Emerging Role of Folate-Mediated One Carbon Metabolism in Leukemia: A Review DOI Creative Commons
Jinan Thabit,

Anwar Almzaiel

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, Journal Year: 2023, Volume and Issue: 15(2), P. 215 - 229

Published: Sept. 5, 2023

Folic acid, Red blood cells (RBCs), White (WBCs) and platelets (PLTs).Leukemia is a type of cancer that develops in the bone marrow cells.When DNA cell undergoes one mutation or series mutations results formation leukemia cells.These cells, "blasts," cannot mature into fully functioning WBCs.Leukemia increases WBCs which compete for space with RBCs body requires to function normally; each may be classified as acute chronic, myeloid lymphoid, depending on originating growth rate.Nearly 2.5% all new cases 3.1% cancer-related deaths were attributable Leukemia.Leukemia can strike at any age geographical ethnic differences rates are also present.Folate's significance was exclusively tied antifolate-based treatment.After discovering Antifolate associated based chemotherapy, contrary inhibitory action antifolate tumors, epidemiologic, clinical, experimental data show folate deficiency normal tissues predispose them neoplastic transformation supplementation suppress development tumors tissues.Epidemiologic research reveals negative connection between levels numerous cancers, including Leukemia.The exact association status certain cancers unknown.Vitamin B control one-carbon metabolism human health.Folatemediated carbon (1C) supports processes essential cell.Through number interlinked reactions happening cytosol mitochondria cell, contributes de novo purine thymidylate synthesis, methionine cycle redox defense.Targeting gave rise modern chemotherapy.The cycles complete route vitamin B9 folate.Vitamin B6 regulates cycling.Vitamin dysregulation alters biochemical signaling causes several illnesses.

Language: Английский

Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging DOI
Domenico Lapenna

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102066 - 102066

Published: Sept. 7, 2023

Language: Английский

Citations

80
Crosstalk between metabolism and epigenetics during macrophage polarization DOI Creative Commons
Kangling Zhang, Chinnaswamy Jagannath

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 29, 2025

Macrophage polarization is a dynamic process driven by complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated pathogens. Upon encountering specific environmental cues, monocytes differentiate into macrophages, adopting either pro-inflammatory (M1) or anti-inflammatory (M2) phenotype, depending on the cytokines present. M1 macrophages are induced interferon-gamma (IFN-γ) characterized their reliance glycolysis role in host defense. In contrast, M2 stimulated interleukin-4 (IL-4) interleukin-13 (IL-13), favor oxidative phosphorylation participate tissue repair responses. Metabolism tightly linked to regulation, because key metabolic intermediates such as acetyl-coenzyme A (CoA), α-ketoglutarate (α-KG), S-adenosylmethionine (SAM), nicotinamide adenine dinucleotide (NAD+) serve cofactors for chromatin-modifying enzymes, which turn, directly influences histone acetylation, methylation, RNA/DNA protein arginine methylation. These control gene expression regulating chromatin accessibility, thereby modulating macrophage function polarization. Histone acetylation generally promotes more open structure conducive activation, while methylation can activate repress residue its state. Crosstalk between modifications, further fine-tunes phenotypes transcriptional networks response cues. While primarily functions epigenetics through degradation methylated proteins releases derivatives like asymmetric dimethylarginine (ADMA), contribute metabolism-a factor This review explores intricate relationships metabolism regulation during better understanding this crosstalk will likely generate novel therapeutic insights manipulating infections tuberculosis inflammatory diseases diabetes.

Language: Английский

Citations

5
Regulation of and challenges in targeting NAD+ metabolism DOI
Marie E. Migaud, Mathias Ziegler, Joseph A. Baur

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(10), P. 822 - 840

Published: July 18, 2024

Language: Английский

Citations

18
Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research DOI Creative Commons
Michael Colwell, Hosana Tagomori, Sarah Chapman

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 17, 2022

Abstract Impaired cognition is often overlooked in the clinical management of depression, despite its association with poor psychosocial functioning and reduced engagement. There an outstanding need for new treatments to address this unmet need, highlighted by our consultations individuals lived experience depression. Here we consider evidence support different pharmacological approaches treatment impaired including that influence primary neurotransmission directly as well novel targets such neurosteroid modulation. We also potential methodological challenges establishing a strong base area, disentangle direct effects on from more generalised symptomatic improvement identification sensitive, reliable objective measures cognition.

