DNA methylation, histone acetylation in the regulation of memory and its modulation during aging
Frontiers in Aging,
Journal Year:
2025,
Volume and Issue:
5
Published: Jan. 6, 2025
Memory
formation
is
associated
with
constant
modifications
of
neuronal
networks
and
synaptic
plasticity
gene
expression
in
response
to
different
environmental
stimuli
experiences.
Dysregulation
affects
memory
during
aging
neurodegenerative
diseases.
Covalent
such
as
methylation
on
DNA
acetylation
histones
regulate
the
transcription
genes.
Changes
these
epigenetic
marks
correlated
alteration
aging.
These
modifications,
turn,
are
regulated
by
physiology
metabolism.
Steroid
hormone
estrogen
metabolites
S-adenosyl
methionine
acetyl
CoA
directly
impact
histones'
levels.
Thus,
decline
levels
or
imbalance
underlying
brain
functions.
In
present
review,
we
discussed
importance
histone
chromatin
regulation
consolidation,
modulation
modifiers
phytochemicals
vitamins.
Further,
understanding
molecular
mechanisms
that
modulate
will
help
develop
recovery
approaches.
Language: Английский
Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 6, 2025
Neurodegenerative
diseases
including
Alzheimer's
and
Parkinson's
disease
are
age-related
disorders
which
severely
impact
quality
of
life
impose
significant
societal
burdens.
Cellular
senescence
is
a
critical
factor
in
these
disorders,
contributing
to
their
onset
progression
by
promoting
permanent
cell
cycle
arrest
reducing
cellular
function,
affecting
various
types
cells
brain.
Recent
advancements
regenerative
medicine
have
highlighted
"R3"
strategies-rejuvenation,
regeneration,
replacement-as
promising
therapeutic
approaches
for
neurodegeneration.
This
review
aims
critically
analyze
the
role
neurodegenerative
organizes
within
R3
paradigm.
Specifically,
we
examine
stem
therapy,
direct
lineage
reprogramming,
partial
reprogramming
context
R3,
emphasizing
how
interventions
mitigate
counteracting
aging-related
Ultimately,
this
seeks
provide
insights
into
complex
interplay
between
neurodegeneration
while
highlighting
promise
cell-based
strategies
address
debilitating
conditions.
Language: Английский
Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
ABSTRACT
Aging
is
a
multifactorial
biological
process
resulting
in
physiological
and
cellular
decline.
However,
our
understanding
of
age-related
changes
3D
genome
organization
the
effect
external
interventions
on
this
process,
remains
limited.
Here
we
describe
alterations
landscape
chromatin
interactome
upon
aging,
utilizing
low
input
Promoter
Capture
Hi-C
(liCHi-C)
technique
with
hippocampal
neurons.
We
integrated
liCHi-C
data
RNA-seq
to
identify
functional
implications.
Furthermore,
assessed
exposure
environmental
enrichment
(EE).
Remarkably,
results
demonstrated
an
age-
dependent
modulation
promoter
interactions
expression
EE,
aging-like
induced
young
mice
likely
associated
early
brain
maturation;
while
were
reverted
old
mice,
leading
partial
rejuvenation
aged
mouse
hippocampi.
These
findings
revealed
dynamic
behaviour
neuronal
structure
over
time,
which
can
be
modulated
by
interventions.
Language: Английский