Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
103(1)
Published: Dec. 13, 2023
Abstract
As
an
expert
in
the
field
of
drug
design
and
discovery,
I
tried,
this
up‐to‐date
perspective
or
commentary
article,
to
recap
shed
light
on
previous
latest
revolutionary
strategies
employed
medicinal
therapeutic
chemistry
target
principal
viral
weapon
used
by
virulent
RNA
viruses
(e.g.,
severe
acute
respiratory
syndrome
coronavirus
2
“SARS‐CoV‐2”)
infect
humans
spread
infections,
genomic
strands.
These
act
taking
advantage
weakness
points
attractive
bioweapon
disable
attack
it
(itself),
accordingly
stop
entire
reproduction,
effectively
end
microbial
infections
such
as
disease
2019
(COVID‐19).
The
generation
respective
slightly
falsely‐weaved
strands,
either
endogenously
exogenously,
is
key
for
designing
most
these
approaches.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: June 28, 2022
Abstract
The
persistent
COVID-19
pandemic
since
2020
has
brought
an
enormous
public
health
burden
to
the
global
society
and
is
accompanied
by
various
evolution
of
virus
genome.
consistently
emerging
SARS-CoV-2
variants
harboring
critical
mutations
impact
molecular
characteristics
viral
proteins
display
heterogeneous
behaviors
in
immune
evasion,
transmissibility,
clinical
manifestation
during
infection,
which
differ
each
strain
endow
them
with
distinguished
features
populational
spread.
Several
variants,
identified
as
Variants
Concern
(VOC)
World
Health
Organization,
challenged
efforts
on
control
due
rapid
worldwide
spread
enhanced
evasion
from
current
antibodies
vaccines.
Moreover,
recent
Omicron
variant
even
exacerbated
anxiety
continuous
pandemic.
Its
significant
medical
treatment
disease
highlights
necessity
combinatory
investigation
mutational
pattern
influence
dynamics
against
immunity,
would
greatly
facilitate
drug
vaccine
development
benefit
policymaking.
Hence
this
review,
we
summarized
characteristics,
impacts
focused
parallel
comparison
different
profile,
transmissibility
tropism
alteration,
effectiveness,
manifestations,
order
provide
a
comprehensive
landscape
for
research.
Journal of Biological Chemistry,
Journal Year:
2023,
Volume and Issue:
299(3), P. 103004 - 103004
Published: Feb. 10, 2023
SARS-CoV-2
is
the
causative
agent
of
COVID-19.
The
main
viral
protease
(Mpro)
an
attractive
target
for
antivirals.
clinically
approved
drug
nirmatrelvir
and
clinical
candidate
ensitrelvir
have
so
far
showed
great
potential
treatment
infection.
However,
broad
use
antivirals
often
associated
with
resistance
generation.
Herein,
we
enzymatically
characterized
14
naturally
occurring
Mpro
polymorphisms
that
are
close
to
binding
site
these
Nirmatrelvir
retained
its
potency
against
most
tested,
while
mutants
G143S
Q189K
were
diminished
inhibition
constants.
For
ensitrelvir,
constants
observed
M49I,
G143S,
R188S,
but
not
Q189K,
suggesting
a
distinct
profile
between
inhibitors.
In
addition,
crystal
structures
selected
revealed
interactions
critical
loss
potency.
conclusion,
our
data
will
assist
monitoring
resistant
strains,
support
design
combined
therapy,
as
well
development
next
generation
Pharmacological Reports,
Journal Year:
2022,
Volume and Issue:
74(6), P. 1255 - 1278
Published: July 25, 2022
The
use
of
antiviral
COVID-19
medications
can
successfully
inhibit
SARS-CoV-2
replication
and
prevent
disease
progression
to
a
more
severe
form.
However,
the
timing
treatment
plays
crucial
role
in
this
regard.
Oral
drugs
provide
an
opportunity
manage
infection
without
need
for
hospital
admission,
easing
general
burden
that
have
on
healthcare
system.
This
review
paper
(i)
presents
potential
pharmaceutical
targets,
including
various
host-based
targets
viral-based
(ii)
characterizes
first-generation
anti-SARS-CoV-2
oral
(nirmatrelvir/ritonavir
molnupiravir),
(iii)
summarizes
clinical
progress
other
antivirals
COVID-19,
(iv)
discusses
ethical
issues
such
trials
(v)
challenges
associated
with
practice.
represent
part
strategy
adapt
long-term
co-existence
manner
prevents
from
being
overwhelmed.
