Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities DOI Creative Commons
Qiuming Pan,

Zhu Ye,

Zhi Ting Ye

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Cellular senescence is characterized by a sustained and irreversible cessation of cell proliferation in response to diverse environmental stimuli. However, senescent cells exhibit strong metabolic activity release range cytokines inflammatory mediators into the tumor microenvironment, collectively referred as senescence‐associated secretory phenotype (SASP). In recent years, develop new therapies for cancers, researchers have conducted extensive studies on mechanism cancer revealed that induction could effectively suppress progression. it has been documented cellular not only inhibits initiation but also contributes significantly progression some cases. Hence, imperative comprehend correlation between tumorigenesis, discuss potential utilization mechanisms progression, which lays theoretical foundation drugs treat cancers. this review, we first provide an overview discovery its key milestone events. Meanwhile, review examines major stimulus senescence, provides categorization senescence. Subsequently, examination primary regulatory discussed, followed summary control SASP expression dual biological roles Additionally, common biomarkers utilized identification Finally, investigates efficacy “One‐Two punch” sequential treatment approach emerging challenges novel approach.

Language: Английский

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment DOI Creative Commons

V. Lelarge,

Remi Capelle,

Frédérik Oger

et al.

npj Aging, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 6, 2024

Abstract The involvement of cellular senescence in the initiation and propagation diseases is clearly characterized, making elimination senescent cells essential to treat age-related diseases. development senolytic drugs demonstrated that targeting these limits deterioration patients’ condition, by inducing apoptosis. Nevertheless, first generations senolytics which has been developed displayed their activities through specific mechanisms several limitations during clinical development. However, rational eliminate remains evident, with necessity develop therapies a context tissues. evolutions field drug discovery open way new generation therapies, such as immunological approaches (CAR-T cells, Antibody-Drug Conjugated or vaccines), require preliminary steps research identify markers specifically expressed on demonstrating promising effects. Currently, preclinical strategies appears more challenging avoid strong side effects, but expected results are commensurate hopes for treatments. In this review, we highlight fact classical approach based repurposing display limited efficacy probably reached its term recent complex extension interest domain different fields allow extend possibility discover powerful therapies. future treatment linked cell therapy immunotherapy offer best patients.

Language: Английский

Citations

29
Targeting aging and age-related diseases with vaccines DOI
R. H. Wu, Fei Sun, Weiqi Zhang

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(4), P. 464 - 482

Published: April 15, 2024

Language: Английский

Citations

25
Emerging prodrug and nano-drug delivery strategies for the detection and elimination of senescent tumor cells DOI
Tao Wang,

Xianbao Shi,

Xiaolong Xu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123129 - 123129

Published: Jan. 1, 2025

Language: Английский

Citations

2
Metabolic remodeling in cancer and senescence and its therapeutic implications DOI
Yeonju Kim, Yeji Jang, Mi-Sung Kim

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(8), P. 732 - 744

Published: March 6, 2024

Language: Английский

Citations

11
Insights and Interventions in Age-Associated Inflammation DOI
Haoyan Huang, Jie Ren, Guang‐Hui Liu

et al.

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 91, P. 102306 - 102306

Published: Jan. 20, 2025

Language: Английский

Citations

1
Immunosenescence promotes cancer development: from mechanisms to treatment strategies DOI Creative Commons

Leihan Wang,

Tang Dong

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 10, 2025

The body's innate immune system plays a pivotal role in identifying and eliminating cancer cells. However, as the ages, its functionality can deteriorate, becoming dysfunctional, inefficient, or even inactive—a condition referred to immunosenescence. This decline significantly increases risk of malignancies. While pro-cancer effects T-cell aging have been widely explored, there remains notable gap literature regarding impact on cells, such macrophages neutrophils. review seeks address this gap, with emphasis these cell types. Furthermore, although certain immunotherapies, including checkpoint inhibitors (ICIs), demonstrated efficacy across broad spectrum cancers, elderly patients are less likely derive clinical benefit from treatments. In some cases, they may experience immune-related adverse events (irAEs). senolytic strategies shown promise exerting anti-cancer effects, their reactions potential off-target present significant challenges. aims elucidate immunosenescence, implications for safety ICIs, anti-aging treatment strategies. addition, optimizing therapies minimize enhance therapeutic outcomes critical focus future research endeavors. Senescence is an inevitable phenomenon human body, scientists explored specific mechanisms by which immunosenescence advances development cancer. summarizes characteristics be used level surveillance cancers due "Targeting immunosenescence" new idea strategy therapy.

