The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise DOI Creative Commons
Jørgen Jensen,

Per Inge Rustad,

Anders J. Kolnes

et al.

Frontiers in Physiology, Journal Year: 2011, Volume and Issue: 2

Published: Jan. 1, 2011

Glycogen is the storage form of carbohydrates in mammals. In humans majority glycogen stored skeletal muscles (∼500 g) and liver (∼100 g). Food supplied larger meals, but blood glucose concentration has to be kept within narrow limits survive stay healthy. Therefore, body cope with periods excess without supplementation. Healthy persons remove rapidly when excess, insulin-stimulated disposal reduced insulin resistant type 2 diabetic subjects. During a hyperinsulinemic euglycemic clamp, 70-90% will as muscle healthy The stores are limited because an efficient feedback-mediated inhibition synthase prevents accumulation. De novo lipid synthesis can contribute filled. Exercise physiologists normally consider glycogen's main function energy substrate. substrate during exercise intensity above 70% maximal oxygen uptake ([Formula: see text]) fatigue develops depleted active muscles. After exercise, rate increased replete stores, Indeed elevated after which, from evolutional point view, favor repletion preparation for new "fight or flight" events. modern society, allows that channeled de synthesis, which over time causes ectopic fat accumulation resistance. reduction meals development diabetes.

Language: Английский

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation DOI

Tina M. Thornton,

Gustavo Pedraza‐Alva, Bin Deng

et al.

Science, Journal Year: 2008, Volume and Issue: 320(5876), P. 667 - 670

Published: May 2, 2008

Glycogen synthase kinase 3β (GSK3β) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3β activity the primary mechanism that regulates this widely expressed active kinase. Although protein Akt inhibits by phosphorylation at N terminus, preventing Akt-mediated does not affect cell-survival pathway activated through substrate β-catenin. Here, we show p38 mitogen-activated (MAPK) also inactivates direct its C inactivation can lead to an accumulation MAPK–mediated occurs primarily brain thymocytes. Activation β-catenin–mediated signaling inhibition provides a potential for survival specific tissues.

Language: Английский

Citations

450
Zinc and diabetes — clinical links and molecular mechanisms DOI

Judith Jansen,

Wölfram Karges,

Lothar Rink

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2009, Volume and Issue: 20(6), P. 399 - 417

Published: May 13, 2009

Language: Английский

Citations

429
GSK3 and its interactions with the PI3K/AKT/mTOR signalling network DOI
Miguel A. Hermida, J. Dinesh Kumar, Nicholas R. Leslie

et al.

Advances in Biological Regulation, Journal Year: 2017, Volume and Issue: 65, P. 5 - 15

Published: June 27, 2017

Language: Английский

Citations

393
Glycogen synthase kinase 3: A key regulator of cellular fate DOI

Josephine E. Forde,

Trevor Dale

Cellular and Molecular Life Sciences, Journal Year: 2007, Volume and Issue: 64(15), P. 1930 - 1944

Published: May 26, 2007

Language: Английский

Citations

378
The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise DOI Creative Commons
Jørgen Jensen,

Per Inge Rustad,

Anders J. Kolnes

et al.

Frontiers in Physiology, Journal Year: 2011, Volume and Issue: 2

Published: Jan. 1, 2011

Glycogen is the storage form of carbohydrates in mammals. In humans majority glycogen stored skeletal muscles (∼500 g) and liver (∼100 g). Food supplied larger meals, but blood glucose concentration has to be kept within narrow limits survive stay healthy. Therefore, body cope with periods excess without supplementation. Healthy persons remove rapidly when excess, insulin-stimulated disposal reduced insulin resistant type 2 diabetic subjects. During a hyperinsulinemic euglycemic clamp, 70-90% will as muscle healthy The stores are limited because an efficient feedback-mediated inhibition synthase prevents accumulation. De novo lipid synthesis can contribute filled. Exercise physiologists normally consider glycogen's main function energy substrate. substrate during exercise intensity above 70% maximal oxygen uptake ([Formula: see text]) fatigue develops depleted active muscles. After exercise, rate increased replete stores, Indeed elevated after which, from evolutional point view, favor repletion preparation for new "fight or flight" events. modern society, allows that channeled de synthesis, which over time causes ectopic fat accumulation resistance. reduction meals development diabetes.

Language: Английский

Citations

374