Metabolomics,
Journal Year:
2019,
Volume and Issue:
15(3)
Published: March 1, 2019
When
foods
are
processed
or
cooked,
many
chemical
reactions
occur
involving
a
wide
range
of
metabolites
including
sugars,
amino
acids
and
lipids.
These
processes
often
lead
to
the
formation
volatile
aroma
compounds
that
can
make
food
tastier
may
introduce
off-flavours.
Metabolomics
tools
only
now
being
used
study
these
flavour
in
order
understand
better
beneficial
less
aspects
processing.To
provide
critical
overview
diverse
MS-based
studies
carried
out
recent
years
metabolomics
review
some
biochemical
properties
characteristics
different
groups
aroma-related
metabolites.
A
description
volatiles
from
foods,
their
relevant
sensorial
is
provided.
In
addition,
this
also
summarizes
precursors,
interconnections
between
Maillard
acid,
lipid,
carbohydrate
degradation
pathways.This
provides
new
insights
into
ingredients
describes
how
will
help
enable
us
produce,
preserve,
design
distribute
higher-quality
for
health
promotion
flavour.
Laboratory Medicine,
Journal Year:
2022,
Volume and Issue:
53(6), P. 545 - 551
Published: March 30, 2022
Metabolomics
is
a
field
of
systems
biology
that
draws
on
the
scientific
methods
other
groups
to
qualitatively
or
quantitatively
characterize
small
molecule
metabolites
in
organisms,
revealing
their
interconnections
with
state
organism
at
an
overall
relative
macroscopic
level.
Diabetic
kidney
disease
(DKD)
well
known
as
chronic
metabolic
disease,
and
metabolomics
provides
excellent
platform
for
its
clinical
study.
A
growing
number
metabolomic
analyses
have
revealed
individuals
DKD
disturbances
multiple
substances
bodies.
With
continuous
development
improvement
analysis
technology,
application
research
also
expanding.
This
review
discusses
recent
progress
early
diagnosis,
prognosis,
pathogenesis
level
vivo.
Angewandte Chemie International Edition,
Journal Year:
2016,
Volume and Issue:
55(44), P. 13658 - 13699
Published: Aug. 29, 2016
Abstract
Principle
has
it
that
even
the
most
advanced
super‐resolution
microscope
would
be
futile
in
providing
biological
insight
into
subcellular
matrices
without
well‐designed
fluorescent
tags/probes.
Developments
biology
have
increasingly
been
boosted
by
advances
of
chemistry,
with
one
prominent
example
being
small‐molecule
probes
not
only
allow
cellular‐level
imaging,
but
also
imaging.
A
majority,
if
all,
chemical/biological
events
take
place
inside
cellular
organelles,
and
researchers
shifting
their
attention
towards
these
substructures
help
fluorescence
techniques.
This
Review
summarizes
existing
target
within
a
single
organelle.
More
importantly,
organelle‐anchoring
strategies
are
described
emphasized
to
inspire
design
new
generations
probes,
before
concluding
future
prospects
on
possible
further
development
chemical
biology.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2015,
Volume and Issue:
3
Published: March 5, 2015
Metabolomics
comprises
the
methods
and
techniques
that
are
used
to
measure
small
molecule
composition
of
biofluids
tissues,
is
actually
one
most
rapidly
evolving
research
fields.
The
determination
metabolomic
profile
–the
metabolome-
has
multiple
applications
in
many
biological
sciences,
including
developing
new
diagnostic
tools
medicine.
Recent
technological
advances
nuclear
magnetic
resonance
(NMR)
mass
spectrometry
(MS)
significantly
improving
our
capacity
obtain
more
data
from
each
sample.
Consequently,
there
a
need
for
fast
accurate
statistical
bioinformatic
can
deal
with
complexity
volume
generated
studies.
In
this
review
we
provide
an
update
commonly
analytical
metabolomics,
starting
raw
processing
ending
pathway
analysis
biomarker
identification.
Finally,
integration
profiles
molecular
other
high
throughput
biotechnologies
also
reviewed.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 20, 2023
Metabolic
abnormalities
lead
to
the
dysfunction
of
metabolic
pathways
and
metabolite
accumulation
or
deficiency
which
is
well-recognized
hallmarks
diseases.
Metabolite
signatures
that
have
close
proximity
subject's
phenotypic
informative
dimension,
are
useful
for
predicting
diagnosis
prognosis
diseases
as
well
monitoring
treatments.
The
lack
early
biomarkers
could
poor
serious
outcomes.
Therefore,
noninvasive
methods
with
high
specificity
selectivity
desperately
needed.
Small
molecule
metabolites-based
metabolomics
has
become
a
specialized
tool
biomarker
pathway
analysis,
revealing
possible
mechanisms
human
various
deciphering
therapeutic
potentials.
It
help
identify
functional
related
variation
delineate
biochemical
changes
indicators
pathological
damage
prior
disease
development.
Recently,
scientists
established
large
number
profiles
reveal
underlying
networks
target
exploration
in
biomedicine.
This
review
summarized
analysis
on
potential
value
small-molecule
candidate
metabolites
clinical
events,
may
better
diagnosis,
prognosis,
drug
screening
treatment.
We
also
discuss
challenges
need
be
addressed
fuel
next
wave
breakthroughs.
