Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1087 - 1087
Published: Nov. 14, 2024
Antimicrobial
resistance
(AMR)
is
a
serious
global
health
issue,
aggravated
by
antibiotic
overuse
and
misuse
in
human
medicine,
animal
care,
agriculture.
This
study
looks
at
the
different
mechanisms
that
drive
AMR,
such
as
environmental
contamination,
horizontal
gene
transfer,
selective
pressure,
well
severe
implications
of
AMR
for
health.
demonstrates
need
concerted
efforts
across
scientific,
healthcare,
agricultural,
policy
sectors
to
control
emergence
AMR.
Some
crucial
strategies
discussed
include
developing
antimicrobial
stewardship
(AMS)
programs,
encouraging
targeted
narrow-spectrum
use,
emphasizing
significance
strict
regulatory
frameworks
surveillance
systems,
like
Global
Resistance
Use
Surveillance
System
(GLASS)
Access,
Watch,
Reserve
(AWaRe)
classification.
also
emphasizes
national
international
action
plans
combating
promotes
One
Health
strategy,
which
unifies
environmental,
animal,
concludes
preventing
spread
maintaining
effectiveness
antibiotics
future
generations
requires
comprehensive,
multidisciplinary,
internationally
coordinated
strategy.
mSphere,
Journal Year:
2024,
Volume and Issue:
9(2)
Published: Feb. 7, 2024
River
microbial
communities
regularly
act
as
the
first
barrier
of
defense
against
spread
antimicrobial
resistance
genes
(ARGs)
that
enter
environmental
microbiomes
through
wastewater.
However,
how
invasion
dynamics
wastewater-borne
ARGs
into
river
biofilm
will
shift
due
to
climate
change
with
increasing
average
and
peak
temperatures
remains
unknown.
Here,
we
aimed
elucidate
effects
on
naturally
occurring
resistome,
well
success
foreign
entering
Natural
biofilms
were
grown
in
a
low-anthropogenic
impact
transferred
artificial
laboratory
recirculation
flume
systems
operated
at
three
different
(20°C,
25°C,
30°C).
After
1
week
temperature
acclimatization,
significant
increases
abundance
detected
higher
temperatures.
this
acclimatization
period,
exposed
single
pulse
wastewater,
analyzed
over
2
weeks.
day,
able
invade
successfully
no
observable
effect
their
relative
abundance.
thereafter,
lost
far
increased
rate
30°C,
ARG
levels
dropping
initial
natural
after
14
days.
Contrary
lower
temperatures,
either
slower
rates
or
even
establish
themselves
stable
abundances
above
levels.
Hence,
come
contrary
resistomes:
increase
abundance,
while
foreign,
invading
are
elevated
speeds.IMPORTANCEInfections
bacteria
gained
antibiotics
taking
millions
lives
annually,
death
toll
predicted
increase.
environment
wastewater
enrichment
human
animal
microbiomes.
The
global
might
disrupt
by
altering
community
structure
functions.
We
consequently
explored
alter
communities.
At
coincided
decreased
from
Therefore,
predict
microbiomes,
it
is
imperative
consider
if
ecosystem
its
resistome
dominated
ARGs.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(10), P. 941 - 941
Published: Oct. 6, 2024
Microplastic
aging
affects
the
dynamics
of
antibiotic
resistance
genes
(ARGs)
on
microplastics,
yet
no
review
presents
effects
microplastic
associated
ARGs.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 18, 2025
Environmental
surveillance
of
antibiotic
resistance
genes
(ARGs)
is
critical
for
understanding
and
mitigating
the
spread
antimicrobial
resistance.
Current
short-read-based
ARG
profiling
methods
are
limited
in
their
ability
to
provide
detailed
host
information,
which
indispensable
tracking
transmission
assessing
risk
ARGs.
Here,
we
present
Argo,
a
novel
approach
that
leverages
long-read
overlapping
rapidly
identify
quantify
ARGs
complex
environmental
metagenomes
at
species
level.
Argo
significantly
enhances
resolution
detection
by
assigning
taxonomic
labels
collectively
clusters
reads,
rather
than
individual
reads.
By
benchmarking
performance
identification
using
simulation,
confirm
advantage
over
existing
metagenomic
strategies
terms
accuracy.
Using
sequenced
mock
communities
with
varying
quality
scores
read
lengths,
along
global
fecal
dataset
comprising
329
human
non-human
primate
samples,
demonstrate
Argo's
capability
deliver
comprehensive
species-resolved
profiles
real
settings.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3174 - 3174
Published: March 29, 2025
In
recent
years,
the
interest
in
developing
genetically
modified
microorganisms
(GMMs),
including
GMMs
developed
by
genome
editing,
for
use
environment
has
significantly
increased.
However,
scientific
knowledge
on
ecology
of
such
is
severely
limited.
There
also
little
experience
at
hands
regulators
how
to
evaluate
environmental
safety
and
assess
whether
they
provide
sustainable
alternatives
current
(agricultural)
production
systems.
This
review
analyzes
two
different
GMM
applications,
GM
microalgae
biofuel
nitrogen-fixing
soil
bacteria
as
biofertilizers.
We
challenges
posed
regulatory
risk
assessment
(ERA)
against
background
GMO
legislation
existing
European
Union
(EU).
Based
our
analysis,
we
present
recommendations
ERA
monitoring
particular
improvement
EU
guidance.
explore
approaches
technology
can
a
framework
broader
applications.
To
this
end,
recommend
implementing
an
evidence-based
sustainability
analysis
other
methods
support
decision
making
address
societal
concerns
linked
applications
environment.
