Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 15, 2023
Abstract
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
great
promise
in
the
treatment
of
cancer.
However,
there
are
many
obstacles
that
can
restrict
therapeutic
efficacy
phototherapy.
The
hypoxic
tumor
microenvironment
production
reactive
oxygen
species
(ROS)
PDT.
As
for
PTT,
thermotolerance
cancer
cells
may
lead
to
ineffective
PTT.
In
this
study,
IR780
glycolysis
inhibitor
lonidamine
(LND)-encapsulated
liposomes
prepared
hepatocellular
carcinoma.
be
used
as
a
photosensitizer
agent
simultaneous
PDT
PTT
after
being
irradiated
with
808
nm
laser.
LND
reduce
consumption
by
inhibiting
glycolysis,
which
will
relieve
hypoxia
produce
more
ROS
On
other
hand,
energy
supply
blocked
LND-induced
inhibition,
inhibit
heat
shock
proteins
(HSPs),
cells,
finally
enhance
enhanced
is
studied
measuring
intracellular
HSPs,
ATP
level,
mitochondrial
membrane
potential.
antitumor
effect
co-loaded
extensively
investigated
vitro
vivo
experiments.
This
research
provides
an
innovative
strategy
simultaneously
promising
future
creative
approaches
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(22)
Published: July 25, 2023
Abstract
Materialomics
integrates
experiment,
theory,
and
computation
in
a
high‐throughput
manner,
has
changed
the
paradigm
for
research
development
of
new
functional
materials.
Recently,
with
rapid
characterization
machine‐learning
technologies,
establishment
biomaterialomics
that
tackles
complex
physiological
behaviors
become
accessible.
Breakthroughs
clinical
translation
nanoparticle‐based
therapeutics
vaccines
have
been
observed.
Herein,
recent
advances
biomaterials,
including
polymers,
lipid‐like
materials,
peptides/proteins,
discovered
through
screening
or
machine
learning‐assisted
methods,
are
summarized.
The
molecular
design
structure‐diversified
libraries;
characterization,
screening,
preparation;
and,
their
applications
drug
delivery
discussed
detail.
Furthermore,
prospects
main
challenges
future
highlighted.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(9)
Published: Nov. 3, 2023
Abstract
Tumor
hypoxia
and
acidity,
two
general
features
of
solid
tumors,
are
known
to
have
negative
effect
on
cancer
immunotherapy
by
directly
causing
dysfunction
effector
immune
cells
promoting
suppressive
inside
tumors.
Herein,
a
multifunctional
colloidosomal
microreactor
is
constructed
encapsulating
catalase
within
calcium
carbonate
(CaCO
3
)
nanoparticle‐assembled
colloidosomes
(abbreviated
as
CaP
CSs)
via
the
classic
double
emulsion
method.
The
yielded
CCaP
CSs
exhibit
well‐retained
proton‐scavenging
hydrogen
peroxide
decomposition
performances
can
thus
neutralize
tumor
attenuate
hypoxia,
suppress
lactate
production
upon
intratumoral
administration.
Consequently,
treatment
activate
potent
antitumor
immunity
significantly
enhance
therapeutic
potency
coloaded
anti‐programmed
death‐1
(anti‐PD‐1)
antibodies
in
both
murine
subcutaneous
CT26
orthotopic
4T1
xenografts.
In
addition,
such
also
markedly
reinforces
epidermal
growth
factor
receptor
expressing
chimeric
antigen
T
(EGFR‐CAR‐T)
toward
human
triple‐negative
breast
xenograft
their
infiltration
cytokine
secretion.
Therefore,
this
study
highlights
that
chemical
modulation
acidity
collectively
reverse
immunosuppression
potentiate
checkpoint
blockade
CAR‐T
cell
immunotherapies
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(8)
Published: Nov. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 15, 2023
Abstract
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
great
promise
in
the
treatment
of
cancer.
However,
there
are
many
obstacles
that
can
restrict
therapeutic
efficacy
phototherapy.
The
hypoxic
tumor
microenvironment
production
reactive
oxygen
species
(ROS)
PDT.
As
for
PTT,
thermotolerance
cancer
cells
may
lead
to
ineffective
PTT.
In
this
study,
IR780
glycolysis
inhibitor
lonidamine
(LND)-encapsulated
liposomes
prepared
hepatocellular
carcinoma.
be
used
as
a
photosensitizer
agent
simultaneous
PDT
PTT
after
being
irradiated
with
808
nm
laser.
LND
reduce
consumption
by
inhibiting
glycolysis,
which
will
relieve
hypoxia
produce
more
ROS
On
other
hand,
energy
supply
blocked
LND-induced
inhibition,
inhibit
heat
shock
proteins
(HSPs),
cells,
finally
enhance
enhanced
is
studied
measuring
intracellular
HSPs,
ATP
level,
mitochondrial
membrane
potential.
antitumor
effect
co-loaded
extensively
investigated
vitro
vivo
experiments.
This
research
provides
an
innovative
strategy
simultaneously
promising
future
creative
approaches
