Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development DOI Creative Commons

Elena Gardey,

Johannes C. Brendel, Andreas Stallmach

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles DOI
Ming Jiang, Ying Chen, H. Miao

et al.

Nature Photonics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

27
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

20
Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging DOI
Wenjin Wang,

Zhuo-Yang Xin,

Xuxian Su

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

Citations

6
An Emerging Toolkit of Ho3+ Sensitized Lanthanide Nanocrystals with NIR-II Excitation and Emission for in Vivo Bioimaging DOI
Xusheng Wang,

Wenxiao Wu,

Baofeng Yun

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Optical imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for biomedical detection due to reduced tissue scattering and autofluorescence. However, rational design of NIR-II probes with superior excitation wavelengths balance effects water absorption remains a challenge. To address this issue, here we developed series Ho

Language: Английский

Citations

6
Activatable second-near-infrared-window multimodal luminogens with aggregation-induced-emission and aggregation-caused-quenching properties for step-imaging guided tumor therapy DOI Creative Commons
Wenxiu Li, Sixin Ai,

Huayong Zhu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 12, 2025

Traditional organic luminogens, such as aggregation-caused quenching or aggregation-induced emission only suitable to exhibit bright luminescence in the single state (i.e., solution aggregated state), restricting their applications heterogeneous environments. Herein, we propose a class of / dual property multimodal which can simultaneously balance radiative and non-radiative decay processes both aggregation states, bridging gap between luminogens. By manipulating rigidity planes twisted groups molecules, successfully develop series dual-property dyes DPM-HD1-3 with excellent second near-infrared window (NIR-II) fluorescent, photoacoustic, photothermal properties signals. Based on characteristics DPM-HD3, construct CO-activated luminogen, DPM-HD3-CO, for step-imaging guided therapy tumor-bearing mice. DPM-HD3-CO overcome interference tumor heterogeneity, reveal relationship CO levels treatment response different steps via imaging. We expect that introduction concept luminogens would open up innovative avenue dye chemistry, offering greater possibilities future widespread areas biomedical imaging, energy. conventionally (e.g. limiting utility Here, authors report states.

Language: Английский

Citations

2
Quinoidal π-Bridges for a Fused-Ring Acceptor with Enhanced Near-Infrared-II Photothermal Therapy and Fluorescent Emission beyond 1500 nm DOI

Wuke Cao,

Xun Zhang, Xueqin Yang

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2687 - 2695

Published: May 31, 2024

The second near-infrared window (NIR-II, 1000–3000 nm) presents an attractive platform for phototheranostics due to improved tissue penetration. However, developing efficient phototheranostic agents this range a significant challenge. Herein, we report NIR-II organic theranostic agent, CNTIC-4F, based on fused-ring acceptor structure, which features absorption extending beyond 1200 nm and fluorescence emission reaching up 1800 nm. incorporation of proaromatic π-bridge, thieno[3,4-b]pyrazine (TP), enhances the quinoidal character reducing optical bandgap enhancing intermolecular interactions. In vivo imaging mouse vasculature with CNTIC-4F nanoparticles shows high-contrast 1500 under 1064 excitation. Furthermore, also exhibit high photothermal conversion efficiency 82% excitation, enabling effective imaging-guided therapy 4T1 tumors in mice. This study illustrates potential structures advanced deep-penetrating phototheranostics.

Language: Английский

Citations

10
Gold Nanoclusters as High Resolution NIR-II Theranostic Agents DOI Creative Commons
Nancy Sharma,

Walaa Mohammad,

Xavier Le Guével

et al.

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(7), P. 462 - 480

Published: June 18, 2024

In the realm of nanomaterials, atomically precise quasi-molecular gold nanoclusters (AuNCs) play a prime role due to their unique, stable, and highly tunable optical properties. They are extensively structure-engineered for modulation surface electronic states toward long wavelength photoluminescence, particularly in NIR-II (1000 1700 nm) window. Contrast agents with emission can potentially transform imaging terms higher spatial resolution, deeper tissue penetration, reduced autofluorescence. These advantages allow real-time living organisms observing disease progression treatment response. this short review, we discuss origin rationally designed AuNCs application high resolution vasculatures hard soft structures identification pathological conditions such as stroke injury. Further, recent employment these rapidly growing field tumor theranostics is also summarized. Final remarks provided on scope improvement properties persisting challenges clinical translation.

Language: Английский

Citations

9
Nanophotonic-enhanced photoacoustic imaging for brain tumor detection DOI Creative Commons

Ali Rizwan,

Badrinathan Sridharan,

Jin Hyeong Park

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.

Language: Английский

Citations

2
Advances in prostate-specific membrane antigen-targeted theranostics: from radionuclides to near-infrared fluorescence technology DOI Creative Commons

Zhongji Jiang,

Gaohaer Kadeerhan, Jin Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Prostate-Specific Membrane Antigen (PSMA) is a highly expressed and structurally unique target specific to prostate cancer (PCa). Diagnostic therapeutic approaches in nuclear medicine, coupling PSMA ligands with radionuclides, have shown significant clinical success. PSMA-PET/CT effectively identifies tumors metastatic lymph nodes for imaging purposes, while 177Lu-PSMA-617 (Pluvicto) has received FDA approval treating castration-resistant PCa (mCRPC). Despite their success, radionuclide-based diagnostic methods face limitations such as high costs side effects. Recently, near-infrared (NIR) fluorescence phototherapy advanced significantly biomedical applications. It's benefits, deep tissue penetration, real-time precision, minimal effects, driven broader adoption, especially fluorescence-guided surgery (FGS). This review suggests combining NIR dyes enable targeted, high-resolution superior signal-to-background ratios, facilitating precise FGS. techniques can also aid pathological diagnosis ex vivo specimens. Furthermore, photosensitizers allows localized photothermal (PTT) or photodynamic therapy (PDT) under irradiation, producing heat reactive oxygen species (ROS) treat PCa. aims extend the success of targeting by exploring advances NIR-based FGS phototherapy, presenting promising new approach.

Language: Английский

Citations

1
Synchronous Passivation Boosts the NIR-II Luminescence Efficiency of Ag2S Nanocrystals for Effective Deep Tissue Lymphatic Mapping DOI

Wei Ge,

Senhe Huang, Xiaoyu Huang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Silver sulfide nanocrystals (Ag2S NCs) with second near-infrared (NIR-II) emission and excellent biocompatibility hold great attraction for in vivo imaging. However, current Ag2S NCs suffer severely low photoluminescence quantum yields (PLQYs), limiting the penetration depth. Herein, based on computational prediction, we proposed a facile synchronous passivation strategy employing non-toxic MgCl2 as passivator simultaneous Mg-doping chlorination of (Syn-Ag2S). Spectroscopic studies including femtosecond transient absorption measurement (fs-TAS) temperature-dependent PL spectra revealed that syn-passivation successfully enlarged nonradiative activation energy reduced defect states exciton-photon interaction, thus resulting record high absolute PLQY 46 ± 2% at 1220 nm among toxic-element-free NIR-II probes. The boosted unlocks potential deep lymph node profile lumbar nodes was clearly distinguished by Syn-Ag2S, while clinical indocyanine green (ICG) failed to do so. This also establishes an approach developing other ultrabright used not only bioimaging but photovoltaics LEDs.

Language: Английский

Citations

1