Chitosan-based Schiff base polymer derived from acetyl triazolyl uracil: Synthesis, characterization, evaluation of antimicrobial and antioxidant activities, and density functional theory calculations

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140327 - 140327

Published: Jan. 1, 2025

Language: Английский

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Thiadiazole chitosan conjugates as a novel cosmetic ingredient for rinse-off hair conditioners: design, formulation, characterization and in silico-molecular docking studies

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 19, 2025

Recently, chitosan derivatives, as eco-sustainable and renewable products, have been recorded to be highly effective toward cosmetics with potent biological activity. The main core of this research is develop an organic hair conditioner (OHC) based on two chitosan-thiadiazole conjugates, chitosan-(ethylthio‑thiadiazole) (CH-ETD) chitosan-(benzylthio‑thiadiazole) (CH-BTD), natural fragrances. A series nine OHC formulae were prepared (CH1-CH3 for OHC, E1-E3 CH-ETD B1-B3 CH-BTD OHC) characterized their visual examination, pH, thermal stability, dirt dispersion, moisturizing time, percentage solid content, irritation, rinsing, combing, the luster. results showed that pH values all 4.2-4.7 which considered acceptable avoid skin irritation. distinctive film surrounds each individual shaft in treated groups when compared control without application under a scanning electron microscope SEM magnification power 100 μm. Additionally, every single clearly covered, group exhibited noticeable issues not observed groups, no signs tangling. Due end-use performance properties formulated it can concluded formulas (CH, E2, B2) best efficacy; easier style, detangle hair, retain moisture, very thick, cause irritation or inflammation, minimize frizz, create protective barrier hair. These findings collectively validate potential formulations coupled perfumery transformative approach care, aligning consumer preferences both efficacy environmental sustainability. Furthermore, work, docking studies conducted provide theoretical proof about significant roles keratin growth cosmetic applications (skin).

Language: Английский

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Exploring the potent hydrolytic activity of chitosan-cerium complex microspheres resin for organophosphorus pesticide degradation

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33642 - e33642

Published: June 28, 2024

Chitosan is a biocompatible, non-toxic and renewable natural basic polysaccharide that can be cross-linked reacted with Ce(IV) to form physiologically active chitosan-Ce(IV) complex. To investigate this novel complex its potential hydrolyze phosphate ester bonds, chitosan-cerium microspheres resin (CS-CCMR) was prepared from chitosan ceric ammonium nitrate by reversed-phase suspension cross-linking polymerization. CS-CCMR characterized, ability disodium p-nitrobenzene (PNPP2Na) organophosphorus pesticides investigated, the hydrolytic mechanism explored. composed of dark yellow smooth surfaces dense pores. It found contained 4.507 mg/g Ce(IV), indicating coordination polymerization between successful. The presence in confirmed multiple analytical methods it mediated nitrogen atom amino group oxygen hydroxyl chitosan. shown efficiently hydrolyzed bonds PNPP2Na five pesticides. Hydrolysis potentially accomplished charge neutralization nucleophilic substitution. parathion degradation involves modification nitro give aminoparathion, followed cleavage P–O bond generate diazinphos. Consequently, exhibits great efficiency for hydrolysis expected developed as an agent reduce possibility contamination fruit vegetable drinks

Language: Английский

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Copper‐Catalyzed Chemoselective Synthesis of Pyrazolo‐Sulfonamide: Impact of Solvent on Nitro‐pyrazole Reactivity

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract This study presents a copper‐catalyzed, solvent‐dependent method for the rapid and efficient synthesis of N ‐pyrazolo‐sulfonamides directly from nitro‐pyrazole sulfonyl hydrazide under microwave conditions. The reaction exhibits notable solvent effects in pyrazole's reactivity. ionic liquid DBU‐AcOH triggered reactivity 4‐nitro‐pyrazole, whereas PEG proceeded selectively at 3‐ & 5‐positions pyrazole. Key applications this include gram‐scale pyrazolo‐sulfonamide, sulfaphenazole analogue sulfonamide nucleoside.

Language: Английский

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