Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163830 - 163830
Published: May 1, 2025
Language: Английский
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 395 - 405
Published: April 5, 2024
Language: Английский
Citations
15
Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1872 - 1872
Published: June 14, 2024
Folate is a water-soluble B vitamin involved in the synthesis of purines and pyrimidines one essential vitamins for human growth reproduction. deficiency due to low dietary intake, poor absorption folate, alterations folate metabolism genetic defects or drug interactions significantly increases risk diseases such as neural tube defects, cardiovascular disease, cancer, cognitive dysfunction. Recent studies have shown that can cause hyperhomocysteinemia, which hypertension high homocysteine levels are an independent factor liver fibrosis cirrhosis. In addition, results increased secretion pro-inflammatory factors impaired lipid liver, leading accumulation hepatocytes fibrosis. There substantial evidence contributes development progression variety diseases, including non-alcoholic fatty disease (NAFLD), steatohepatitis (NASH), alcoholic (ALD), viral hepatitis, hepatic fibrosis, cancer. Here we review key on role pathophysiology summarize current status treatment speculate may be potential therapeutic target diseases.
Language: Английский
Citations
12
Nature Cancer, Journal Year: 2024, Volume and Issue: 5(8), P. 1176 - 1194
Published: July 15, 2024
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients. The Genome Atlas (TCGA) is a compendium 'maps' detailing genetic, epigenetic and molecular changes occur during pathogenesis cancer, yet it lacks map translate gene essentiality in patient tumors. Here, we used machine learning build translational for tumors, which identified predict responses disease outcomes. A similar approach was tolerability healthy tissues prioritize with best therapeutic windows. subset patient-translatable synthetic lethalities were experimentally tested, including PAPSS1/PAPSS12 CNOT7/CNOT78, validated vitro vivo. Notably, PAPSS1 lethality driven by collateral deletion PAPSS2 PTEN correlated survival. Finally, provided web-based application exploring vulnerabilities.
Language: Английский
Citations
10
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(12), P. 979 - 1000
Published: Oct. 3, 2024
Language: Английский
Citations
10
International Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 21(4), P. 1530 - 1544
Published: Jan. 27, 2025
Globally, bladder cancer is the tenth most common cancer. Mitophagy, a critical process regulating mitochondrial quantity and quality, has attracted increasing attention for its pivotal function in Nonetheless, roles underlying mechanisms are yet to be elucidated. Therefore, this study, 16 mitophagy-related genes were screened construct robust prognostic model with exceptional predictive accuracy outcomes of patients Of these genes, DARS2 was identified as key regulator that significantly affected progression. The findings established promoted G1-to-S phase transition by upregulating CDK4 expression, thereby suppressing cellular senescence driving cell proliferation. In addition, augmented PINK1 leading increased PINK1-mediated mitophagy. Both vitro vivo experiments confirmed inhibited facilitated tumor progression enhancing observations from study have provided novel insights into multifaceted DARS2-mediated mitophagy Targeting regulation promising therapeutic strategy improve
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Metabolic reprogramming is one of the major biological features malignant tumors, playing a crucial role in initiation and progression cancer. The tumor microenvironment consists various non-cancer cells, such as hepatic stellate cancer-associated fibroblasts (CAFs), immune well extracellular matrix soluble substances. In liver cancer, metabolic not only affects its own growth survival but also interacts with other cells by influencing expression release metabolites cytokines (such lactate, PGE2, arginine). This interaction leads to acidification restricts uptake nutrients resulting competition symbiosis. At same time, neighboring during proliferation differentiation processes impacts immunity. article provides comprehensive overview crosstalk between cancer their microenvironment, deepening our understanding relevant findings pathways. contributes further regulation development evasion mechanisms while providing assistance advancing personalized therapies targeting pathways for anti-cancer treatment.
Language: Английский
Citations
1
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(7)
Published: June 27, 2024
Abstract Hepatitis B virus (HBV) infection playsa significant role in the etiology and progression of liver‐relatedpathologies, encompassing chronic hepatitis, fibrosis, cirrhosis, eventual hepatocellularcarcinoma (HCC). Notably, HBV stands as primary etiologicalfactor driving development HCC. Given contribution ofHBV to liver diseases, a comprehensive understanding immunedynamics microenvironment, spanning infection,fibrosis, HCC, is essential. In this review, we focused on thefunctional alterations CD8 + T cells within pathogenic livermicroenvironment from We thoroughly reviewed roles ofhypoxia, acidic pH, metabolic reprogramming, amino acid deficiency, inhibitory checkpointmolecules, immunosuppressive cytokines, gut‐liver communication shapingthe dysfunction microenvironment. Thesefactors significantly impact clinical prognosis. Furthermore, comprehensivelyreviewed cell‐based therapy strategies for diseases,encompassing infection, Strategies includeimmune checkpoint blockades, T‐cell targeting therapy, therapeuticT‐cell vaccination, adoptive transfer genetically engineered cells, along with combined usage programmed cell death protein‐1/programmeddeath ligand‐1 (PD‐1/PD‐L1) inhibitors mitochondria‐targeted antioxidants.Given that at various stages hepatitis Bvirus‐induced hepatocellular carcinoma (HBV HCC) shows promise, reviewedthe ongoing need research elucidate complex interplay between microenvironment toHCC. also discussed personalized treatment regimens, combining therapeuticstrategies harnessing gut microbiota modulation, which holds potential forenhanced benefits. conclusion, review delves into changes, during HCC progression, andrelated diseases.
Language: Английский
Citations
7
Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 149, P. 104532 - 104532
Published: May 14, 2024
Language: Английский
Citations
5
Frontiers in Epigenetics and Epigenomics, Journal Year: 2024, Volume and Issue: 2
Published: July 31, 2024
The crosstalk between metabolism and epigenetics is an emerging field that gaining importance in different areas such as cancer aging, where changes significantly impacts the cellular epigenome, turn dictating chromatin adaptive mechanism to bring back metabolic homeostasis. A key pathway influencing organism's epigenetic state one-carbon (OCM), which includes folate methionine cycles. Together, these cycles generate S-adenosylmethionine (SAM), universal methyl donor essential for DNA histone methylation. SAM serves sole group methyltransferases, making it a crucial metabolite modifications. In this review, we will discuss how its byproduct, S-adenosylhomocysteine (SAH), along with enzymes cofactors involved OCM, may function compartments, particularly nucleus, directly regulate epigenome aging cancer.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Abstract Proteins have emerged as promising therapeutics in oncology due to their great specificity. Many treatment strategies are developed based on protein biologics, such immunotherapy, starvation therapy, and pro‐apoptosis while some biologics entered the clinics. However, clinical translation is severely impeded by instability, short circulation time, poor transmembrane transportation, immunogenicity. Micro‐ nano‐particles‐based drug delivery platforms designed solve those problems enhance therapeutic efficacy. This review first summarizes different types of proteins research stages, highlighting administration limitations. Next, various micro‐ nano‐particles described demonstrate how they can overcome The potential then explored efficacy combinational therapies. Finally, challenges future directions carriers discussed for optimized delivery.
Language: Английский
Citations
4