Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study DOI Creative Commons
Yang Li, Yahu Miao, Qing Feng

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

Mitochondrial dysfunction plays a crucial role in Type 2 Diabetes Mellitus (T2DM) and its complications. However, the genetic pathophysiology remains under investigation. Through multi-omics Mendelian Randomization (MR) colocalization analyses, we identified mitochondrial-related genes causally linked with T2DM

Language: Английский

Colorimetric and fluorescent dual-modality assay for cell-free mitochondrial DNA copy number in saliva DOI

Jiaxu Wang,

Zheng‐Rong Lu, Zhanmin Liu

et al.

Analytical Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 115840 - 115840

Published: March 1, 2025

Language: Английский

Citations

0
A positive association between high dietary medium-chain fatty acids intake and depression: Mediation of inflammation DOI
L.-H. Zeng, Fengping Zhang

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells DOI Creative Commons

Huanhuan Qin,

Meixi Peng,

Jingsong Cheng

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(7)

Published: July 5, 2024

Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species highly abundant essential component human cells, which often changed in tumor microenvironment. LSCs remodel lipid metabolism to sustain stemness. However, there is no useful related biomarker has been approved for clinical practice AML prediction treatment. Here, we constructed verified fatty acid metabolism-related risk score (LFMRS) model based on TCGA database via a series bioinformatics analysis, univariate COX regression multivariate found that LFMRS could be an independent factor predict survival time patients combined with age. Moreover, revealed Galectin-1 (LGALS1, key gene LFMRS) was expressed associated poor prognosis patients, LGALS1 repression inhibited cell LSC proliferation, enhanced apoptosis, decreased accumulation vitro. curbed progression, accumulation, CD8

Language: Английский

Citations

3
Comparative proteomic analysis of renal tissue of normotensive and hypertensive rats DOI Open Access
О.А. Бунеева,

V.I. Fedchenko,

S.A. Kaloshina

et al.

Biomeditsinskaya Khimiya, Journal Year: 2024, Volume and Issue: 70(2), P. 89 - 98

Published: Jan. 1, 2024

Comparative proteomic analysis of kidney tissue from normotensive (WKY) and spontaneously hypertensive (SHR) rats revealed quantitative qualitative changes in renal proteins. The number proteins specific for WKY (blood pressure 110–120 mm Hg) was 13–16. There were 20–24 SHR 180 Hg more). total identified common both rat strains included 972–975 A pairwise comparison all possible (SHR-WKY) variants 8 only animals, 7 ones (SHR). Taking into consideration their biological roles, the lack some enzyme (for example, biliverdin reductase A) reduces production molecules exhibiting antihypertensive properties, while appearance others (e.g. betaine-homocysteine S-methyltransferase 2, septin etc.) can be interpreted as a compensatory reaction. Renal with altered relative content (with more than 2.5-fold change) accounted no 5% Among an increased largest group consisted involved processes energy generation carbohydrate metabolism, well antioxidant protective In context development hypertension, apparently considered compensatory. most pronounced decrease rats, dramatic reduction acyl-CoA medium-chain synthetase-3 (ACSM3) appears to make important contribution pathology these animals.

Language: Английский

Citations

2
MAPK signaling pathway induced LOX-1+ polymorphonuclear myeloid-derived suppressor cells in biliary atresia DOI
Cheng Chen,

Hezhen Wang,

Lili Xu

et al.

Clinical Immunology, Journal Year: 2024, Volume and Issue: 268, P. 110355 - 110355

Published: Sept. 3, 2024

Language: Английский

Citations

1
Proteomics exploration of metformin hydrochloride for diabetic kidney disease treatment via the butanoate metabolism pathway DOI

Jiyun Chai,

Yan Wang,

Sifan Guo

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 254, P. 116584 - 116584

Published: Nov. 26, 2024

Language: Английский

Citations

1
Chewing the fat for good health: ACSM3 deficiency exacerbates metabolic syndrome DOI Creative Commons
Juliana Cazarin, Brian J. Altman

The EMBO Journal, Journal Year: 2024, Volume and Issue: 43(4), P. 481 - 483

Published: Jan. 23, 2024

The origin of metabolic syndrome, a pathophysiological condition facilitating cardiovascular disease, diabetes, and other comorbidities, remains poorly understood. Recent work by Xiao et al (2023) identifies the mitochondrial enzyme ACSM3 as determinant lipid homeostasis hepatic health in mice patients. Additionally, authors identified deleterious downstream p38-MAPK signalling targetable feature deficiency that may help to ameliorate syndrome.

Language: Английский

Citations

0
Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study DOI Creative Commons
Yang Li, Yahu Miao, Qing Feng

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

Mitochondrial dysfunction plays a crucial role in Type 2 Diabetes Mellitus (T2DM) and its complications. However, the genetic pathophysiology remains under investigation. Through multi-omics Mendelian Randomization (MR) colocalization analyses, we identified mitochondrial-related genes causally linked with T2DM

Language: Английский

Citations

0