The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets DOI Creative Commons
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Huntington's disease (HD) is a currently incurable neurogenerative disorder and typically characterized by progressive movement (including chorea), cognitive deficits (culminating in dementia), psychiatric abnormalities (the most common of which depression), peripheral symptoms gastrointestinal dysfunction). There are no approved disease‐modifying therapies available for HD, with death usually occurring approximately 10–25 years after onset, but some hold promising potential. HD subjects often burdened chronic diarrhea, constipation, esophageal gastric inflammation, susceptibility to diabetes. Our understanding the microbiota–gut–brain axis its infancy growing evidence from preclinical clinical studies suggests role gut microbial population imbalance (gut dysbiosis) pathophysiology. The brain can communicate through enteric nervous system, immune vagus nerve, microbiota‐derived‐metabolites including short‐chain fatty acids, bile branched‐chain amino acids. This review summarizes supporting demonstrating alterations bacterial fungal composition that may be associated HD. We focus on mechanisms dysbiosis compromise health, thus triggering neuroinflammatory responses, further highlight outcomes attempts modulate microbiota as therapeutic strategies Ultimately, we discuss dearth data need more longitudinal translational this nascent field. suggest future directions improve our association between microbes pathogenesis other ‘brain body disorders’.

Language: Английский

Interactions between the microbiota, immune and nervous systems in health and disease DOI
Thomas C. Fung, C. Anders Olson, Elaine Y. Hsiao

et al.

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(2), P. 145 - 155

Published: Jan. 16, 2017

Language: Английский

Citations

1579
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease DOI Open Access

Deepak Kumar Vijaya Kumar,

Se Hoon Choi,

Kevin J. Washicosky

et al.

Science Translational Medicine, Journal Year: 2016, Volume and Issue: 8(340)

Published: May 25, 2016

β-Amyloid protein oligomerization and fibrillization, known to be pathogenic in Alzheimer’s disease, may play a physiological role microbial entrapment innate immunity.

Language: Английский

Citations

861
Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection DOI Creative Commons
William A. Eimer,

Deepak Kumar Vijaya Kumar,

Nanda Kumar N. Shanmugam

et al.

Neuron, Journal Year: 2018, Volume and Issue: 99(1), P. 56 - 63.e3

Published: July 1, 2018

Language: Английский

Citations

559
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease DOI Creative Commons
Amy R. Nelson, Melanie D. Sweeney, Abhay P. Sagare

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2015, Volume and Issue: 1862(5), P. 887 - 900

Published: Dec. 18, 2015

Language: Английский

Citations

492
Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health DOI Open Access
Aimée Parker, Sónia Fonseca, Simon R. Carding

et al.

Gut Microbes, Journal Year: 2019, Volume and Issue: 11(2), P. 135 - 157

Published: Aug. 1, 2019

The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of bacteria, archaea, viruses, fungi, protozoa, coexisting in a mutualistic relationship with the host. When intestinal homeostasis is perturbed, function tract other organ systems, including brain, can be compromised. gut proposed to contribute blood-brain barrier disruption pathogenesis neurodegenerative diseases. While progress being made, better understanding interactions between microbes host cells, impact these have on signaling from brain now required. In this review, we summarise current evidence their metabolites integrity function, communication networks which they may modulate. We also discuss potential modulation strategies as therapeutic tools for promoting restoring health.

Language: Английский

Citations

489
Microbes and Alzheimer’s Disease DOI Open Access
Ruth F. Itzhaki, Richard Lathe, Brian J. Balin

et al.

Journal of Alzheimer s Disease, Journal Year: 2016, Volume and Issue: 51(4), P. 979 - 984

Published: April 12, 2016

We are researchers and clinicians working on Alzheimer’s disease (AD) or related topics, we write to express our concern that one particular aspect of the has been neglected, even thoug ...

Language: Английский

Citations

466
Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA† DOI Creative Commons
Antonia Ricci, Ana Allende,

Declan Bolton

et al.

