Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns DOI Creative Commons
Bárbara Costa, Maria João Gouveia, Nuno Vale

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1518 - 1518

Published: Dec. 12, 2024

Oxidative stress plays a critical role in various physiological and pathological processes, particularly during pregnancy, where it can significantly affect maternal fetal health. In the context of viral infections, such as those caused by Human Immunodeficiency Virus (HIV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxidative may exacerbate complications disrupting cellular function immune responses. Antiviral drugs, while essential managing these also contribute to stress, potentially impacting both mother developing fetus. Understanding mechanisms which antivirals examination pharmacokinetic changes pregnancy that influence drug metabolism is essential. Some research indicates antiretroviral drugs induce mitochondrial dysfunction other studies suggest their use generally safe. Therefore, concerns about long-term health effects persist. This review delves into complex interplay between antioxidant defenses, antiviral therapies, focusing on strategies mitigate potential damage. By addressing gaps our understanding, we highlight importance balancing efficacy with risks stress. Moreover, advocate for further develop safer, more effective therapeutic approaches pregnancy. dynamics optimizing outcomes fetus infections

Language: Английский

Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches DOI Creative Commons
Tihamér Molnár,

Andrea Lehoczki,

Mónika Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 5267 - 5286

Published: April 26, 2024

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced medical community to phenomenon of long COVID, a condition characterized persistent symptoms following resolution acute phase infection. Among myriad reported COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond initial viral pathology. Emerging evidence pointed mitochondrial dysfunction as potential underpinning mechanism contributing persistence diversity symptoms. This review aims synthesize current findings related in exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic endothelial dysfunction. Through comprehensive analysis literature, we highlight significance health pathophysiology drawing parallels with similar clinical syndromes linked post-infectious states other diseases where impairment been implicated. We discuss therapeutic strategies targeting function, including pharmacological interventions, lifestyle modifications, exercise, dietary approaches, emphasize need further research collaborative efforts advance our understanding management COVID. underscores critical role calls multidisciplinary approach address gaps knowledge treatment options those affected this condition.

Language: Английский

Citations

30
Intranasal liposomal remdesivir induces SARS-CoV-2 clearance in K18-hACE2 mice and ensures survival DOI
Sabrina Mendes, Lays Cordeiro Guimarães, Leonardo Camilo de Oliveira

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 558 - 573

Published: Jan. 24, 2025

Language: Английский

Citations

1
Drug Induced Liver Injury: Highlights and Controversies in the 2023 Literature DOI
Harjit Singh, Bryce Kunkle,

Angela Troia

et al.

Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

1
Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis DOI Creative Commons

Kunwadee Noonong,

Moragot Chatatikun, Sirirat Surinkaew

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

Significance This review discusses the coronavirus disease 2019 (COVID-19) pathophysiology in context of diabetes and intracellular reactions by COVID-19, including mitochondrial oxidative stress storms, ROS long COVID. Recent advances The COVID is suffered ~10% COVID-19 patients. Even virus does not exist, patients suffer for even over a year, could be mitochondria dysregulation disease. Critical issues Patients who recover from can develop new or persistent symptoms multi-organ complications lasting weeks months, called underlying mechanisms involved still unclear. Once persist, they cause significant damage, leading to numerous, symptoms. Future directions A comprehensive map stages pathogenetic related effective drugs treat prevent it are required, which will aid development future treatments symptom relief.

Language: Английский

Citations

18
Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects DOI Creative Commons
Catarina Marques, Lia‐Tânia Dinis, Maria João Santos

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(23), P. 4277 - 4277

Published: Nov. 27, 2023

Health-promoting compounds in wine and wine-related products are important due to their potential benefits human health. Through an extensive literature review, this study explores the presence of these products, examining relationship with terroir impact on aromatic flavor properties that perceived orally: sunlight exposure, rainfall patterns, soil composition grapevines’ synthesis accumulation health-promoting compounds. Enzymes, pH, oral microbiome crucial sensory evaluation perception health promotion. Moreover, analysis relies considerations such as specific target compound, selectivity, sensitivity, complexity matrix.

Language: Английский

Citations

11
Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS‐CoV‐2 Infection: A Descriptive Study DOI Open Access
Shuxia Wang,

Jin Sun,

Yazhuo Hu

et al.

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT This study aims to identify the risk factors associated with clinical outcomes and proteomic changes in organs related fatal SARS‐CoV‐2 infection within super‐elderly population. retrospective analysis included all elderly individuals COVID‐19 admitted Second Medical Center of PLA General Hospital from December 2022 January 2023. The follow‐up period ended on March 30, During this time, epidemiological, demographic, laboratory, outcome data were analyzed descriptively. Proteomic sequencing was performed patients who died at different stages disease. A total 352 patients, a mean age 89.84 ± 8.54 years, study. median 98 days, 79 died. Deceased older more likely have cardiovascular cerebrovascular diseases, lower prevalence lipid‐lowering therapy. number deaths acute post‐acute phases 34 45, respectively. Proteomics suggest that immune systems phase underwent rapid severe onslaught. Patients showed higher levels viral genome replication robust response. However, over‐activation system led systemic organ dysfunction. Effective management comorbidities may improve prognosis patients. continuous virus its subsequent impact are critical determinants survival time demographic.

