Cancer Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 217391 - 217391
Published: Dec. 1, 2024
Circadian
rhythm,
regulated
by
a
time
keeping
system
termed
as
the
circadian
clock,
is
important
for
many
biological
processes
in
eukaryotes.
Disordered
rhythm
implicated
different
human
diseases,
including
cardiovascular
disease,
neurologic
metabolic
disorders,
and
cancer.
The
stem
like-cancer
cells
(or
cancer
cells,
CSCs)
are
proposed
to
stand
at
top
of
heterogeneous
hierarchy
solid
tumors,
which
responsible
tumor
initiation,
development,
therapy
resistance
metastasis.
Emerging
evidence
has
shown
that
clock
genes
potentially
regulate
stemness
features
CSCs
several
malignant
systems,
leukemia,
glioblastoma,
breast
cancer,
colorectal
prostate
chronotherapies
targeting
therefore
therapeutic
potentials
treating
malignancies.
In
this
review,
we
have
summarized
our
current
knowledge
gene
regulation
normal
stem/progenitor
cells.
Moreover,
provided
linking
dysregulations
development.
Importantly,
listed
potential
mechanisms
underlying
CSCs.
Finally,
offered
attempts
chronotherapy
Elucidating
molecular
will
provide
us
novel
direction
development
therapeutics
target
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7530 - 7530
Published: July 9, 2024
Aging
is
a
multifaceted
process
influenced
by
hereditary
factors,
lifestyle,
and
environmental
elements.
As
time
progresses,
the
human
body
experiences
degenerative
changes
in
major
functions.
The
external
internal
signs
of
aging
manifest
various
ways,
including
skin
dryness,
wrinkles,
musculoskeletal
disorders,
cardiovascular
diseases,
diabetes,
neurodegenerative
cancer.
Additionally,
cancer,
like
aging,
complex
disease
that
arises
from
accumulation
genetic
epigenetic
alterations.
Circadian
clock
dysregulation
has
recently
been
identified
as
an
important
risk
factor
for
cancer
development.
Natural
compounds
herbal
medicines
have
gained
significant
attention
their
potential
preventing
age-related
diseases
inhibiting
progression.
These
demonstrate
antioxidant,
anti-inflammatory,
anti-proliferative,
pro-apoptotic,
anti-metastatic,
anti-angiogenic
effects
well
circadian
regulation.
This
review
explores
cancers,
specific
natural
targeting
key
features
these
conditions.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Circadian
rhythm
is
a
self-regulating
24-hour
system
that
synchronizes
with
the
day
and
night
cycle
in
organisms.
The
regulation
of
this
controlled
by
clock
genes,
which
function
to
harmoniously
express
molecular
levels
facilitate
orderly
coordination
various
cellular
processes,
such
as
sleep,
metabolism,
endocrine
function,
cell
proliferation
immunity.
root
cause
tumorigenesis
body
loses
its
normal
growth
at
genetic
level.
Long-term
disruptions
circadian
rhythms
caused
factors
shift
work,
jet
lag,
unstable
sleep
patterns
can
impact
health,
leading
health
problems,
including
cancer.
controls
most
functions
related
cancer
progression,
has
significant
on
ability
immune
cells
detect
promote
their
clearance
crucial
implication
for
future
tumor
immunotherapy.
This
article
aims
review
crosstalk
between
dysregulation
tumorigenesis,
response.
Additionally,
we
discuss
role
disruption
therapy,
highlighting
potential
optimize
treatment
timing
improve
therapeutic
outcomes.
Cellular and Molecular Immunology,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1215 - 1230
Published: Oct. 14, 2024
Dysregulation
of
lipid
metabolism
is
a
key
characteristic
the
tumor
microenvironment,
where
cells
utilize
lipids
for
proliferation,
survival,
metastasis,
and
evasion
immune
surveillance.
Lipid
has
become
critical
regulator
CD8+
T-cell-mediated
antitumor
immunity,
with
excess
in
microenvironment
impeding
T-cell
activities.
Considering
limited
efficacy
immunotherapy
many
solid
tumors,
targeting
to
enhance
effector
functions
could
significantly
improve
outcomes.
In
this
review,
we
examine
recent
findings
on
how
metabolic
processes,
including
uptake,
synthesis,
oxidation,
regulate
T
within
tumors.
We
also
assessed
impact
different
particular
focus
affects
mitochondrial
function
tumor-infiltrating
cells.
Furthermore,
as
cancer
systemic
disease,
examined
factors
linking
function.
Finally,
summarize
current
therapeutic
approaches
that
target
increase
immunity
immunotherapy.
Understanding
molecular
functional
interplay
between
offers
promising
opportunities
treatment.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 17, 2025
The
study
of
the
multifaceted
interactions
between
neuroscience
and
cancer
is
an
emerging
field
with
significant
implications
for
understanding
tumor
biology
innovation
in
therapeutic
approaches.
