International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 6847 - 6868
Published: Nov. 1, 2023
Abstract:
Lipid-structured
vesicles
have
been
applied
for
drug
delivery
system
over
50
years.
Based
on
their
origin,
lipid-structured
are
divided
into
two
main
categories,
namely
synthetic
lipid
(SLNVEs)
and
of
mammalian
origin
(MDVEs).
Although
SLNVEs
can
stably
transport
anti-cancer
drugs,
biocompatibility
is
poor
degradation
exogenous
substances
a
potential
risk.
Unlike
SLNVEs,
MDVEs
excellent
but
limited
by
lack
stability
risk
contamination
dangerous
pathogens
from
donor
cells.
Since
the
first
discovery
plant-derived
(PDVEs)
in
carrot
cell
supernatants
1967,
emerging
evidence
has
shown
that
PDVEs
integrate
advantages
both
MDVEs.
Notably,
55
years
dedicated
research
indicated
an
ideal
candidate
vesicle
preparation,
transport,
disease
treatment.
The
current
review
systematically
focuses
role
cancer
therapy
particular
compares
properties
with
those
conventional
vesicles,
summarizes
preparation
methods
quality
control
PDVEs,
discusses
application
delivering
drugs
underlying
molecular
mechanisms
therapy.
Finally,
challenges
future
perspectives
development
novel
therapeutic
strategies
against
discussed.
Keywords:
therapy,
delivery,
liposome
nanoparticles,
mammalian-derived
exosomes
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
190, P. 106733 - 106733
Published: March 15, 2023
Natural
compounds
are
widely
used
to
prevent
and
treat
various
diseases
due
their
antioxidant
anti-inflammatory
effects.
As
a
kind
of
promising
natural
compound,
plant-derived
exosome-like
nanoparticles
(PELNs)
extracted
from
multivesicular
bodies
edible
plants,
including
vegetables,
foods,
fruits,
mainly
regulate
the
cellular
immune
response
pathogen
attacks.
Moreover,
PELNs
could
remarkably
interfere
with
dynamic
imbalance
between
pro-inflammatory
effects,
facilitating
maintain
homeostasis
microenvironment.
may
serve
as
better
alternative
animal-derived
exosomes
(ADEs)
owing
widespread
sources,
cost-effectiveness,
easy
accessibility.
can
mediate
interspecies
communication
by
transferring
cargoes
such
proteins,
lipids,
nucleic
acids
plant
cells
mammalian
cells.
This
review
summarizes
biogenesis,
composition,
classification
exosomes;
common
separation,
purification,
characterization
methods
PELNs,
potential
advantages
over
ADEs;
immunomodulatory
functions
in
colitis,
cancer,
inflammation-associated
metabolic
diseases.
Additionally,
future
perspectives
challenges
associated
clinical
application
discussed.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 10, 2022
Periodontitis
is
an
infectious
oral
disease,
which
leads
to
the
destruction
of
periodontal
tissues
and
tooth
loss.
Although
treatment
periodontitis
has
improved
recently,
effective
periodontitis-affected
still
a
challenge.
Therefore,
it
urgent
explore
new
therapeutic
strategies
for
periodontitis.
Natural
products
show
anti-microbial,
anti-inflammatory,
anti-oxidant
bone
protective
effects
most
these
natural
are
safe
cost-effective.
Among
these,
plant-derived
exosome-like
nanoparticles
(PELNs),
type
nanocarriers
repleted
with
lipids,
proteins,
RNAs,
other
active
molecules,
ability
enter
mammalian
cells
regulate
cellular
activities.
Reports
from
literature
indicate
great
potential
PELNs
in
regulation
immune
functions,
inflammation,
microbiome,
tissue
regeneration.
Moreover,
can
also
be
used
as
drug
carriers
enhance
stability
uptake
vivo.
Since
function,
regeneration
key
phenomena
usually
targeted
during
treatment,
hold
promising
treatment.
This
review
summarizes
recent
advances
PELNs-related
research
that
related
periodontitis-destructed
underlying
mechanisms.
We
discuss
existing
challenges
prospects
application
PELNs-based
approaches
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 29, 2023
Abstract
Background
The
past
few
years
have
witnessed
a
significant
increase
in
research
related
to
plant-derived
extracellular
vesicles
(PDEVs)
biological
and
medical
applications.
Using
biochemical
technologies,
multiple
independent
groups
demonstrated
the
important
roles
of
PDEVs
as
potential
mediators
involved
cell-cell
communication
exchange
bio-information
between
species.
Recently,
several
contents
been
well
identified
PDEVs,
including
nucleic
acids,
proteins,
lipids,
other
active
substances.
