End-to-end design of wearable sensors

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(11), P. 887 - 907

Published: July 22, 2022

Language: Английский

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Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

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3D printable high-performance conducting polymer hydrogel for all-hydrogel bioelectronic interfaces

Nature Materials, Journal Year: 2023, Volume and Issue: 22(7), P. 895 - 902

Published: June 15, 2023

Language: Английский

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Solution-processable, soft, self-adhesive, and conductive polymer composites for soft electronics

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 18, 2022

Abstract Soft electronics are rising electronic technologies towards applications spanning from healthcare monitoring to medical implants. However, poor adhesion strength and significant mechanical mismatches inevitably cause the interface failure of devices. Herein we report a self-adhesive conductive polymer that possesses low modulus (56.1-401.9 kPa), high stretchability (700%), interfacial (lap-shear >1.2 MPa), conductivity (1-37 S/cm). The is fabricated by doping poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) composite with supramolecular solvent (β-cyclodextrin citric acid). We demonstrated solution process-based fabrication polymer-based electrodes for various soft devices, including alternating current electroluminescent electromyography monitoring, an integrated system visualization signals during muscle training array show promising features further develop wearable comfortable bioelectronic devices physiological electric human body readable displayable daily activities.

Language: Английский

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Flexible Accelerated‐Wound‐Healing Antibacterial MXene‐Based Epidermic Sensor for Intelligent Wearable Human‐Machine Interaction

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(47)

Published: Sept. 17, 2022

Abstract Flexible epidermic sensors made from conductive hydrogels are holding bright potential in personalized healthcare, multifunctional electronic skins, and human‐machine interfaces. However, it is still a great challenge to simultaneously realize hydrogel‐based with reliable self‐healing ability remarkable sensing performances high‐performance healthcare (especially electrophysiological signals) for wearable interaction, as well accelerated wound healing subsequent medical treatment together. Herein, flexible healable sensor assembled the facilely prepared antibacterial MXene hydrogel efficiently sensitively interaction. The as‐prepared possesses enhanced mechanical performance, outstanding capability, injectability, facile degradability, excellent biocompatibility, robust ability, which capable of being into monitor human movements rehabilitation training, detect tiny signals diagnosis cardiovascular‐ muscle‐related diseases, be employed In addition, can utilized treat infection effectively accelerate healing. Thus, sheds light on preparing integration personal health smart interaction next‐generation artificial skins.

Language: Английский

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Ultra‐High Electrical Conductivity in Filler‐Free Polymeric Hydrogels Toward Thermoelectrics and Electromagnetic Interference Shielding

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(12)

Published: Jan. 22, 2022

Conducting hydrogels have attracted much attention for the emerging field of hydrogel bioelectronics, especially poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT:PSS) based hydrogels, because their great biocompatibility and stability. However, electrical conductivities are often lower than 1 S cm-1 which not suitable digital circuits or applications in bioelectronics. Introducing conductive inorganic fillers into can improve conductivities. it may lead to compromises compliance, biocompatibility, deformability, biodegradability, etc. Herein, a series highly ionic liquid (IL) doped PEDOT:PSS without any is reported. These exhibit high up ≈305 , ≈8 times higher record polymeric literature. The conductivity results enhanced areal thermoelectric output power hydrogel-based devices, specific electromagnetic interference (EMI) shielding efficiency about an order magnitude that state-of-the-art Furthermore, these stretchable (strain >30%) fast self-healing, shape/size-tunable properties, desirable bioelectronics wearable organic devices. indicate promising such as sensing, thermoelectrics, EMI shielding,

Language: Английский

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Highly adhesive and self-healing γ-PGA/PEDOT:PSS conductive hydrogels enabled by multiple hydrogen bonding for wearable electronics

Nano Energy, Journal Year: 2022, Volume and Issue: 95, P. 106991 - 106991

Published: Jan. 29, 2022

Language: Английский

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A self-healing electrically conductive organogel composite

Nature Electronics, Journal Year: 2023, Volume and Issue: 6(3), P. 206 - 215

Published: March 9, 2023

Language: Английский

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Strong Tough Polyampholyte Hydrogels via the Synergistic Effect of Ionic and Metal–Ligand Bonds

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(37)

Published: June 29, 2021

Abstract Despite existing in biological systems, developing synthetic polyampholyte (PA) hydrogels constructed by both ionic and metal–ligand bonds remains challenging. Herein, a simple secondary equilibrium approach is proposed to fabricate strong tough PA via the synergy of bonds. The original gels (constructed bonds) are first dialyzed multivalent metal‐ion solutions reach swelling then moved deionized water dialyze excess free ions achieve new equilibrium. Through this approach, gel network can be optimized eventually bonds, enabling synergistic reinforcement. By selecting different systems diverse metal‐ions, proved generalizable gels. Additionally, have stable ion‐conductivity even at water‐equilibrium state, making them promising as strain sensors. viscoelastic elastic contributions mechanical properties model also discussed further understand strengthening toughening mechanisms. strategy but effective for achieving PA‐based hydrogels. This study provides insights electrolyte environments.

Language: Английский

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