Comparison of infrared heating and hot air frying for creating novel puffed snacks from Bengal gram and garbanzo grains

Vegetos, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

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Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 28, 2025

Abstract Duranta erecta Linn. belongs to the Verbenaceae family and is primarily found in subtropical, tropical, temperate climates. The plant has been reported contain a variety of phytoconstituents, including iridoid glycosides, flavonoids, flavonoid alkaloids, phenolics, tannins, terpenoids, steroids, saponins. In this investigation, bioactivity-guided isolation was used isolate cyclooxygenases (COXs) lipoxygenase (LOX)-inhibiting compounds from leaves Duranterectoside A ( 1 ), lamiide 2 apigenin 4’,7-dimethyl ether 3 ) were identified employing spectroscopic methods (including ESI-MS, H-NMR, 13 C-NMR), by comparing with existing literature data. This first report metabolitrs D. inhibiting both LOX COX enzymes. Furthermore, isolated analyzed using computerized virtual screening, which enabled modelling ADME characteristics, molecular docking, dynamics simulation. results demonstrated that compound had greater docking scores than docked lead compounds. Overall, data study add our understanding pharmacological properties examined pave way for future research investigation inflammation drug discovery.

Language: Английский

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Donepezil-Based Rational Design of N-Substituted Quinazolinthioacetamide Candidates as Potential Acetylcholine Esterase Inhibitors for the Treatment of Alzheimer’s Disease: In vitro and In vivo Studies

RSC Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Donepezil-based rational design of N -substituted quinazoline tethered thioacetamide as potential acetylcholine esterase inhibitors for the treatment Alzheimer's disease.

Language: Английский

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The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10041 - 10041

Published: Sept. 18, 2024

The objective of this review is to provide a comprehensive examination the role microbial metabolites in progression neurodegenerative diseases, as well investigate potential therapeutic interventions targeting microbiota. A literature search was conducted across following databases: PubMed, Scopus, Web Science, ScienceDirect, and Wiley. Key terms related gut microbiota, metabolites, specific metabolic products were used. included both preclinical clinical research articles published between 2000 2024. Short-chain fatty acids have been demonstrated play crucial modulating neuroinflammation, preserving integrity blood–brain barrier, influencing neuronal plasticity protection. Furthermore, amino their derivatives exert significant influence on CNS function. These impact health by regulating intestinal permeability, immune responses, directly neuroinflammation oxidative stress, which are integral diseases. Therapeutic strategies, including prebiotics, probiotics, dietary modifications, fecal microbiota transplantation confirmed restore balance enhance production neuroprotective metabolites. novel drug developments based present promising avenues. its represent field with advance our understanding develop treatments for

Language: Английский

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Impact of cultivar types and thermal processing methods on sweet potato metabolome, a comparative analysis via a multiplex approach of NIR and GC–MS based metabolomics coupled with chemometrics

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141125 - 141125

Published: Sept. 7, 2024

Language: Английский

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