International Journal of Infectious Diseases,
Journal Year:
2022,
Volume and Issue:
122, P. 30 - 32
Published: May 13, 2022
To
explore
a
potential
country-based
ecological
link
between
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
Omicron
variant
(B.1.1.529)
infection
and
an
apparent
current
global
outbreak
of
hepatitis
unknown
etiology
among
children.We
examined
country-level
statistical
associations
reported
detection
one
or
more
unexplained
cases
in
children
the
cumulative
number
38
Organisation
for
Economic
Co-operation
Development
(OECD)
member
countries
plus
Romania.At
least
focal
case
was
detected
12
39
included
our
analysis.
Numbers
confirmed
these
ranged
from
4.4
to
11.9
million.
Among
remaining
27
countries,
this
measure
0.5
5.5
million
cases.
Countries
which
experienced
higher
precedent
population
burdens
relative
those
did
not
report
any
such
(p=0.013).Prior
exposure
may
be
associated
with
increased
risk
children,
indicating
critical
need
conduct
cofactor
studies.
Clinical Infectious Diseases,
Journal Year:
2022,
Volume and Issue:
76(3), P. e179 - e187
Published: July 9, 2022
Secondary
sclerosing
cholangitis
(SSC)
is
a
rare
disease
with
poor
prognosis.
Cases
of
SSC
have
been
reported
following
coronavirus
2019
(COVID-SSC).
The
aim
this
study
was
to
compare
COVID-SSC
in
critically
ill
patients
(SSC-CIP)
and
assess
factors
influencing
transplant-free
survival.In
retrospective,
multicenter
involving
127
from
9
tertiary
care
centers
Germany,
compared
SSC-CIP
logistic
regression
analyses
were
performed
investigating
impacting
survival.Twenty-four
had
COVID-SSC,
77
SSC-CIP,
26
other
forms
SSC.
developed
after
median
91
days
COVID-19
diagnosis.
All
received
extensive
intensive
treatment
(median
mechanical
ventilation,
48).
Patients
comparable
most
the
clinical
parameters
survival
not
different
(P
=
.443,
log-rank
test).
In
overall
cohort,
use
ursodeoxycholic
acid
(UDCA)
(odds
ratio
[OR],
0.36
[95%
confidence
interval
{CI},
.16-.80],
P
.013;
<
.001)
high
serum
albumin
levels
(OR,
0.40
CI,
.17-.96],
.040)
independently
associated
an
increased
survival,
while
presence
liver
cirrhosis
2.52
1.01-6.25],
.047)
worse
outcome.
Multidrug-resistant
organism
(MDRO)
colonization
or
infection
did
impact
patients'
survival.COVID-SSC
CIP-SSC
share
same
phenotype,
course
disease,
risk
for
its
development.
UDCA
may
be
promising
therapeutic
option
SSC,
though
future
prospective
trials
are
needed
confirm
our
findings.
World Journal of Gastroenterology,
Journal Year:
2023,
Volume and Issue:
29(2), P. 257 - 271
Published: Jan. 5, 2023
The
new
coronavirus
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
was
identified
in
December
2019,
Wuhan,
China.
virus
rapidly
spread
worldwide,
causing
disease
2019
(COVID-19)
pandemic.
Although
COVID-19
is
presented,
usually,
with
typical
symptoms
(i.e.,
dyspnea,
cough)
and
fever,
extrapulmonary
manifestations
are
also
encountered.
Liver
injury
a
common
feature
patients
ranges
from
mild
temporary
elevation
of
liver
enzymes
to
and,
even,
failure.
pathogenesis
damage
not
clearly
defined;
multiple
mechanisms
contribute
disorder,
including
direct
cytopathic
viral
effect,
cytokine
storm
immune-mediated
hepatitis,
hypoxic
injury,
drug-induced
toxicity.
Patients
underlying
chronic
cirrhosis,
non-alcoholic
fatty
disease,
alcohol-related
hepatocellular
carcinoma,
etc.)
may
have
greater
risk
develop
both
further
deterioration,
as
consequence,
certain
issues
should
be
considered
during
management.
aim
this
review
present
the
prevalence,
clinical
manifestation
pathophysiological
SARS-CoV-2
infection.
Moreover,
we
overview
association
between
infection
briefly
discuss
management
COVID-19.
Clinical and Molecular Hepatology,
Journal Year:
2024,
Volume and Issue:
30(4), P. 943 - 958
Published: Aug. 29, 2024
Background/Aims:
Considering
emerging
evidence
on
long
COVID,
comprehensive
analyses
of
the
post-acute
complications
SARS-CoV-2
infection
in
gastrointestinal
and
hepatobiliary
systems
are
needed.
We
aimed
to
investigate
impact
COVID-19
long-term
risk
diseases
other
digestive
abnormalities.Methods:
used
three
large-scale
population-based
cohorts:
Korean
cohort
(discovery
cohort),
Japanese
(validation
cohort-A),
UK
Biobank
cohort-B).
A
total
10,027,506
Korean,
12,218,680
Japanese,
468,617
patients
aged
≥20
years
who
had
between
2020
2021
were
matched
non-infected
controls.
Seventeen
eight
outcomes
as
well
nine
abnormalities
following
identified
compared
with
controls.Results:
The
discovery
revealed
heightened
risks
(HR
1.15;
95%
CI
1.08–1.22),
1.30;
1.09–1.55),
1.05;
1.01–1.10)
beyond
first
30
days
infection,
after
exposure-driven
propensity
score-matching.
was
pronounced
according
severity.
vaccination
found
lower
but
did
not
affect
disorders.
results
derived
from
validation
cohorts
consistent.
profile
most
during
initial
3
months;
however,
it
persisted
for
>6
months
cohorts,
cohort.Conclusions:
incidence
disease,
increased
phase.
International Journal of Infectious Diseases,
Journal Year:
2022,
Volume and Issue:
122, P. 30 - 32
Published: May 13, 2022
To
explore
a
potential
country-based
ecological
link
between
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
Omicron
variant
(B.1.1.529)
infection
and
an
apparent
current
global
outbreak
of
hepatitis
unknown
etiology
among
children.We
examined
country-level
statistical
associations
reported
detection
one
or
more
unexplained
cases
in
children
the
cumulative
number
38
Organisation
for
Economic
Co-operation
Development
(OECD)
member
countries
plus
Romania.At
least
focal
case
was
detected
12
39
included
our
analysis.
Numbers
confirmed
these
ranged
from
4.4
to
11.9
million.
Among
remaining
27
countries,
this
measure
0.5
5.5
million
cases.
Countries
which
experienced
higher
precedent
population
burdens
relative
those
did
not
report
any
such
(p=0.013).Prior
exposure
may
be
associated
with
increased
risk
children,
indicating
critical
need
conduct
cofactor
studies.