EFSA Journal, Journal Year: 2017, Volume and Issue: 15(3)

Published: March 1, 2017

EFSA is requested to assess the safety of a broad range biological agents in context notification for market authorisation as sources food and feed additives, enzymes plant protection products. The qualified presumption (QPS) assessment was developed provide harmonised generic pre-assessment support risk assessments performed by EFSA's scientific Panels. unambiguously defined (at highest taxonomic unit appropriate purpose which an application intended), completeness body knowledge are assessed. Identified concerns are, where possible reasonable number, reflected 'qualifications' connection with recommendation QPS status. list recommended reviewed updated current opinion therefore becomes valid list. 2016 update reviews previously assessed microorganisms including bacteria, yeasts viruses used purposes following Extensive Literature Search strategy. units related new notifications received since 2013 opinion, were periodically evaluated status results published Statements BIOHAZ Panel.

Language: Английский

Citations

420
Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis DOI Creative Commons
Cláudia Y. Santos, Peter J. Snyder, Wen‐Chih Wu

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2017, Volume and Issue: 7(1), P. 69 - 87

Published: Jan. 1, 2017

Abstract As the population ages due to demographic trends and gains in life expectancy, incidence prevalence of dementia increases, need understand etiology pathogenesis becomes ever more urgent. Alzheimer's disease (AD), most common form dementia, is a complex disease, mechanisms which are poorly understood. The we learn about AD, questions raised our current conceptual models disease. In absence cure or means by slow progress, it may be prudent apply knowledge intersection between cardiovascular cerebrovascular foster efforts delay onset AD. This review discusses understanding epidemiology, genetics, pathophysiology AD vascular causes proposes future directions for research prevention.

Language: Английский

Citations

385
The Infectious Etiology of Alzheimer’s Disease DOI
Marta Sochocka, Katarzyna Zwolińska, Jerzy Leszek

et al.

Current Neuropharmacology, Journal Year: 2017, Volume and Issue: 15(7)

Published: March 15, 2017

Inflammation is a part of the first line defense body against invasive pathogens, and plays crucial role in tissue regeneration repair. A proper inflammatory response ensures suitable resolution inflammation elimination harmful stimuli, but when reactions are inappropriate it can lead to damage surrounding normal cells. The relationship between infections Alzheimer's Disease (AD) etiology, especially lateonset AD (LOAD) has been continuously debated over past three decades.This review discusses whether could be causative factor that promotes progression summarizes recent investigations associating infectious agents chronic with AD. Preventive therapeutic approaches context an etiology disease also discussed.Emerging evidence supports hypothesis neurotropic viruses from Herpesviridae family, Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), 2 (HHV-2), neuropathology. Recent indicate association Hepatitis C virus (HCV) infection dementia. Among bacteria special attention focused on spirochetes family periodontal pathogens such as Porphyromonas gingivalis or Treponema denticola cause periodontitis possibly contribute clinical onset AD.Chronic viral, bacterial fungal might factors for pathway

Language: Английский

Citations

338
The role of microbial amyloid in neurodegeneration DOI Creative Commons
Robert P. Friedland, Matthew R. Chapman

PLoS Pathogens, Journal Year: 2017, Volume and Issue: 13(12), P. e1006654 - e1006654

Published: Dec. 21, 2017

It has become apparent that the intestinal microbiota orchestrates important aspects of our metabolism, immunity, and development. Recent work demonstrated also influences brain function in healthy diseased individuals. Of great interest are reports bacteria play a role pathogenic cascade both Parkinson Alzheimer diseases. These neurodegenerative disorders involve misfolding endogenous proteins spreads from one region body to another manner analogous prions. The mechanisms how or is correlated with disease require elaboration. Microbial metabolites may influence neurodegeneration through promotion amyloid formation by human enhancing inflammatory responses neuronal amyloids. We review current knowledge concerning bacterial amyloids their potential cerebral aggregation neuroinflammation. propose term “mapranosis” describe process microbiota-associated proteopathy study made on health its infancy. This promising area for therapeutic intervention because there many ways alter microbial partners products, including proteins.

Language: Английский

Citations

337