Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 100043 - 100043
Published: Nov. 14, 2024
Language: Английский
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 20, 2024
Language: Английский
Citations
11
Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
1
Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Language: Английский
Citations
1
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 294 - 312
Published: Feb. 20, 2025
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 1017 - 1030
Published: Feb. 24, 2025
Hypoxia plays an important role in the progression of atherosclerosis. However, ameliorating hypoxia at atherosclerotic lesions remains a great challenge. To achieve targeted oxygen delivery to plaques, Lipid 5-doped, platelet membrane-encapsulated magnetic mesoporous organosilicon nanoparticles loaded with perfluoro-15-crown ether (PFCE) (FMMON@PL) were prepared. PFCE worked as carrier, while iron oxide (IONPs) acted nanozymes catalase-like activity facilitate generation. enhance plaque targeting, membranes coated onto containing and IONPs. 5 tertiary amine was doped into for lysosomal escape. Our results demonstrated that FMMON@PL specifically macrophages plaques. significantly reduced HIF-1α expression, ameliorated oxidative stress, inhibited foam cell formation, M1 macrophage polarization. In conclusion, successfully achieved within plaques progression, demonstrating feasibility alleviation treatment
Language: Английский
Citations
1
Current Atherosclerosis Reports, Journal Year: 2025, Volume and Issue: 27(1)
Published: April 2, 2025
Atherosclerosis is traditionally viewed as a disease triggered by lipid accumulation, but growing evidence underscores the crucial role of plaque microenvironment in progression. This review explores recent advances understanding how cellular and extracellular components milieu drive atherosclerosis, with focus on leveraging these microenvironmental factors for therapeutic intervention. highlights cell-cell crosstalk matrix remodeling, offering insights into innovative strategies atherosclerotic cardiovascular disease. While atherosclerosis begins subendothelial retention apolipoprotein B (ApoB)-containing lipoproteins, its progression increasingly recognized consequence complex dynamics within microenvironment. Soluble proteins shape mechanical properties biochemical landscape, directly influencing cell behavior inflammatory signaling. For instance, deposition transitional proteins, such fibronectin, regions disturbed flow primes endothelial cells inflammation. Likewise, impaired clearance dead chronic remodeling contribute to lesion expansion instability, further exacerbating severity. Targeting presents promising avenue stabilizing lesions. Approaches that enhance beneficial interactions, boosting macrophage efferocytosis resolve inflammation while mitigating proatherogenic signals like integrin-mediated activation, may promote fibrous cap formation reduce vulnerability. Harnessing mechanisms lead novel approaches aimed at modifying combat
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 23, 2025
Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117183 - 117183
Published: July 30, 2024
Atherosclerosis, characterized by the accumulation of plaque within arterial walls, is an intricate cardiovascular disease that often results in severe health issues. Recent studies have emphasized importance ferroptosis, a controlled type cell death dependent on iron, as critical factor this state. Ferroptosis, distinguished its reliance iron and lipid hydroperoxides, offers unique insight into pathology atherosclerotic lesions. This summary encapsulates current knowledge role ferroptosis plays onset progression atherosclerosis. It explores molecular processes through which peroxidation metabolism contribute to development atheromatous plaques evaluates possibility utilizing novel treatment approach for By illuminating relationship between ferroptosis-related atherosclerosis, review paves way future clinical applications personalized medicine approaches aimed at alleviating effects
Language: Английский
Citations
6
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Aug. 12, 2024
Cell activation and nutrient dysregulation are common consequences of atherosclerosis its preceding risk factors, such as hypertension, dyslipidemia, diabetes. These diseases may also impact cellular metabolism consequently cell function, the other way around, altered can disease development progression through function. Understanding contribution to how be by co-morbidities factors could support novel strategies lower CVD. Therefore, we briefly review pathogenesis principles metabolic pathways, before detailing changes in context comorbidities. In hypoxic, inflammatory hyperlipidemic milieu atherosclerotic plaque riddled with oxidative stress, shifts increase anaerobic glycolysis, pentose-phosphate pathway amino acid use. We elaborate on for macrophages, neutrophils, vascular endothelial cells, smooth muscle cells lymphocytes Since causal relationships specific key genes a type-specific comorbidity-dependent, cell-specific must thoroughly explored vivo , focus systemic effects. When treatments become feasible, this information will crucial determining best intervention improve interplay co-morbidities.
Language: Английский
Citations
6
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 6, 2025
Obesity is one of the major global health concerns 21st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated steatotic liver disease, and early aggressive atherosclerotic cardiovascular which leading cause death worldwide. Bile acids (BAs) incretins are gut hormones involved in digestion absorption fatty acids, insulin secretion, respectively. In recent years BAs increasingly recognized key signaling molecules, target multiple tissues organs, beyond gastro-intestinal system. Moreover, incretin-based therapy has revolutionized treatment T2DM obesity. This mini review highlights current knowledge about dysregulations BA homeostasis obesity a special focus on atherosclerosis well athero-modulating roles currently available therapies.
Language: Английский
Citations
0