It
is
pivotal
ensure
equal
fair
global
access
currently
available
those
authorized
future.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 2, 2022
Purpose:
Michael
receptor
molecules
derived
from
plants
are
biologically
active
due
to
electrophilic
groups
in
their
structure.
They
can
target
nucleophilic
residues
on
disease-related
proteins,
with
significant
therapeutic
effects
and
low
toxicity
for
many
diseases.
provide
a
good
option
relevant
disease
treatment.
The
aim
of
this
study
is
summarize
the
existing
MAMs
applications,
lay
foundation
application
life
science
future.
Methods:
This
review
summarizes
published
studies
isolated
literature
databases
such
as
CNKI,
Wanfang
Data,
PubMed,
Web
Science,
ScienceDirect,
Wiley.
Latin
names
were
verified
through
https://www.iplant.cn/
.
All
compound
structures
PubChem
literature,
illustrated
ChemDraw
20.0.
Result:
A
total
50
various
discussed.
It
was
found
that
these
compounds
have
similar
pharmacological
potential,
most
them
play
role
Keap1-Nrf2-ARE
pathway
NF-κB
pathway,
biological
activities
antioxidant
anti-inflammatory.
be
used
treat
inflammatory
diseases
tumors.
Conclusion:
molecule
has
electrophilicity
its
unsaturated
aldehyde
ketone
structure,
which
combine
protein
form
complexes
activate
or
inhibit
physiological
role.
regulate
pathway.
inflammation,
cancer,
oxidative
stress,
etc.
Cells,
Journal Year:
2024,
Volume and Issue:
13(2), P. 123 - 123
Published: Jan. 9, 2024
The
COVID-19
pandemic
has
brought
to
the
forefront
intricate
relationship
between
SARS-CoV-2
and
its
impact
on
neurological
complications,
including
potential
links
neurodegenerative
processes,
characterized
by
a
dysfunction
of
protein
quality
control
systems
ER
stress.
This
review
article
explores
role
systems,
such
as
Unfolded
Protein
Response
(UPR),
Endoplasmic
Reticulum-Associated
Degradation
(ERAD),
Ubiquitin–Proteasome
System
(UPS),
autophagy
molecular
chaperones,
in
infection.
Our
hypothesis
suggests
that
produces
stress
exploits
leading
disruption
proteostasis
cannot
be
solved
host
cell.
culminates
cell
death
may
represent
link
neurodegeneration.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(7), P. 797 - 797
Published: July 4, 2024
The
main
protease
(Mpro)
of
SARS-CoV-2
is
an
essential
enzyme
that
plays
a
critical
part
in
the
virus’s
life
cycle,
making
it
significant
target
for
developing
antiviral
drugs.
inhibition
Mpro
has
emerged
as
promising
approach
therapeutic
agents
to
treat
COVID-19.
This
review
explores
structure
protein
and
analyzes
progress
made
understanding
protein–ligand
interactions
inhibitors.
It
focuses
on
binding
kinetics,
origin,
chemical
these
provides
in-depth
analysis
recent
clinical
trials
involving
covalent
non-covalent
inhibitors
emerging
dual
targeting
Mpro.
By
integrating
findings
from
literature
ongoing
trials,
this
captures
current
state
research
into
inhibitors,
offering
comprehensive
challenges
directions
their
future
development
anti-coronavirus
agents.
information
new
insights
inspiration
medicinal
chemists,
paving
way
more
effective
novel
COVID-19
therapies.
Viruses,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1991 - 1991
Published: Sept. 8, 2022
Coronavirus
disease
2019
(COVID-19)
has
caused
an
unprecedented
global
crisis
and
continues
to
threaten
public
health.
The
etiological
agent
of
this
devastating
pandemic
outbreak
is
the
severe
acute
respiratory
syndrome-coronavirus-2
(SARS-CoV-2).
COVID-19
characterized
by
delayed
immune
responses,
followed
exaggerated
inflammatory
responses.
It
well-established
that
interferon
(IFN)
JAK/STAT
signaling
pathways
constitute
first
line
defense
against
viral
bacterial
infections.
To
achieve
replication,
numerous
viruses
are
able
antagonize
or
hijack
these
attain
productive
infection,
including
SARS-CoV-2.
Multiple
studies
document
roles
several
non-structural
proteins
(NSPs)
SARS-CoV-2
facilitate
establishment
replication
in
host
cells
via
escape.
In
review,
we
summarize
highlight
functions
characteristics
NSPs
confer
evasion.
molecular
mechanisms
mediating
evasion
related
potential
therapeutic
strategies
for
controlling
also
discussed.
