arXiv (Cornell University),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 1, 2023
In
Magnetic
Particle
Imaging,
a
field-free
region
is
maneuvered
throughout
the
field
of
view
using
time-varying
magnetic
known
as
drive-field.
Human-sized
systems
operate
drive-field
in
kHz
range
and
generate
it
by
utilizing
strong
currents
that
can
rise
to
kA
within
coil
called
drive
generator.
Matching
tuning
between
power
amplifier,
band-pass
filter
generator
required.
Here,
for
reasons
safety
future
human
scanners,
symmetrical
topology
transformer,
inductive
coupling
network
used.
Our
primary
objectives
are
achieve
floating
potentials
ensure
patient
safety,
attaining
high
linearity
gain
resonant
transformer.
We
present
novel
systematic
approach
design
loss-optimized
toroid
with
D-shaped
cross
section,
employing
segmentation
adjust
inductance-to-resistance
ratio
while
maintaining
constant
quality
factor.
Simultaneously,
we
derive
specific
matching
condition
symmetric
transmit-receive
circuit
particle
imaging.
The
chosen
setup
filters
fundamental
frequency
allows
simultaneous
signal
transmission
reception.
addition,
decoupling
multiple
channels
discussed
side
transformer
evaluated
maximum
minimum
stray
field.
Two
prototypes
were
constructed,
measured,
decoupled,
compared
derived
theory
method-of-moment
based
simulations.
Sensors,
Journal Year:
2025,
Volume and Issue:
25(3), P. 665 - 665
Published: Jan. 23, 2025
Active
drug
delivery
systems
for
cancer
therapy
are
gaining
attention
their
biocompatibility
and
enhanced
efficacy
compared
to
conventional
chemotherapy
surgery.
To
improve
precision
in
targeted
(TDD),
actuating
devices
using
external
magnetic
fields
employed.
However,
a
key
challenge
is
the
inability
visually
track
carriers
blood
vessels,
complicating
navigation
target.
Magnetic
particle
imaging
(MPI)
can
localize
(MCs)
but
rely
on
bulky
electromagnetic
coils
generate
static
field
gradient,
creating
field-free
point
(FFP)
within
of
view
(FOV).
Also,
additional
required
move
FFP
across
FOV,
limiting
flexibility
increasing
system
size.
address
these
issues,
we
propose
non-FFP-based,
open-type
RF
coil
with
simplified
structure
composed
Tx/Rx
permanent
magnet
at
center,
eliminating
need
an
FFP.
Furthermore,
integrating
robotic
arm
assembly
enables
easy
adjustment
FOV
size
location.
Finally,
tests
nanoparticles
(MNPs)
confirmed
system’s
ability
detect
minimum
mass
0.3
mg
(Fe)
80
×
mm2.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 20, 2025
Abstract
Current
single
imaging
modalities
typically
lack
the
ability
to
simultaneously
offer
detailed
anatomical
visualization
and
quantitative
cellular
information,
which
is
crucial
for
evaluating
improving
therapeutic
efficacy.
We
developed
a
quad-modal
nanocomplex
magnetic
resonance
(MRI),
particle
(MPI),
computed
tomography
(CT),
multispectral
optoacoustic
(MSOT)
within
nanoplatform.
The
chemically
engineered
complex
composed
of
bovine
serum
albumin
as
biocompatible
matrix,
superparamagnetic
iron
oxide
MRI
MPI
agents,
optoradiopaque
bismuth
sulfide
CT
MSOT
agents.
demonstrate
here
its
use
high-resolution,
real-time,
in
vivo
mesenchymal
stem
cells
transplanted
mouse
brain.
This
versatile
may
find
applications
monitoring
cell
transfer
transplantation
using
multiple
approaches.
Review of Scientific Instruments,
Journal Year:
2024,
Volume and Issue:
95(4)
Published: April 1, 2024
In
magnetic
particle
imaging,
a
field-free
region
is
maneuvered
throughout
the
field
of
view
using
time-varying
known
as
drive-field.
