Marine natural products

Natural Product Reports, Journal Year: 2018, Volume and Issue: 35(1), P. 8 - 53

Published: Jan. 1, 2018

This review of 2016 literature describes the structures and biological activities 1277 new marine natural products structure revision absolute configuration previously reported MNPs. The chemical diversity 28 609 MNPs since 1957 is also investigated compared to that approved drugs.

Language: Английский

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A Review of the Microbial Production of Bioactive Natural Products and Biologics

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: June 20, 2019

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known natural products. Natural products have been a prolific source an inspiration for numerous medical agents with widely divergent chemical structures biological activities, including antimicrobial, immunosuppressive, anticancer, anti-inflammatory many which developed treatments potential therapeutic applications human diseases. Aside from products, the recent development recombinant DNA technology has sparked wide array biopharmaceutical proteins, offering significant advances in treating broad spectrum illnesses conditions. Herein, we will introduce diverse activities proteins that exploited valuable molecules medicine, agriculture insect control. In addition, explore past ongoing efforts along achievements robust promising microorganisms cell factories to biologically active molecules. Furthermore, review multi-disciplinary comprehensive engineering approaches directed at improving yields microbial production generating novel Throughout this article, suggest ways microbial-derived molecular entities their analogs could continue inspire new academia industry.

Language: Английский

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Marine natural products

Natural Product Reports, Journal Year: 2019, Volume and Issue: 36(1), P. 122 - 173

Published: Jan. 1, 2019

A comprehensive review of 1490 new MNPs including the first naturally occurring blue zwitterionic quinoids dactylocyanines A–H is presented.

Language: Английский

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Marine natural products

Natural Product Reports, Journal Year: 2017, Volume and Issue: 34(3), P. 235 - 294

Published: Jan. 1, 2017

Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 period January to December 2015) referring compounds isolated from microorganisms and phytoplankton, green, brown red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves other intertidal plants microorganisms. The emphasis is on new (1340 429 papers 2015), together relevant biological activities, source organisms country of origin. Reviews, biosynthetic studies, first syntheses, syntheses that lead revision structures or stereochemistries, have been included.

Language: Английский

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Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(8), P. 5619 - 5674

Published: Jan. 20, 2017

Naturally produced halogenated compounds are ubiquitous across all domains of life where they perform a multitude biological functions and adopt diversity chemical structures. Accordingly, diverse collection enzyme catalysts to install remove halogens from organic scaffolds has evolved in nature. Accounting for the different properties four halogen atoms (fluorine, chlorine, bromine, iodine) reactivity their substrates, enzymes performing biosynthetic degradative halogenation chemistry utilize numerous mechanistic strategies involving oxidation, reduction, substitution. Biosynthetic reactions range simple aromatic substitutions stereoselective C–H functionalizations on remote carbon centers can initiate formation complex ring Dehalogenating enzymes, other hand, best known removing man-made organohalogens, yet also function naturally, albeit rarely, metabolic pathways. This review details scope mechanism nature's dehalogenation enzymatic strategies, highlights gaps our understanding, posits new advances field might arise near future.

Language: Английский

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Strategies to diversify natural products for drug discovery

Medicinal Research Reviews, Journal Year: 2017, Volume and Issue: 38(4), P. 1255 - 1294

Published: Oct. 24, 2017

Natural product libraries contain specialized metabolites derived from plants, animals, and microorganisms that play a pivotal role in drug discovery due to their immense structural diversity wide variety of biological activities. The strategies greatly extend natural scaffolds through available chemical approaches offer unique opportunities access new series analogues, enabling the construction diverse product-like libraries. affordability these structurally molecules has been crucial step accelerating discovery. This review provides an overview various exploit compounds for product-based development, drawing upon examples illustrate each strategy.

Language: Английский

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Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications

Molecules, Journal Year: 2019, Volume and Issue: 24(22), P. 4182 - 4182

Published: Nov. 18, 2019

Seaweeds have received huge interest in recent years given their promising potentialities. Their antioxidant, anti-inflammatory, antitumor, hypolipemic, and anticoagulant effects are among the most renowned studied bioactivities so far, these been increasingly associated with content richness both primary secondary metabolites. Although metabolites a pivotal importance such as polysaccharides (fucoidans, agars, carragenans, ulvans, alginates, laminarin), data shown that some largely determines effective bioactive potential of seaweeds. Among metabolites, phenolic compounds feature prominently. The present review provides remarkable insights into seaweed research, specifically addressing its chemical composition, phytopharmacology, cosmetic applications.

Language: Английский

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A Systematic Cheminformatics Analysis of Functional Groups Occurring in Natural Products

Journal of Natural Products, Journal Year: 2019, Volume and Issue: 82(5), P. 1258 - 1263

Published: April 1, 2019

The two most striking features that discriminate natural products from synthetic molecules are their characteristic scaffolds and unique functional groups (FGs). In this study we systematically investigate the distribution of FGs in a cheminformatics perspective by comparing FG frequencies with those found average molecules. We thereby aim for identification produced living organisms. our analysis also include information about origins structures investigated, allowing us to link occurrence specific individual producing species. Our findings have potential being applied medicinal chemistry context concerning synthesis product-like libraries product-inspired fragment collections. results may be used support compound derivatization strategies design "non-natural" products.

Language: Английский

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Marine-Derived Pharmaceuticals - Challenges and Opportunities

Biomolecules & Therapeutics, Journal Year: 2016, Volume and Issue: 24(6), P. 561 - 571

Published: Oct. 31, 2016

Marine biosphere is the largest one of earth and harbors an enormous number different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production specific secondary metabolites important adaption mechanism marine organisms to survive sea. These possess biological activities which make them interesting as possible drugs for human. review presents sources, chemistry, pharmacology FDA approved derived pharmaceuticals arranged according their therapeutic indication. Four presently seven are used treatment cancer. Each another applicated viral diseases, chronic pain lower triglyceride level blood. Some other products interest diagnostic experimental tools. Besides, this article describes challenges drug development especially supply problem.

Language: Английский

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From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Aug. 6, 2018

Marine environment has demonstrated to be an interesting source of compounds with uncommon and unique chemical features on which the molecular modelling synthesis new drugs can based greater efficacy specificity for therapeutics. Cancer is a growing public health threat, despite advances in biomedical research technology, there urgent need development anticancer drugs. In this field, it estimated that more than 60% commercially available are natural biomimetic inspired. Among marine organisms, algae have been revealed one major sources origin, including those exhibiting antitumour cytotoxic potential by mediating specific inhibitory activities number key cellular processes, apoptosis pathways, angiogenesis, migration invasion both vitro vivo models, revealing their used as anti-cancer This review will focus bioactive molecules from potential, origin uses, special emphasis Sphaerococcus coronopifolius producer compounds.

Language: Английский

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