Synthesis and molecular modeling of new triazole-bithiazole conjugates as antimicrobial agents DOI Creative Commons
Hadeer Mattar,

Gadeer R.S. Ashour,

Mansoor Alsahag

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101925 - 101925

Published: Nov. 1, 2024

Language: Английский

Structure–Performance Relationship of Novel Azo-Salicylaldehyde Disperse Dyes: Dyeing Optimization and Theoretical Insights DOI Creative Commons
Walid E. Elgammal, Ali A. Ali, Ahmed E. Hassan

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6876 - 6890

Published: Feb. 4, 2025

High yields of three novel azo disperse dyes based on the diazonium salt sulfonamides-azo-salicylaldehyde were successfully synthesized. These structurally characterized by using spectroscopic techniques, including FTIR, 1H NMR, and MS. The fundamental goal research was to determine optimal dyeing parameters, such as temperature, pH, time, understand behavior dispersed 13–15 during polyester materials. results showed that increasing temperature from 100 130 °C significantly improved dyed polyester's color strength (K/S values). colored samples' hues ranged beige yellowish brown dark due coupler molecules other parameters duration, pH. Moreover, substituents main dye structures investigated studying change in data (CILAB), reflectance, (K/S) evaluations polyester-dyed fabrics. Experimental indicate 15 achieves highest intensity reflectivity, correlating with its narrower band gap enhanced electrophilic/nucleophilic reactivity, revealed DFT TD-DFT calculations. findings highlight relationship between structure performance, demonstrating superior dye–fiber interactions stability contribute performance. synthesized present promising candidates for imparting diverse, stable colors excellent fastness wash, light, crock

Language: Английский

Citations

1
Investigation on synthesized sulfonamide Schiff base with DFT approaches and in silico pharmacokinetic studies: Topological, NBO, and NLO analyses DOI Creative Commons

Md. Minhazul Abedin,

Tarun Kumar Pal, Md. Chanmiya Sheikh

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34499 - e34499

Published: July 1, 2024

The sulfonamide Schiff base (C

Language: Английский

Citations

4
Synthesis, Molecular modelling, and antimicrobial activity of new triazole-thiophene compounds DOI
Matokah M. Abualnaja,

Shaker T. Alsharif,

Alaa M. Alqahtani

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141898 - 141898

Published: Feb. 1, 2025

Language: Английский

Citations

0
Solution‐Phase and Mechanochemical Synthesis and Antimicrobial Activity of New Thiazolo[3,2‐a]Pyridine‐6‐Sulfonamides DOI
Cevher Altuğ, Muhammet Büyükbayram,

Özge Kavas

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract This study focuses on the development of environmentally friendly and efficient synthetic routes for novel thiazolo[3,2‐ a ]pyridine‐6‐sulfonamide derivatives with potential antimicrobial properties. Using one‐pot multi‐component approach, these heterocyclic compounds were synthesized both in solution under solvent‐free mechanochemical conditions. Reactions between 1‐(4‐oxothiazolidin‐2‐ylidene)‐ N ‐phenylmethane sulfonamide, malononitrile, aryl aldehydes led to two distinct classes sulfonamides depending stoichiometry used. A range compounds, along structurally related analogues, was evaluated activity against Escherichia coli , Staphylococcus aureus Pseudomonas aeruginosa Bacillus cereus . Five demonstrated significant activity, particularly S. highlighting their as lead new antibacterial agents.