Human-sized
systems
operate
drive-field
in
kHz
range
and
generate
it
by
utilizing
strong
currents
that
can
rise
to
kA
within
coil
called
drive
generator.
Matching
tuning
between
power
amplifier,
band-pass
filter,
generator
required.
Here,
for
reasons
safety
future
human
scanners,
symmetrical
topology
transformer
an
inductive
coupling
network
are
used.
Our
primary
objectives
achieve
floating
potentials
ensure
patient
while
attaining
high
linearity
gain
resonant
transformer.
We
present
novel
systematic
approach
design
loss-optimized
toroid
with
D-shaped
cross
section,
employing
segmentation
adjust
inductance-to-resistance
ratio
maintaining
constant
quality
factor.
Simultaneously,
we
derive
specific
matching
condition
symmetric
transmit–receive
circuit
imaging.
The
chosen
setup
filters
fundamental
frequency
allows
simultaneous
signal
transmission
reception.
addition,
decoupling
multiple
channels
discussed,
side
evaluated
maximum
minimum
stray
field.
Two
prototypes
were
constructed,
measured,
decoupled,
compared
derived
theory
method-of-moment
based
simulations.
Advanced Intelligent Systems,
Journal Year:
2024,
Volume and Issue:
6(11)
Published: Aug. 22, 2024
Magnetic
field
generators
are
a
key
component
of
Particle
Imaging
(MPI)
systems,
and
their
power
consumption
is
major
obstacle
on
the
path
to
human‐sized
scanners.
Despite
importance,
focused
discussion
these
rare,
comprehensive
description
design
process
currently
lacking.
This
work
presents
methodology
for
optimization
selection
operating
with
soft
magnetic
materials
outside
linear
regime
in
context
MPI.
Key
elements
mathematical
model
generators,
formalism
defining
sequences,
relationship
between
sequence.
These
used
define
space
generator
given
its
system
requirements
constraints.
The
then
formulated
as
an
problem.
Subsequently,
this
utilized
new
specifically
cerebral
imaging
studies.
result
outperforms
our
existing
MPI
terms
view
size,
providing
proof‐of‐concept
entire
methodology.
As
approach
very
general,
it
can
be
extended
beyond
other
areas
such
manipulation
medical
devices
micro‐robotics.
Physics in Medicine and Biology,
Journal Year:
2024,
Volume and Issue:
70(1), P. 015019 - 015019
Published: Dec. 11, 2024
Magnetic
particle
imaging
(MPI)
was
introduced
in
2005
as
a
promising,
tracer-based
medical
modality
with
the
potential
for
high
sensitivity
and
spatial
resolution.
Since
then,
numerous
preclinical
devices
have
been
built
but
only
few
human-scale
devices,
none
of
which
targeted
functional
neuroimaging.
In
this
work,
we
probe
challenges
scaling
technology
to
meet
needs
human
neuroimaging
sufficient
detecting
hemodynamic
changes
following
brain
activation
spatio-temporal
resolution
comparable
current
magnetic
resonance
approaches.
Physics in Medicine and Biology,
Journal Year:
2024,
Volume and Issue:
69(15), P. 155004 - 155004
Published: June 11, 2024
Magnetic
particle
imaging
(MPI)
is
an
emerging
medical
tomographic
modality
that
enables
real-time
with
high
sensitivity
and
spatial
temporal
resolution.
For
the
system
matrix
reconstruction
method,
MPI
problem
ill-posed
inverse
commonly
solved
using
Kaczmarz
algorithm.
However,
computation
time
of
algorithm,
which
restricts
speed,
has
limited
development
potential
clinical
applications
for
MPI.
In
order
to
achieve
fast
in
MPI,
we
propose
a
greedy
regularized
block
method
(GRBK)
accelerates
reconstruction.
