The Lancet Infectious Diseases, Journal Year: 2016, Volume and Issue: 17(2), P. e30 - e41
Published: Dec. 12, 2016
Language: Английский
Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(2), P. 116 - 211
Published: Jan. 1, 2015
This review of marine natural products for 2013 describes 1137 new compounds and reports structural revisions assignments absolute configurations previously described compounds. Included is a report the anticancer sponge metabolite PM060184 that has undergone remarkably rapid development from discovery in 2005 to commencement phase I clinical trials 2011.
Language: Английский
Citations
574
Marine Drugs, Journal Year: 2014, Volume and Issue: 12(2), P. 1066 - 1101
Published: Feb. 17, 2014
The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse hostile habitats, resulting the biosynthesis an array secondary metabolites with specific activities. Several these are high-value commercial products for pharmaceutical cosmeceutical industries. aim this review is outline paths natural discovery development, special focus on compounds successfully reached market particularly looking at approaches tackled by cosmetic companies succeeded marketing those products. main challenges faced during bioactives development programs were analyzed grouped three categories: biodiversity (accessibility resources efficient screening), supply technical (sustainable production knowledge mechanism action) (processes, costs, partnerships marketing). Tips surpass given order improve entry success rates highly promising current pipelines, highlighting what can be learned from successful unsuccessful stories applied novel and/or ongoing programs.
Language: Английский
Citations
518
Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(11), P. 1562 - 1583
Published: Jan. 1, 2015
This review encompasses the synthesis and identification of recently detected natural atropisomers with potential therapeutic activity.
Language: Английский
Citations
501
Natural Product Reports, Journal Year: 2016, Volume and Issue: 33(3), P. 382 - 431
Published: Jan. 1, 2016
This review of marine natural products for 2014 describes 1378 new compounds and reports structural revisions or assignments absolute configuration previously reported compounds. Since 1965 MNP chemists have made ∼9000 collections worldwide yielding ∼25 700 MNPs. The rate discovery MNPs by region is examined in this review.
Language: Английский
Citations
430
Marine Drugs, Journal Year: 2014, Volume and Issue: 12(8), P. 4539 - 4577
Published: Aug. 19, 2014
Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily oldest animals are single best source of marine natural products. The present review presents a comprehensive overview source, taxonomy, country origin or geographical position, chemical class, and biological activity sponge-derived new products discovered between 2001 2010. data has been analyzed with view gaining an outlook on future trends opportunities in search for compounds their sources from sponges.
Language: Английский
Citations
398
Natural Product Reports, Journal Year: 2015, Volume and Issue: 32(7), P. 904 - 936
Published: Jan. 1, 2015
Many organisms team up with symbiotic microbes for defense against predators, parasites, parasitoids, or pathogens. Here we review the known defensive symbioses in animals and microbial secondary metabolites responsible providing protection to host.
Language: Английский
Citations
368
Molecules, Journal Year: 2015, Volume and Issue: 20(4), P. 5286 - 5298
Published: March 24, 2015
Bacterial resistance is a rapidly escalating threat to public health as our arsenal of effective antibiotics dwindles. Therefore, there an urgent need for new antibiotics. Drug discovery has historically focused on bacteria growing in planktonic cultures. Many were originally developed target individual bacterial cells, being assessed vitro against microorganisms mode life. However, towards the end 20th century it became clear that many live complex communities called biofilms their natural habitat, and this includes habitats within human host. The biofilm life provides advantages microorganisms, such enhanced environmental stresses, including antibiotic challenge. community level provided by distinct from mechanisms operate at cellular level, cannot be overlooked development novel strategies combat infectious diseases. review compares levels light past present efforts. Future perspectives treatment biofilm-related diseases are explored.
Language: Английский
Citations
338
Natural Product Reports, Journal Year: 2014, Volume and Issue: 31(10), P. 1425 - 1448
Published: Aug. 14, 2014
Covering: 2009 to 2013
Language: Английский
Citations
276
Marine Drugs, Journal Year: 2015, Volume and Issue: 13(7), P. 4044 - 4136
Published: June 30, 2015
This review presents the biological activity—antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity—of halogenated marine natural products discovered in past five years. Newly examples that do not report activity are included.
Language: Английский
Citations
252
Molecules, Journal Year: 2019, Volume and Issue: 24(22), P. 4182 - 4182
Published: Nov. 18, 2019
Seaweeds have received huge interest in recent years given their promising potentialities. Their antioxidant, anti-inflammatory, antitumor, hypolipemic, and anticoagulant effects are among the most renowned studied bioactivities so far, these been increasingly associated with content richness both primary secondary metabolites. Although metabolites a pivotal importance such as polysaccharides (fucoidans, agars, carragenans, ulvans, alginates, laminarin), data shown that some largely determines effective bioactive potential of seaweeds. Among metabolites, phenolic compounds feature prominently. The present review provides remarkable insights into seaweed research, specifically addressing its chemical composition, phytopharmacology, cosmetic applications.
Language: Английский
Citations
239