Language: Английский

Citations

0
Benzothiazole derivatives as inhibitors of chikungunya virus replicative cycle DOI

Shiraz Feferbaum-Leite,

Natasha Marques Cassani, Uriel Enrique Aquino Ruiz

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: May 16, 2025

Chikungunya virus (CHIKV) is the agent of chikungunya fever (CHIKF), a reemerging disease prevalent in tropical regions. With no licensed treatments available, identifying effective antiviral compounds critical. This study evaluates potential 20 synthetic sulfonamide derivatives against CHIKV. We tested 13 heteroaromatic containing thiazole, benzimidazole, and benzothiazole (BTA) moieties, along with seven sulfonamides bearing ester carboxylic acid groups. CHIKV-nanoluc replication was assessed vitro, molecular docking infrared spectroscopy studies were conducted to explore interactions viral proteins. BTA 6, 9, 11, demonstrated potent CHIKV inhibition, EC50 values between 14.9 63.1 µM selective indexes 13.8, 5.8, 4.4, respectively. All acted post-entry stage, compound 9 reducing by 98%. Compound exhibited multi-stage activity, inhibiting through virucidal (55%), pre-treatment (69%), entry (98%) mechanisms. Molecular suggested strong binding affinities non-structural proteins envelope glycoproteins. Infrared corroborated 9's interaction glycoprotein complex lipids. These findings highlight as promising inhibitors. ability interfere at multiple stages infection suggests its for therapeutic development CHIKF.

Language: Английский

Citations

0
Molecular modeling and antimicrobial activity of newly synthesized benzothiazole-thiazole conjugates DOI
Arwa Alharbi,

Mansoor Alsahag,

Ali Alisaac

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 115852 - 115852

Published: June 22, 2024

Language: Английский

Citations

2
Unlocking the Potential of Pyrrole: Recent Advances in New Pyrrole-Containing Compounds with Antibacterial Potential DOI Open Access
Aura Rusu, Octavia-Laura Moldovan, Corneliu Tanase

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12873 - 12873

Published: Nov. 29, 2024

Nitrogen heterocycles are valuable structural elements in the molecules of antibacterial drugs approved and used to treat bacterial infections. Pyrrole is a five-atom heterocycle found many natural compounds with biological activity, including activity. Numerous being develop based on pyrrole as new potential drugs. Due phenomenon resistance, there continuous need create effective antibacterials. In scientific literature, we have identified most relevant studies that aim compounds, such derivatives, proven Nature an endless reservoir inspiration for designing structure calcimycin, lynamycins, marinopyrroles, nargenicines, phallusialides, others. However, other synthetic been developed can be optimized future. The were classified according type chemical structure. structure-activity relationships, mechanisms action, effectiveness highlighted. This review highlights progress pyrrole-containing provides examples lead successfully further.

Language: Английский

Citations

2
Synthesis of New Imidazolo‐Benzenesulfonamide Linked 1,2,3‐Triazoles as Potent Antibacterial and Antibiofilm Agents DOI

N. Ramu,

Rambabu Palabindela, Ravikumar Kapavarapu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(38)

Published: Oct. 1, 2024

Abstract In search of better antibacterial and antibiofilm agents, this report presents a series novel 1,2,3‐triazole‐imidazole‐benzenesulfonamide derivatives that were synthesized evaluated for their activity in vitro. Antibacterial against three Gram‐positive bacterial strains, B. subtilis , S. aureus epidermidis was evaluated. Among all the tested compounds, 4‐methyl‐ N ‐(1‐methyl‐1 H ‐imidazol‐2‐yl)‐ ‐((1‐(4‐(trifluoromethyl)phenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)benzenesulfonamide ‐((1‐(3,5‐difluorophenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)‐4‐methyl‐ ‐imidazol‐2‐yl)benzenesulfonamide exhibited potent strains. Biofilm profiles compounds it observed from results above two active displayed promising biofilm inhibition with MIC values ranging between 2.19 ± 0.37 3.38 0.35 µg/mL. Furthermore, screened silico molecular docking studies penicillin‐binding protein compound ‐((1‐(3,5‐dichlorophenyl)‐1 show highest binding energy as compared to standard remaining compounds.

Language: Английский

Citations

0
Synthesis and molecular modeling of new triazole-bithiazole conjugates as antimicrobial agents DOI Creative Commons
Hadeer Mattar,

Gadeer R.S. Ashour,

Mansoor Alsahag

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101925 - 101925

Published: Nov. 1, 2024

Language: Английский

Citations

0