known to be a nutritional powerhouse, offering diverse bioactive compounds that promote and enhance health. provide distinguishable taste aroma an essential source of vitamin D2, B complex, hydroxybenzoic acids (HBAs) hydroxycinnamic (HCAs), terpenes, sterols, β-glucans. Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., Lentinula edodes recognized functional foods due their remarkable potential for disease prevention promotion overall health well-being. These have antioxidants, anti-inflammatory, cytoprotective, cholesterol-lowering, antidiabetic, antimicrobial, anticancer properties, well controlling blood pressure, being immunity booster, strengthening bone properties. In addition, they contain non-digestible oligosaccharides (NDOs) ergothioneine, substrate gut microflora. Supplementing our daily meals with those can add value food, providing benefits. Novel edible mushrooms investigated explore substances therapeutic benefit human The scientific community (mycologists) is currently studying the prospects unlocking full advantages mushrooms. This review aims knowledge culturing conditions, potential, value-added products 11 varieties.

Language: Английский

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Chemical characterization, anticancer, antioxidant and anti-obesity activities with molecular docking studies of Pleurotus ostreatus biomass exposed to moist heat

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

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Sequential extraction of antioxidants from Citrus aurantium L. flower and kinetic evaluation of their effect on oil microparticle oxidative stability

Food Chemistry X, Journal Year: 2025, Volume and Issue: unknown, P. 102448 - 102448

Published: April 1, 2025

This study applied supercritical CO2 and ultrasound-assisted ethanol extraction (UAE) to obtain apolar polar antioxidant fractions from Citrus aurantium flowers. HPLC-HRMS revealed distinct phytochemical profiles, with the extract showing higher phenolic content activity. Linseed oil was co-encapsulated these extracts at varying concentrations (1, 2, 5 mg/g of oil) using Particles Gas Saturated Solution (PGSS) technique, oxidative stability assessed isothermal calorimetry. Key kinetic parameters, such as induction time (τ), oxidation rates (R inh , R uni ), efficiency (A.E.), were measured. The demonstrated superior A.E., further confirmed by DPPH stopped-flow assay. Co-encapsulation both produced an additive effect, surpassing synthetic BHT (200 μg/g). highlights flower natural antioxidants, enhancing encapsulated oils, while offering a sustainable method for bioactive compound recovery food applications.

Language: Английский

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Wild edible mushrooms to achieve sustainable development goals: Novel sources for food security, health, and well-being

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104277 - 104277

Published: May 7, 2024

Language: Английский

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In silico evaluation of potential breast cancer receptor antagonists from GC-MS and HPLC identified compounds in Pleurotus ostreatus extracts

RSC Advances, Journal Year: 2024, Volume and Issue: 14(33), P. 23744 - 23771

Published: Jan. 1, 2024

Introduction: Pharmacotherapeutic targets for breast cancer include the estrogen receptor (ER), progesterone (PR), and human epidermal growth factor (EGFR). Inhibitors of these receptors could be interesting therapeutic candidates treatment management (BC). Aim: This study used GC-MS HPLC to identify bioactive compounds in Pleurotus ostreatus (P. ostreatus) extracts applied silico methods potent EGFR, ER, PR inhibitors from as potential drug candidates. Method: were chemicals P. aqueous (PO-A), methanol (PO-M), ethanol (PO-E), chloroform (PO-C), n-hexane (PO-H). The PR, EGFR model optimization molecular docking compounds/control binding pocket simulated using AutoDock Vina PyRx. drug-likeness, pharmacokinetic, pharmacodynamic features prospective leads all anticipated. Result: results indicated existence 29 PO-A, 36 PO-M PO-E, 42 PO-C, 22 PO-H extracts. With only o-tolylamino-acetic acid (4-nitro-benzylidene)-hydrazide (-7.5 kcal mol-1) ethanolic extract bind receptor. on other hand, identified several with higher affinities than control. Ergotaman-3',6',18-trione (-8.1 mol-1), 5,10-diethoxy-2,3,7,8-tetrahydro-1H,6H-dipyrrolo[1,2-a:1',2'-d]pyrazine (-7.8 extract; (-8.4 had better affinity compared (-7.7 mol-1). Likewise, ergotaman-3',6',18-trione (-9.7 phenol, 2,4-bis(1,1-dimethyl ethyl) (-8.2 control, gefitinib (-7.9 regards EGFR. None or outperformed control any proteins. Phenols flavonoids such quercetin, luteolin, rutin, chrysin, apigenin, ellagic acid, naringenin their Conclusion: class phenols lead molecules due ability strongly proteins' receptors. These showed promising drug-like properties; they safe new creating anticancer medicines.

Language: Английский

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Assessment of Bioactive Compounds in Edible Mushrooms for Digestive Disease Management

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 1, 2025

Language: Английский

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Molecular Docking Appraisal of Pleurotus ostreatus Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment

Bioinformatics and Biology Insights, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 1, 2025

Introduction: Breast cancer (BC) is a heterogeneous disease involving network of numerous extracellular signal transduction pathways. The phosphoinositide 3-kinase (PI3K)/serine/threonine kinase (Akt)/mechanistic target rapamycin (mTOR) pathway crucial for understanding the BC development. Phosphoinositide 3-kinase, phosphatase and tensin homolog (PTEN), mTOR, Akt, 3-phosphoinositide-dependent 1 (PDK1), FoxO1, glycogen synthase 3 (GSK-3), mouse double minute 2 (MDM2), H-Ras, proapoptotic B-cell lymphoma (BCL-2) family protein (BAD) proteins are key drivers this potential therapeutic targets. Pleurotus ostreatus an edible mushroom that rich in flavonoids phenols can serve as inhibitors PI3K/Akt/mTOR pathway. Aim: This study evaluated anticancer properties P through structure-based virtual screening 22 biologically active compounds present mushroom. Method: Model optimization was carried out on PI3K, PTEN, PDK1, GSK-3, MDM2, BAD molecular docking compounds/control binding pocket were simulated AutoDock Vina PyRx. drug likeness, pharmacokinetic, pharmacodynamic features prospective leads all anticipated. Result: Several potent selected driver identified from ostreatus. Ellagic acid with affinities −8.0, −8.1, −8.2, −6.2, −7.1 kcal/mol BAD, respectively, had better affinity compared their reference drugs. Likewise, apigenin (−7.8 kcal/mol), chrysin quercetin (−6.4 chlorogenic (−6.2 kcal/mol) to H-Ras proteins, respectively. Conclusion: acid, apigenin, luteolin, quercetin, chrysin, naringenin phytochemicals seen lead molecules due ability strongly bind under Analogs these also be designed

Language: Английский

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Extract optimization and biological activities of Otidea onotica using Artificial Neural Network-Genetic Algorithm and response surface methodology techniques

BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

In this study, the biological activities of Otidea onotica were investigated using two optimization methods, Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA). The extracts tested for phenolic content, antioxidant potential, acetylcholinesterase butyrylcholinesterase inhibitory antiproliferative effects against A549 lung cancer cell line. results show that obtained by ANN-GA exhibited higher activity compared to RSM had total status (TAS), DPPH FRAP values. Phenolic content analysis revealed eight compounds with highest concentrations caffeic acid (in extract) gallic extract), respectively. Both showed strong cytotoxic cells depending on concentration, extract showing activity. Our study provides important findings therapeutic potential O. particularly reveals method plays an role in increasing can be used treatment neurodegenerative diseases future techniques offer effective strategy enriching contents.

Language: Английский

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