Increasing
evidence
suggests
that
neurological
functions
are
connected
tumorigenesis.
In
particular,
peripheral
central
nervous
systems,
synapse,
neurotransmitters,
neurotrophins
affect
progression
metastasis
through
various
regulatory
approaches
immune
microenvironment.
this
review,
we
summarized
tumorigenesis
metastasis,
which
controlled
by
systems.
We
also
explored
roles
neurotransmitters
progression.
Moreover,
examined
interplay
system
have
identified
drugs
target
treatment.
review
present
work
supporting
agent
targeting
could
potential
to
improve
therapy.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Despite
significant
advancements
in
identifying
novel
therapeutic
targets
and
compounds,
cancer
stem
cells
(CSCs)
remain
pivotal
driving
resistance
tumor
progression
gastric
(GC).
High‐resolution
knowledge
of
the
transcriptional
programs
underlying
role
CSC
niche
stemness
is
still
lacking.
Herein,
spatial
single‐cell
RNA
sequencing
32
human
mucosa
tissues
at
various
stages
malignancy,
illuminating
phenotypic
plasticity
epithelium
trajectory
from
mature
chief
to
state,
which
associated
with
activation
EGFR
WNT
signaling
pathways,
conducted.
Moreover,
CSCs
interact
not
only
immunosuppressive
CXCL13
+
T
CCL18
M2
macrophages
evade
immune
surveillance,
but
also
inflammatory
cancer‐associated
fibroblasts
(iCAFs)
promote
tumorigenesis
maintain
stemness,
construct
leading
inferior
prognosis.
Notably,
it
uncovered
that
amphiregulin
(AREG)
derived
iCAFs
promotes
by
upregulating
expression
SOX9
cells,
contributes
drug
via
AREG‐ERBB2
axis.
This
study
provides
valuable
insight
into
characteristics
progression,
offering
perspective
for
designing
effective
strategies
overcome
GC
therapy
resistance.
MedComm – Oncology,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: Feb. 17, 2025
ABSTRACT
Metastasis
remains
a
leading
cause
of
cancer‐related
deaths,
defined
by
complex,
multi‐step
process
in
which
tumor
cells
spread
and
form
secondary
growths
distant
tissues.
Despite
substantial
progress
understanding
metastasis,
the
molecular
mechanisms
driving
this
development
effective
therapies
remain
incompletely
understood.
Elucidating
pathways
governing
metastasis
is
essential
for
discovery
innovative
therapeutic
targets.
The
rapid
advancements
sequencing
technologies
expansion
biological
databases
have
significantly
deepened
our
drivers
associated
drug
resistance.
This
review
focuses
on
particularly
roles
genetic
mutations,
epigenetic
changes,
post‐translational
modifications
progression.
We
also
examine
how
microenvironment
influences
metastatic
behavior
explore
emerging
strategies,
including
targeted
immunotherapies.
Finally,
we
discuss
future
research
directions,
stressing
importance
novel
treatment
approaches
personalized
strategies
to
overcome
improve
patient
outcomes.
By
integrating
contemporary
insights
into
basis
innovation,
provides
comprehensive
framework
guide
clinical
cancer.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 20, 2025
Lung
cancer,
a
leading
cause
of
mortality
worldwide,
necessitates
effective
therapeutic
strategies.
Caragana
jubata,
traditional
Chinese
medicinal
plant,
harbors
Texasin,
potential
anti-tumor
agent.
This
study
aimed
to
evaluate
the
anti-cancer
effects
Texasin
on
lung
cancer
cells,
while
assessing
its
impact
normal
cells.
The
utilized
cell
lines
H1299
and
A549,
alongside
embryonic
investigate
Texasin's
through
Cell
Counting
Kit-8,
Transwell,
wound
healing
assays.
Transcriptome
sequencing
analysis
were
performed
identify
mechanisms.
β-galactosidase
activity
Retinoblastoma(RB)
protein
expression
assessed,
autophagy
apoptosis
explored
chloroquine
co-treatment.
Mice
bearing
cell-derived
tumors
treated
with
Texasin.
Tumor
changes
assessed
in
vivo
imaging,
levels
within
analyzed.
inhibited
proliferation,
migration,
invasion
without
harming
It
promoted
senescence,
arrested
cycle
G1
phase,
upregulated
RB
expression.
induced
protective
autophagy,
which
could
be
converted
by
inhibits
proliferation
adenocarcinoma
cells
vivo,
as
evidenced
immunohistochemistry
showing
an
increase
tumors.
emerges
promising
non-cytotoxic
anti-lung
compound,
significantly
inhibiting
malignant
phenotypes,
highlighting
for
therapy.
