The perspective of targeting cancer cell metabolism: combination therapy approaches DOI

Arezu Karimpur-zahmatkesh,

Mohammad Khalaj‐Kondori

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 9, 2025

Language: Английский

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets DOI Creative Commons
Ding Nan,

Weiping Yao,

Luanluan Huang

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Gemcitabine Alters Phosphatidylcholine Metabolism in Mouse Pancreatic Tumors DOI
Nav Raj Phulara,

Chiaki Tsuge Ishida,

Peter J. Espenshade

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest diseases, despite advancements in elucidating tumor biology and developing novel therapeutics. Importantly, lipids, such as phospholipids, are crucial for survival proliferation of cells. However, impact chemotherapeutic drugs on phospholipid metabolism PDAC remains poorly understood. Gemcitabine (a nucleoside analogue) a first-line drug treatment, but its clinical effectiveness limited by multiple factors. Herein, we employed matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) proteomics approaches to investigate gemcitabine-induced lipid alterations mouse pancreatic tumors following gemcitabine treatment (n = 3, control tumors; n gemcitabine-treated tumors). From MALDI MSI experiments, observed elevated levels several phosphatidylcholines (PCs), PC(30:0), PC(32:3), PC(34:2), PC(36:1), PC(36:2), tissues compared control. In addition, data revealed differential abundance phospholipid-binding proteins response treatments. Furthermore, endoplasmic reticulum stress-related exhibited high expression tissues. Altogether, our provide important insights into PC treatment. targeting altered during therapy might help combat cancer.

Language: Английский

Citations

0
Computational modeling of metabolism in oncology DOI
Linda Fong, Meng Jin,

Samir Kharbanda

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 81 - 107

Published: Jan. 1, 2025

Language: Английский

Citations

0
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches DOI Creative Commons

K. Linda,

Hyun Min Lee,

Yun‐Sok Ha

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115529 - 115529

Published: April 1, 2025

Language: Английский

Citations

0
The perspective of targeting cancer cell metabolism: combination therapy approaches DOI

Arezu Karimpur-zahmatkesh,

Mohammad Khalaj‐Kondori

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 9, 2025

Language: Английский

Citations

0