Applied Microbiology and Biotechnology, Journal Year: 2013, Volume and Issue: 97(21), P. 9291 - 9321
Published: Sept. 21, 2013
Language: Английский
Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(2), P. 116 - 211
Published: Jan. 1, 2015
This review of marine natural products for 2013 describes 1137 new compounds and reports structural revisions assignments absolute configurations previously described compounds. Included is a report the anticancer sponge metabolite PM060184 that has undergone remarkably rapid development from discovery in 2005 to commencement phase I clinical trials 2011.
Language: Английский
Citations
572
Marine Drugs, Journal Year: 2014, Volume and Issue: 12(2), P. 1066 - 1101
Published: Feb. 17, 2014
The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse hostile habitats, resulting the biosynthesis an array secondary metabolites with specific activities. Several these are high-value commercial products for pharmaceutical cosmeceutical industries. aim this review is outline paths natural discovery development, special focus on compounds successfully reached market particularly looking at approaches tackled by cosmetic companies succeeded marketing those products. main challenges faced during bioactives development programs were analyzed grouped three categories: biodiversity (accessibility resources efficient screening), supply technical (sustainable production knowledge mechanism action) (processes, costs, partnerships marketing). Tips surpass given order improve entry success rates highly promising current pipelines, highlighting what can be learned from successful unsuccessful stories applied novel and/or ongoing programs.
Language: Английский
Citations
518
Natural Product Reports, Journal Year: 2014, Volume and Issue: 31(2), P. 160 - 160
Published: Jan. 1, 2014
Covering: 2012. Previous review: Nat. Prod. Rep., 2013, 30, 237–323.
Citations
458
Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.
Language: Английский
Citations
447
Marine Drugs, Journal Year: 2014, Volume and Issue: 12(8), P. 4539 - 4577
Published: Aug. 19, 2014
Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily oldest animals are single best source of marine natural products. The present review presents a comprehensive overview source, taxonomy, country origin or geographical position, chemical class, and biological activity sponge-derived new products discovered between 2001 2010. data has been analyzed with view gaining an outlook on future trends opportunities in search for compounds their sources from sponges.
Language: Английский
Citations
398
Molecules, Journal Year: 2015, Volume and Issue: 20(4), P. 5286 - 5298
Published: March 24, 2015
Bacterial resistance is a rapidly escalating threat to public health as our arsenal of effective antibiotics dwindles. Therefore, there an urgent need for new antibiotics. Drug discovery has historically focused on bacteria growing in planktonic cultures. Many were originally developed target individual bacterial cells, being assessed vitro against microorganisms mode life. However, towards the end 20th century it became clear that many live complex communities called biofilms their natural habitat, and this includes habitats within human host. The biofilm life provides advantages microorganisms, such enhanced environmental stresses, including antibiotic challenge. community level provided by distinct from mechanisms operate at cellular level, cannot be overlooked development novel strategies combat infectious diseases. review compares levels light past present efforts. Future perspectives treatment biofilm-related diseases are explored.
Language: Английский
Citations
338
Nature Chemical Biology, Journal Year: 2014, Volume and Issue: 10(8), P. 640 - 647
Published: June 29, 2014
Language: Английский
Citations
279
Natural Product Reports, Journal Year: 2014, Volume and Issue: 31(10), P. 1425 - 1448
Published: Aug. 14, 2014
Covering: 2009 to 2013
Language: Английский
Citations
276
Marine Drugs, Journal Year: 2015, Volume and Issue: 13(7), P. 4044 - 4136
Published: June 30, 2015
This review presents the biological activity—antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity—of halogenated marine natural products discovered in past five years. Newly examples that do not report activity are included.
Language: Английский
Citations
252
Nature Communications, Journal Year: 2015, Volume and Issue: 6(1)
Published: March 31, 2015
Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by chemical complexity of dissolved matter (DOM). Here, using bioassay experiments ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simple produce exometabolites remarkable molecular structural diversity. Bacterial DOM is similar composition to naturally occurring sea water. An appreciable fraction bacterial properties are consistent with those ocean, indicating a dominant role for shaping nature DOM. The rapid production chemically complex persistent from biochemicals demonstrates positive feedback between primary formation. It appears diverse structurally persist environment largely driven bacteria. pump an important pathway sequestration, yet stability remain enigmatic. authors use investigate matter.
Language: Английский
Citations
249