Nano‐informatics Approach to Unravel the Intrinsic Interaction of Catharanthus roseus Fabricated Zinc Oxide Nanoparticles with Vindoline to Combat Diabetes DOI
Richa Goyal, Manoj Kumar,

M. Anwar Mallick

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(48)

Published: Dec. 1, 2024

Abstract An important aspect of the treatment chronic cases diabetes is enhancement insulin secretion with a decrease in intestinal glucose absorption. In this study, prepared alcoholic Catharanthus roseus flower extract‐fabricated zinc oxide nanoparticles (FZNPs) were characterized by UV–vis spectrometer, dynamic light scattering (DLS), X‐ray diffraction (XRD), and fourier transform infrared spectroscopy (FTIR) instruments antihyperglycemic properties tested at molecular level silico method. The synthesis FZNPs possible, characterization report showed that they have maximum optical 361 nm, small grain size (15.68 nm), negative zeta potential (hydrophilic nature). hexagonal structure are surrounded several functional groups. result supports related structures, as well Zn (II) diisophthalate vindoline, good ADMET properties. Zn(II) lead interaction alpha‐glucosidase has binding affinity ‐6.3 kcal/mol, whereas vindoline KATP ‐7.4 kcal/mol. synthesized ability to inhibit targets block ion channel beta cells. reduce absorption promote secretion, so can effectively manage hyperglycaemic condition patients.

Language: Английский

Synthesis, molecular docking, assessment of biological and anti-diabetic properties of benzalacetophenone derivatives DOI Creative Commons
Wesam S. Shehab,

Nourhan Kh. R. Elhoseni,

Wael M. Aboulthana

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Language: Английский

Citations

0
Modification of photocatalytic activity and antibacterial properties of Mn2O3 by Zn ions doping DOI Creative Commons
Rabab A. Nasr,

Ahmed F. El‐Sayed,

G. M. El komy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Language: Английский

Citations

0
In silico molecular docking and ADMET prediction of biogenic zinc oxide nanoparticles: characterization, and in vitro antimicrobial and photocatalytic activity DOI Creative Commons
Hajara Akhter,

Susmita Sarker Ritu,

Shahariar Siddique

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(49), P. 36209 - 36225

Published: Jan. 1, 2024

A facile green route to synthesize zinc oxide nanoparticles using watermelon rind extract with antimicrobial and photocatalytic potential.

Language: Английский

Citations

2
Bio-preparation of CuO@ZnO nanocomposite via spent mushroom substrate and its application against Candida albicans with molecular docking study DOI Creative Commons
Emad Abada, Tarek M. Galal,

Amani Alhejely

et al.

BioResources, Journal Year: 2024, Volume and Issue: 19(3), P. 6670 - 6689

Published: July 28, 2024

Green routes for the bio-designing of bicomponent nanocomposites and their utilizations have attracted many investigators. Bio-designing CuO@ZnO was performed using spent mushroom substrate (SMS). Ultraviolet-spectrophotometry, transmission electron microscopy, Fourier transform infrared (FT-IR), energy dispersive X-ray (EDX), besides diffraction (XRD) were exploited to characterize synthesized CuO@ZnO. The dimensions ranged from 31.4 95.9 nm. Both FT-IR EDX analyses displayed presence some organic constituents SMS that joined surface fabricated nanocomposite. nanocomposite succeeded in inhibiting Candida albicans with an inhibition zone 33.5 ± 2 mm. C. biofilm affected by 25.08, 68.70, 88.56% at 25, 50, 75% minimum inhibitory concentration, respectively. Molecular docking studies showed substantial binding affinities, as well common hydrogen bonds. Optimum sites CuO ZnO nanoparticles found affinities interactions 4YDE, 3DRA, 1EAG proteins albicans, resulting in, respectively, -2.7942, -3.30097, -2.52129 kcal/mol, -3.78244, -4.6029, -4.1352 kcal/mol values. findings suggest can effectively suppress growth.

Language: Английский

Citations

0
Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels DOI Creative Commons
Amal M. El‐Feky, Wael M. Aboulthana, Ahmed A. El‐Rashedy

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 14, 2024

Language: Английский

Citations

0
Nano‐informatics Approach to Unravel the Intrinsic Interaction of Catharanthus roseus Fabricated Zinc Oxide Nanoparticles with Vindoline to Combat Diabetes DOI
Richa Goyal, Manoj Kumar,

M. Anwar Mallick

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(48)

Published: Dec. 1, 2024

Abstract An important aspect of the treatment chronic cases diabetes is enhancement insulin secretion with a decrease in intestinal glucose absorption. In this study, prepared alcoholic Catharanthus roseus flower extract‐fabricated zinc oxide nanoparticles (FZNPs) were characterized by UV–vis spectrometer, dynamic light scattering (DLS), X‐ray diffraction (XRD), and fourier transform infrared spectroscopy (FTIR) instruments antihyperglycemic properties tested at molecular level silico method. The synthesis FZNPs possible, characterization report showed that they have maximum optical 361 nm, small grain size (15.68 nm), negative zeta potential (hydrophilic nature). hexagonal structure are surrounded several functional groups. result supports related structures, as well Zn (II) diisophthalate vindoline, good ADMET properties. Zn(II) lead interaction alpha‐glucosidase has binding affinity ‐6.3 kcal/mol, whereas vindoline KATP ‐7.4 kcal/mol. synthesized ability to inhibit targets block ion channel beta cells. reduce absorption promote secretion, so can effectively manage hyperglycaemic condition patients.

Language: Английский

Citations

0