The host genotype actively shapes its microbiome across generations in laboratory mice DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 5, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected two-cell stage embryos from representative wild types, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. Graphical

Language: Английский

Functionally enriched human polymorphisms associate to species in the chronic wound microbiome DOI
Rebecca Gabrilska,

Khalid Omeir,

Jacob Ancira

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

ABSTRACT Chronic wounds are a burden to millions of patients and healthcare providers worldwide. With rising incidence prevalence, there is an urgent need address non-healing with novel approaches. Impaired wound healing has been shown be associated microbiota, multiple bacterial species known contribute delays in closure. Recent evidence suggests human genetics may shape differences composition microbiomes, unraveling this relationship important implications for understanding bioburden tailoring treatment. Here, two-stage microbiome genome wide association study (mbGWAS; n=509) was used test effects on the relative abundances detected chronic using 16S rRNA gene sequencing. Sixteen were significantly 193 genetic loci distributed across 25 non-overlapping genomic regions. No locus more than one species, heritability estimates per ranging up 20%. Functional analyses regions resulted overrepresentation pertaining pathways relevant microbial infection healing, suggesting that interactions jointly influence microenvironment. Species host turn exhibited significant co-occurrence relationships common pathogens including Staphylococcus aureus Finegoldia magna . Moreover, overall distance among related their composition. Identification such biomarkers reveals new mechanistic insight into patient-microbiome provides avenue identify predictive risk factors diagnosis management wounds.

Language: Английский

Citations

0
The role of yes‐associated protein in nasal inflammatory diseases DOI Creative Commons
Bing Zhong, Yu Zhao

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract Yes‐associated protein (YAP), a pivotal of the Hippo signaling pathway, plays crucial role in regulating cell proliferation and differentiation. Emerging evidence highlights its significance respiratory inflammatory disorders, including chronic rhinosinusitis, allergic rhinitis. This review delves into impact YAP on individuals affected by these ailments, with specific focus it nasal mucosal epithelial cells. We further explore interplay between mediators, outlining pathological mechanisms through which contributes to tissue restructuring contexts. Despite advancements, gaps persist understanding YAP's broader clinical applications. Future research directions are proposed this article bridge knowledge gaps.

Language: Английский

Citations

0
The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer DOI Creative Commons
Bing Zhong, Jintao Du,

Feng Liu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Yes-associated protein (YAP) plays a central role in the Hippo pathway, primarily governing cell proliferation, differentiation, and apoptosis. Its significance extends to tumorigenesis inflammatory conditions, impacting disease initiation progression. Given increasing relevance of YAP disorders cancer, this study aims elucidate its pathological regulatory functions these contexts. Specifically, we aim investigate involvement molecular mechanisms various diseases cancers. We particularly focus on how activation, whether through Hippo-dependent or independent pathways, triggers release inflammation mediators respiratory, cardiovascular, digestive conditions. In not only promotes tumor proliferation differentiation but also modulates immune microenvironment, thereby fostering metastasis Additionally, provide an overview current YAP-targeted therapies. By emphasizing YAP's enhance our understanding protein's pivotal processes, intricate related diseases, contribute future drug development strategies targeting YAP.

Language: Английский

Citations

0
Upper respiratory microbial communities of healthy populations are shaped by niche and age DOI Creative Commons
Susan Zelasko, Mary Hannah Swaney, Shelby Sandstrom

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 14, 2024

Alterations in upper respiratory microbiomes have been implicated shaping host health trajectories, including by limiting mucosal pathogen colonization. However, limited comparative studies of microbiome development and functioning across age groups performed. Herein, we perform shotgun metagenomic sequencing paired with inhibition assays to elucidate differences nasal oral composition healthy 24-month-old infant (n=229) adult (n=100) populations.

Language: Английский

Citations

1
Yokenella regensburgei—Past, Present and Future DOI Creative Commons
Dan Alexandru Țoc, Carmen Costache, Vlad Sever Neculicioiu

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 589 - 589

Published: June 26, 2024

is a Gram-negative rod part of the

Language: Английский

Citations

1
Nasal microbiome dynamics: decoding the intricate nexus in the progression of respiratory and neurological diseases DOI

Keerti Maheshwari,

R. Gupta, Ruchika Sharma

et al.

Critical Reviews in Microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Aug. 19, 2024

In recent times, the nasal region has emerged as a distinctive and dynamic environment where myriad of microbial communities establish residence from infancy, persisting both commensal opportunistic pathogens throughout lifespan. Understanding coexistence microorganisms in respiratory mucosal layers, their potential for infections, underlying molecular mechanisms shaping these interactions is crucial developing efficient diagnostic therapeutic interventions against neurodegenerative diseases. Despite significant strides understanding olfactory system's nexus with microbiota, comprehensive correlations neurological diseases still need to be discovered. The microbiome, sentinel immune defense, orchestrates delicate equilibrium that, when disrupted, can precipitate severe including Chronic Rhinosinusitis, obstructive pulmonary disorder (COPD), Asthma, instigate cascade effect on central nervous system such Alzheimer's disease (AD), Parkinson's (PD), Multiple sclerosis (MS). This review aims redress this imbalance by meticulously exploring anatomical microbiological nuances surface health disease. By delineating intricacies interactions, unravels that govern intricate between microbiota dysbiosis, dysfunction, progression

Language: Английский

Citations

1
Upper respiratory microbial communities of healthy populations are shaped by niche and age DOI Creative Commons
Susan Zelasko, Mary Hannah Swaney, Shelby Sandstrom

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 18, 2024

Alterations in upper respiratory microbiomes have been implicated shaping host health trajectories, including by limiting mucosal pathogen colonization. However, limited comparative studies of microbiome development and functioning across age groups performed. Herein, we perform shotgun metagenomic sequencing paired with inhibition assays to elucidate differences nasal oral composition intermicrobial interactions healthy 24-month-old infant (n = 229) adult 100) populations. We find that beta diversity varies age, showing greater population-level variation compared microbiomes. Infant alpha was significantly lower samples higher samples, relative adults. Accordingly, demonstrate significant genus- species-level between sites groups. Antimicrobial resistome patterns likewise varied body sites, resistance gene abundance Biosynthetic clusters encoding specialized metabolite production were found microbiomes, Investigation revealed gram-negative gram-positive bacteria commensals, while isolates had antifungal activity. In summary, identify the microbial communities inhabiting cavities infants These findings inform our understanding impacting functions related colonization resistance, important implications for lifespan.

Language: Английский

Citations

1
The host genotype actively shapes its microbiome across generations DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected 2-cell stage embryos from representative wildtypes, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. graphical abstract

Language: Английский

Citations

0
Impact of microplastics, fluoride, and mancozeb on tomato plant growth and rhizosphere microbial dynamics: A metagenomic analysis DOI
Ajay Kumar, Rajni Sharma,

Muskan Bokolia

et al.

Pedosphere, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0
The host genotype actively shapes its microbiome across generations in laboratory mice DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 5, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected two-cell stage embryos from representative wild types, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. Graphical

Language: Английский

Citations

0