Language: Английский

Citations

33
Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma DOI Creative Commons
Xing Jin, Lei Liu, Dan Liu

et al.

Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: 31(5), P. 558 - 573

Published: April 3, 2024

Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in and reversely associated patient survival. cells readily harness exogenous to generate S-adenosyl-methionine (SAM), thus promoting proliferation. Mechanistically, augments METTL3-mediated RNA m

Language: Английский

Citations

8
Mechanisms and rationales of SAM homeostasis DOI

Xing Zheng,

Benjamin P. Tu

Trends in Biochemical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis DOI

Nahathai Limveeraprajak,

Sirapop Nakhawatchana,

Apidsada Visukamol

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 132, P. 110985 - 110985

Published: Feb. 27, 2024

Language: Английский

Citations

6
Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota DOI Open Access
Sanjay Basak, Rahul Mallick,

Boga Navya Sree

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1860 - 1860

Published: June 13, 2024

Evidence is emerging on the role of maternal diet, gut microbiota, and other lifestyle factors in establishing lifelong health disease, which are determined by transgenerationally inherited epigenetic modifications. Understanding mechanisms may help identify novel biomarkers for gestation-related exposure, burden, or disease risk. Such essential developing tools early detection risk exposure levels. It necessary to establish an threshold due nutrient deficiencies environmental that can result clinically relevant alterations modulate risks fetus. This narrative review summarizes latest updates roles nutrients (n-3 fatty acids, polyphenols, vitamins) microbiota placental epigenome its impacts fetal brain development. unravels potential functional targeted intervention ensure optimal development performance later life.

Language: Английский

Citations

5
Unraveling the metabolic‒epigenetic nexus: a new frontier in cardiovascular disease treatment DOI Creative Commons
Jun Ouyang, Dong-de Wu,

Y. Gan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

Abstract Cardiovascular diseases are the leading causes of death worldwide. However, there still shortcomings in currently employed treatment methods for these diseases. Therefore, exploring molecular mechanisms underlying cardiovascular is an important avenue developing new strategies. Previous studies have confirmed that metabolic and epigenetic alterations often involved across patients. Moreover, factors interact with each other affect progression a coordinated manner. Lactylation novel posttranslational modification (PTM) links metabolism epigenetics affects disease progression. analyzing crosstalk between cellular expected to provide insights development The purpose this review describe relationship heart such as failure, myocardial infarction, atherosclerosis, focus on acylation methylation, propose potential therapeutic measures.

Language: Английский

Citations

0
Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation DOI Creative Commons
Sherif Rashad, Aseel Marahleh

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2025, Volume and Issue: 16(2)

Published: March 1, 2025

ABSTRACT Transfer RNA (tRNA) is not merely a passive carrier of amino acids, but an active regulator mRNA translation controlling codon bias and optimality. The synthesis various tRNA modifications regulated by many “writer” enzymes, which utilize substrates from metabolic pathways or dietary sources. Metabolic bioenergetic pathways, such as one‐carbon (1C) metabolism the tricarboxylic acid (TCA) cycle produce essential for synthesis, S‐Adenosyl methionine (SAM), sulfur species, α‐ketoglutarate (α‐KG). activity these can directly impact decoding via regulating levels. In this review, we discuss complex interactions between diet, metabolism, modifications, translation. We how nutrient availability, bioenergetics, intermediates modulate modification landscape to fine‐tune protein synthesis. Moreover, highlight dysregulation metabolic‐tRNA contributes disease pathogenesis, including cancer, disorders, neurodegenerative diseases. also new emerging field GlycoRNA biology drawing parallels glycobiology diseases guide future directions in area. Throughout our discussion, links specific their metabolic/dietary precursors, diseases, emphasizing importance metabolism‐centric view understanding pathologies. Future research should focus on uncovering interplay cellular contexts. Addressing gaps will into novel interventions.

Language: Английский

Citations

0