Human Gene, Journal Year: 2024, Volume and Issue: unknown, P. 201372 - 201372
Published: Dec. 1, 2024
Language: Английский
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 10, 2025
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1611 - 1611
Published: Sept. 26, 2024
The constant increase in the elderly population presents significant challenges addressing new social, economic, and health problems concerning this population. With respect to health, aging is a primary risk factor for age-related diseases, which are driven by interconnected molecular hallmarks that influence development of these diseases. One main mechanisms has attracted more attention autophagy, catabolic process removes recycles damaged or dysfunctional cell components preserve viability. autophagy can be induced deregulated response wide range internal external stimuli, such as starvation, oxidative stress, hypoxia, organelles, infectious pathogens, aging. Natural compounds promote stimulation regulatory pathways, mTOR, FoxO1/3, AMPK, Sirt1, lead increased levels essential proteins Beclin-1 LC3, well decrease p62. These changes indicate activation autophagic flux, known decreased cardiovascular neurodegeneration, cataracts. regulated administration natural offers an adjuvant therapeutic alternative diseases; however, experimental evidence needed support confirm benefits. Hence, review aims highlight potential benefits regulating pathways approach combating
Language: Английский
Citations
4
Separations, Journal Year: 2025, Volume and Issue: 12(2), P. 34 - 34
Published: Jan. 28, 2025
Quercetin in Taraxacum mongolicum was extracted by ultrasound-assisted extraction synergy with an ionic liquid–enzyme complex system, and the antioxidant function of quercetin investigated based on network pharmacology. From 1-butyl-3-methylimidazolium chloride, acetate, tetrafluoroborate, bromide, first step to choose appropriate liquid. Subsequently, a response surface methodology single-factor experiment were used optimize process. The key targets for antioxidants obtained from public database. Antioxidant activity assessed measuring scavenging rate 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals hydroxyl radicals(•OH). approach revealed that optimal process liquid–solid ratio 31.62:1 mL/g, enzymatic temperature 55 °C, amount cellulase added 14.79% dry weight dandelion. Under this condition, yield 0.24 ± 0.011 mg/g, which 1.3 times higher than conventional reflux method 0.185 0.015 mg/g. Pharmacological findings showed 57 cross-targets antioxidants. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis indicated may be related chemical carcinogenesis-reactive oxygen species, Phosphoinositide 3-kinase/protein kinase B signaling pathway. has strong DPPH •OH radical activity. development use industrial dandelion are supported sustainable effective extracting
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113320 - 113320
Published: March 1, 2025
Language: Английский
Citations
0
Letters in Drug Design & Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100004 - 100004
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 601 - 601
Published: Jan. 12, 2025
This study investigates the biorefinery approach to extracting blood–brain barrier (BBB)-permeable compounds from Eucalyptus globulus Labill. and Salvia officinalis L. for neuroprotective purposes. A sequential extraction process was applied, starting with supercritical CO2 (SC-CO2) obtain non-polar terpenoids, followed by pressurized natural deep eutectic solvent (PLE-NaDES) recover phenolic SC-CO2 residue. PLE-NaDES extracts exhibited higher antioxidant anticholinergic capacities than both plants, S. being more bioactive E. extracts. total of 21 terpenoids were identified using gas chromatography–mass spectrometry while 24 detected In addition, 25 different in plants high-performance liquid chromatography coupled mass The permeability across BBB showed limited obtained plants; however, polar high permeability, particularly flavonoids rosmarinic acid officinalis. revealed, first time, potential PLE-NaDES, as well when crossing exert their protective effects. research opens a new pathway exploring alternatives current drugs used treating neurodegenerative diseases.
Language: Английский
Citations
0
Phytochemical Analysis, Journal Year: 2025, Volume and Issue: unknown
Published: May 26, 2025
ABSTRACT Introduction Crateva magna ( Cm ) was utilized as a folkloric medicine against neurological disorders. Objectives This study aimed to investigate the phytochemical profile of leaf extract and its endophytic fungus, Nigrospora oryzae No extract. Additionally, neuroprotective potential their optimized bilosomes (BLs) will be assessed an approach Alzheimer's disease AD treatment. Materials Methods UPLC‐ESI‐MS/MS chemical profiling performed. In vitro anti‐Alzheimer activity extracts evaluated AChE BACE1 enzymes. ‐BLs were prepared using thin‐film hydration technique. vivo in streptozotocin (STZ)‐induced sporadic mouse model. Behavioral assays, neurochemical RT‐PCR analysis, histopathological examination, immunohistochemical analysis Results Chemical revealed diverse metabolites from various classes. The major class identified flavonoids, e.g., kaempferol‐ O ‐hexoside, whereas extract, it alkaloids, phenazine carboxamide. neuropathological markers (A β 1–42, IL‐6, p‐Tau protein) reduced by ≈50% 60% mice receiving ‐BLs, respectively, relative STZ group. Also, BLs exhibited greatest ability downregulate expression p‐JNK, p‐P38, p‐ERK brain. Histopathological examination that showed highest protection for hippocampus cerebral cortex regions. significantly decreased reaction NFκB neurons. Conclusion exhibit considerable novel adjuvant therapies , utilizing natural bioactive compounds improve efficiency targeted drug delivery enhance therapeutic outcomes.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Aug. 30, 2024
Migraine is a debilitating neurological disorder impacting millions worldwide. Calcitonin Gene-Related Peptide (CGRP) has emerged as key player in migraine pathophysiology, leading to the development of targeted therapies. This study reviews novel CGRP-targeted treatments, including monoclonal antibodies small molecule inhibitors/nutraceuticals and introduces Asarinin potential modulator pathway. Asarinin, natural compound found various plants, examined for its pharmacological management. Pharmacokinetic assessments, toxicological modelling, molecular property analysis, network pharmacology were conducted. Molecular docking dynamics studies with CGRP reveal interactions, providing foundation understanding Asarinin's therapeutic effects. favourable pharmacokinetics, safety profile, bioactivity, supporting candidacy agent. In-depth receptor (PDB: 6ZHO) demonstrate strong binding affinity (- 10.3kcal/mol), while simulations unveil dynamic behavior Asarinin-CGRP complex, 10.53 kcal/mol) Atogepant-CGRP complex. Network analysis highlights proteins pathology, indicating efficacy. The groundwork future investigations, suggests promising candidate management by targeting OPRM1 integration diverse assessments provides comprehensive paves way further preclinical clinical research.
Language: Английский
Citations
2
Aspects of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100060 - 100060
Published: Dec. 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13076 - 13076
Published: Dec. 5, 2024
Quercetin, a well-known flavonoid with significant medicinal potential, was derivatized at the C8 position tetrahydroisoquinoline (THIQ) moiety, and physicochemical pharmacological properties, inhibition antioxidant activity, cytotoxicity of new compounds were evaluated. Physicochemical including lipophilicity, membrane permeability, P-glycoprotein substrate affinity, assessed theoretically using SwissADME software. The metal-chelating ability evaluated on metal ions Fe
Language: Английский
Citations
1