Language: Английский

Citations

0
Mitochondrial haplogroups and variants defines differential severity of COVID-19 in the Pakistani population DOI
Ali Raza Bukhari, Yasir Rehman, Javaria Ashraf

et al.

Published: March 18, 2025

Abstract Mitochondria play a crucial role in cellular functions, including immune responses and their dysfunction is observed SARS-CoV-2-infected cells. Here we investigated mitochondrial DNA (mtDNA) variations COVID-19 severity, focusing on potential impact of variants and/or haplogroups. PCR cases (n = 147) healthy controls (HC; n 40) were recruited, mt-DNA was amplified, sequenced analyzed for haplogroups genetic variations. categorized as Critical severe (CS; 40), Moderate (MOD; 43) Asymptomatic/mild (AMD; 64) disease. Haplogroup analysis showed major haplogroup M negatively associated with CS Whereas U positive association W an increased AMD COVID-19. Furthermore, 46 significantly the identified. More importantly mt.5186A > T ND2 gene high mutpred score Overall, are its severity Pakistani population.

Language: Английский

Citations

0
Mitochondria in COVID-19: from cellular and molecular perspective DOI Creative Commons
Michał Rurek

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: June 21, 2024

The rapid development of the COVID-19 pandemic resulted in a closer analysis cell functioning during β-coronavirus infection. This review will describe evidence for as syndrome with strong, albeit still underestimated, mitochondrial component. Due to sensitivity host mitochondria coronavirus infection, SARS-CoV-2 affects signaling, modulates immune response, modifies cellular energy metabolism, induces apoptosis and ageing, worsening symptoms which can sometimes be fatal. Various aberrations across human systems tissues their relationships were reported. In this review, particular attention is given characterization multiple alterations gene expression pattern metabolism COVID-19; complexity interactions between proteins presented. participation mitogenome fragments signaling occurrence subgenomic RNA within membranous compartments, including widely discussed. As severely quality system mitochondria, background dynamics additionally characterized. Finally, perspectives on mitigation by affecting biogenesis numerous compounds therapeutic treatments are briefly outlined.

Language: Английский

Citations

3
Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19 DOI Creative Commons
Alireza FakhriRavari,

Mazyar Malakouti

Pharmacoepidemiology, Journal Year: 2024, Volume and Issue: 3(1), P. 69 - 81

Published: Feb. 13, 2024

Severe acute respiratory syndrome coronavirus 2 has infected millions of people, but about 20% individuals do not develop symptoms. COVID-19 is an inflammatory disease that affects a portion with the virus and it associated liver injury other complications, leading to hospitalization, critical illness, death. Remdesivir antiviral agent used for treatment hospitalized patients improve time recovery, reduce duration mechanical ventilation, decrease need supplemental oxygen, risk mortality. Remdesivir-associated hepatotoxicity been observed as increased transaminases more than five times upper limit normal in COVID-19, causality proven. It generally difficult distinguish between remdesivir-associated COVID-19-induced hepatotoxicity. The purpose this review evaluate evidence Current suggests elevated enzymes are likely be due infection remdesivir, 5-day course remdesivir seems safe regard

Language: Английский

Citations

2
Novel biomarkers of mitochondrial dysfunction in Long COVID patients DOI Creative Commons
Titanilla Szögi, Barbara N. Borsos,

Dejana Masic

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Coronavirus disease 2019 (COVID-19) can lead to severe acute respiratory syndrome, and while most individuals recover within weeks, approximately 30–40% experience persistent symptoms collectively known as Long COVID, post-COVID-19 or post-acute sequelae of syndrome coronavirus 2 (SARS-CoV-2) infection (PASC). These enduring symptoms, including fatigue, difficulties, body pain, short-term memory loss, concentration issues, sleep disturbances, persist for months. According recent studies, SARS-CoV-2 causes prolonged disruptions in mitochondrial function, significantly altering cellular energy metabolism. Our research employed transmission electron microscopy reveal distinct structural abnormalities COVID patients, notably significant swelling, disrupted cristae, an overall irregular morphology, which indicates distress. We noted increased levels superoxide dismutase 1 signals oxidative stress elevated autophagy-related 4B cysteine peptidase levels, indicating mitophagy. Importantly, our analysis also identified reduced circulating cell-free DNA (ccf-mtDNA) these serving a novel biomarker the condition. findings underscore crucial role dysfunction pathogenesis COVID. Further exploration molecular mechanisms underlying post-viral is critical, particularly understand roles autoimmune reactions reactivation latent viruses perpetuating conditions. This comprehensive understanding could pave way targeted therapeutic interventions designed alleviate chronic impacts By utilizing ccf-mtDNA other biomarkers, we enhance diagnostic capabilities improve management this complex syndrome.

Language: Английский

Citations

2