Language: Английский

Citations

1
Therapy-Induced Cellular Senescence: Potentiating Tumor Elimination or Driving Cancer Resistance and Recurrence? DOI Creative Commons
Yue Liu,

Isabelle Lomeli,

Stephen J. Kron

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1281 - 1281

Published: July 30, 2024

Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, role response to deregulated proliferation oncogenic stress, induction by cancer therapies. While therapy-induced (TIS) linked resistance, recurrence, metastasis, normal tissue toxicity, TIS also the potential enhance therapy stimulate anti-tumor immunity. In this review, we examine Jekyll Hyde nature senescent cells (SnCs), focusing on how their persistence while expressing senescence-associated secretory phenotype (SASP) modulates tumor microenvironment through autocrine paracrine mechanisms. Through SASP, SnCs can mediate both resistance To fulfill unmet immunotherapy, consider may influence inflammation serve an antigen source potentiate immune response. This new perspective suggests treatment approaches based checkpoint blockade. Finally, describe strategies for mitigating detrimental effects senescence, such modulating SASP or targeting SnC persistence, which overall benefits treatment.

Language: Английский

Citations

7
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience DOI Creative Commons

Marianna V. Wrona,

Rituparna Ghosh,

Kaitlyn Coll

et al.

Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5

Published: Oct. 16, 2024

As we age, our immune system’s ability to effectively respond pathogens declines, a phenomenon known as immunosenescence. This age-related deterioration affects both innate and adaptive immunity, compromising function leading chronic inflammation that accelerates aging. Immunosenescence is characterized by alterations in cell populations impaired functionality, resulting increased susceptibility infections, diminished vaccine efficacy, higher prevalence of diseases. Chronic low-grade further exacerbates these issues, contributing decline overall health resilience. review delves into the characteristics immunosenescence examines various intrinsic extrinsic factors aging how hallmarks fates can play crucial role this process. Additionally, it discusses impact sex, social determinants, gut microbiota on aging, illustrating complex interplay altering function. Furthermore, concept resilience explored, focusing metrics for assessing identifying strategies enhance These include lifestyle interventions such diet, regular physical activity, stress management, use gerotherapeutics other approaches. Understanding mitigating effects are developing support robust responses aged individuals.

Language: Английский

Citations

7
Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics DOI Creative Commons

Xuewen Deng,

Hiroshi Terunuma

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 26, 2024

Abstract The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs). Unfortunately, immunosenescence, progressively dysregulated immunity age, hampers effective SNC elimination, leading to accumulation, coupled the release of SASPs, which, turn, inhibits heightened susceptibility aging-associated diseases (AADs). Natural killer (NK) cells, integral innate system, play pivotal addressing SNCs swiftly. These also coordinate other components both adaptive surveil eliminate these cells. Accordingly, preserving NK cell function during is for evading AADs promoting healthy aging. Alternatively, NK-cell-based therapies present promising avenues challenges associated Notable, recent studies adoptive therapy have shown promise rejuvenating eliminating SNCs, alleviating SASPs. This progress provides proof-concept senotherapy holds as an emerging revolution longevity therapeutics.

Language: Английский

Citations

6
The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review DOI Creative Commons
D.S. Jang, J W Shin, Eunha Shim

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)

Published: Aug. 15, 2024

Abstract The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, predisposition age‐associated diseases. Cellular senescence, characterized by cessation of cell division response various stressors, induces morphological functional changes within tissues. complexity heterogeneity senescent cells, alongside secretion senescence‐associated secretory phenotype, exacerbate process through pro‐inflammatory pathways influence microenvironment immune system. Concurrently, aging‐associated diversity composition contribute dysbiosis, further exacerbating inflammation undermining integrity bodily functions. This review encapsulates burgeoning research on reciprocal relationship highlighting their collective impact age‐related musculoskeletal diseases, including osteoporosis, sarcopenia, osteoarthritis. It also explores potential modulating targeting innovative strategies healthy mitigating progression aging‐related conditions. By exploring targeted interventions, development senotherapeutic drugs probiotic therapies, this aims shed light novel therapeutic avenues. These leverage connection advance interventions aimed at extending health span improving quality life older population.

Language: Английский

Citations

6