These
cargoes
carried
by
could
be
transferred
into
recipient
cells
remarkably
influence
their
behaviors
associated
with
human
diseases,
such
cancers
inflammatory
diseases.
Main
body
abstract
This
review
summarizes
latest
updates
regarding
focuses
on
its
role
nanomedicine
applications,
drug
delivery
strategies
develop
diagnostic
therapeutic
agents
for
clinical
management
especially
like
cancers.
Conclusion
Considering
unique
advantages,
high
stability,
intrinsic
bioactivity
easy
absorption,
further
elaboration
molecular
mechanisms
factors
driving
function
will
provide
new
horizons
treatment
disease.
Özgür Yayınları eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 29, 2023
Artificial
intelligence,
one
of
the
Industry
4.0
technologies,
is
expanding
its
place
in
our
lives
day
by
day.
intelligence
used
effectively
many
areas
life
today.
It
to
make
people's
jobs
easier,
increase
efficiency,
solve
complex
problems
and
new
discoveries.
For
example,
artificial
technology
innovation,
industry,
healthcare
sector
education.
The
basis
expert
systems,
robotics,
natural
language
processing,
computer
vision,
speech
understanding.
Techniques
include
machine
learning,
neural
networks,
deep
genetic
algorithms
fuzzy
algorithms.
This
study
has
been
prepared
explain
detail
definition,
foundations
techniques
which
almost
every
field
In
this
context,
definition
strong
weak
history
basics
are
explained.
last
section,
a
general
evaluation
was
made.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116543 - 116543
Published: April 11, 2024
In
recent
years,
there
has
been
an
increasing
number
of
related
studies
on
exosomes.
Most
have
focused
exosomes
derived
from
mammals,
confirming
the
important
role
that
play
in
cell
communication.
Plants,
as
a
natural
ingredient,
plant-derived
confirmed
to
similar
structures
and
functions
mammalian-derived
Plant-derived
exosome-like
nanoparticles
(PELNs)
are
lipid
bilayer
membrane
nanovesicles
containing
bioactive
constituents
such
miRNA,
mRNA,
protein,
lipids
obtained
plant
cells,
can
participate
intercellular
communication
mediate
transboundary
communication,
high
bioavailability
low
immunogenicity,
relatively
safe,
shown
maintaining
homeostasis
preventing,
treating
variety
diseases.
this
review,
we
describe
biogenesis,
isolation
purification
methods,
structural
composition,
stability,
safety,
function
PELNs
challenges.
The
anti-inflammatory,
antioxidant,
antitumor
drug
delivery
mainly
described,
status
research
exosome
Chinese
herbal
medicines
is
outlined.
Overall,
summarized
importance
latest
results
field
provided
theoretical
basis
for
future
clinical
application
PELNs.
Materials Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
pursuit
of
effective
drug
delivery
systems
is
critical
in
advancing
cancer
therapies,
particularly
the
realms
chemotherapy,
radiotherapy
and
immunotherapy.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(4), P. 498 - 498
Published: April 6, 2021
Plants
produce
different
types
of
nano
and
micro-sized
vesicles.
Observed
for
the
first
time
in
60s,
plant
microvesicles
(PDVs)
their
biological
role
have
been
inexplicably
under
investigated
a
long
time.
Proteomic
metabolomic
approaches
revealed
that
PDVs
carry
numerous
proteins
with
antifungal
antimicrobial
activity,
as
well
bioactive
metabolites
high
pharmaceutical
interest.
also
shown
to
be
involved
intercellular
transfer
small
non-coding
RNAs
such
microRNAs,
suggesting
fascinating
mechanisms
long-distance
gene
regulation
horizontal
regulatory
inter-kingdom
communications.
High
loading
capacity,
intrinsic
activities,
biocompatibility,
easy
permeabilization
cell
compartments
make
plant-derived
vesicles
excellent
natural
or
bioengineered
nanotools
biomedical
applications.
Growing
evidence
indicates
may
exert
anti-inflammatory,
anti-oxidant,
anticancer
activities
vitro
vivo
models.
In
addition,
clinical
trials
are
currently
progress
test
effectiveness
EVs
reducing
insulin
resistance
preventing
side
effects
chemotherapy
treatments.
this
review,
we
concisely
introduce
PDVs,
discuss
shortly
most
important
physiological
roles
plants
provide
clues
on
use
bioengineering
develop
innovative
therapeutic
tools
nanomedicine,
able
encompass
current
drawbacks
delivery
systems
nutraceutical
technology.
Finally,
predict
advent
intense
research
efforts
disclose
new
frontiers
biotechnology
applied
nanomedicine.
