Developments of polyurethane in biomedical applications: A review

Resources Chemicals and Materials, Journal Year: 2023, Volume and Issue: 2(4), P. 262 - 276

Published: July 17, 2023

Polyurethane is an excellent and widely used polymer material. In synthesizing polyurethane, the structure of soft hard segments in polyurethane could be adjusted, which can obtain better properties than other materials, such as good mechanical biocompatibility. recent years, due to their chemical stability, biocompatibility, low cytotoxicity, polyurethanes have been for biomedical applications. To solve problems degradation recycling, development bio-based has also become a current hot spot. This paper summarizes research progress applications materials dressings, skin sensors, orthopedics, cardiovascular. It looks forward future medical materials.

Language: Английский

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Materials and Structural Designs toward Motion Artifact-Free Bioelectronics

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(10), P. 6148 - 6197

Published: May 1, 2024

Bioelectronics encompassing electronic components and circuits for accessing human information play a vital role in real-time continuous monitoring of biophysiological signals electrophysiology, mechanical physiology, electrochemical physiology. However, noise, particularly motion artifacts, poses significant challenge accurately detecting analyzing target signals. While software-based "postprocessing" methods signal filtering techniques have been widely employed, challenges such as distortion, major requirement accurate models classification, power consumption, data delay inevitably persist. This review presents an overview noise reduction strategies bioelectronics, focusing on reducing artifacts improving the signal-to-noise ratio through hardware-based approaches "preprocessing". One main stress-avoiding is elastic energies applied to bioelectronics prevent stress-induced artifacts. Various including strain-compliance, strain-resistance, stress-damping using unique materials structures explored. Future research should optimize structure designs, establish stable processes measurement methods, develop selectively separating processing overlapping noises. Ultimately, these advancements will contribute development more reliable effective healthcare diagnostics.

Language: Английский

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Flexible Strain Sensors Based on an Interlayer Synergistic Effect of Nanomaterials for Continuous and Noninvasive Blood Pressure Monitoring

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 26943 - 26953

Published: May 8, 2024

The continuous, noninvasive monitoring of human blood pressure (BP) through the accurate detection pulse waves has extremely stringent requirements on sensitivity and stability flexible strain sensors. In this study, a new ultrasensitive sensor based interlayer synergistic effect was fabricated drop-casting drying silver nanowires graphene films polydimethylsiloxane substrates further successfully applied for continuous BP. This exhibited ultrahigh with maximum gauge factor 34357.2 (∼700% enhancement over other major sensors), satisfactory response time (∼85 ms), wide strange range (12%), excellent stability. An fracture mechanism proposed to elucidate working principle sensor. real-time BP values can be obtained by analyzing relationship between transit time. To verify our monitoring, compared conventional electrocardiogram–photoplethysmograph method commercial cuff-based device showed similar measurement results from both methods, only minor differences 0.693, 0.073, 0.566 mmHg in systolic BP, diastolic mean arterial pressure, respectively. Furthermore, reliability sensors validated testing 20 subjects more than 50 min. provides pathway monitoring.

Language: Английский

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Traditional Chinese Medicine (TCM)‐Inspired Fully Printed Soft Pressure Sensor Array with Self‐Adaptive Pressurization for Highly Reliable Individualized Long‐Term Pulse Diagnostics

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Reliable, non‐invasive, continuous monitoring of pulse and blood pressure is essential for the prevention diagnosis cardiovascular diseases. However, wave varies drastically among individuals or even over time in same individual, presenting significant challenges existing sensing systems. Inspired by methods traditional Chinese medicine (TCM), this work reports a self‐adaptive platform (PSP) that combines fully printed flexible sensor array with an adaptive wristband‐style system can identify optimal signal. Besides detected rate/width/length, “Cun, Guan, Chi” position, “floating, moderate, sinking” features, PSP combined machine learning‐based linear regression model also accurately predict such as systolic, diastolic, mean arterial values. The developed diagnostic demonstrated highly reliable long‐term analysis across multiple human subjects time. design concept proof‐of‐the‐concept demonstrations pave way future developments devices/systems individualized complex practical environments personalized medicine, along support development digital TCM.

Language: Английский

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Wearable bioelectronics based on emerging nanomaterials for telehealth applications

Device, Journal Year: 2025, Volume and Issue: 3(1), P. 100676 - 100676

Published: Jan. 1, 2025

The bigger pictureNanomaterial-driven, soft wearable electronics hold great promise for continuous monitoring of bio-signals, efficient collection physiological data, and on-demand drug delivery. Wearable electronic devices transducing responses into electrical signals have been used in various telemedicine telediagnosis applications, such as real-time vital signs, blood pressure, body temperature, human motion. Combined with radio frequency (RF) technologies, these can transmit health data be powered wirelessly. In this review, we discuss the recent progress one- two-dimensional nanomaterials their intriguing electrical, biochemical, thermal, mechanical properties that make them suitable applications. Human sensing networks built may enable long-term, multi-physiological monitoring, thus facilitating comprehensive across metrics.SummaryNanomaterial-driven, bioelectronics are transforming by offering skin comfort, biocompatibility, capability remote signals. devices, enabled advanced zero-dimensional (0D), one-dimensional (1D), (2D) nanomaterials, achieved new levels stability reliability, allowing to perform effectively even under dynamic physical conditions. Despite promise, significant challenges remain fabrication, integration, practical deployment nanoscale materials devices. Critical include ensuring durability nanomaterial-based extended wear developing integration strategies support multifunctional modalities. Telemedicine has revolutionized healthcare enabling monitoring. within is a central factor driving breakthrough, enhance sensor sensitivity, durability, multifunctionality. These sensors leverage operating principles tailored specific intraocular pressure electrophysiological signal recording, biochemical marker tracking.Graphical abstract

Language: Английский

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