Highly fluorescent carbon dots as selective and visual probes for sensing copper ions in living cells via an electron transfer process

Biosensors and Bioelectronics, Journal Year: 2017, Volume and Issue: 97, P. 157 - 163

Published: May 19, 2017

Language: Английский

---

Regulation of Copper and Iron Homeostasis by Metal Chelators: A Possible Chemotherapy for Alzheimer’s Disease

Accounts of Chemical Research, Journal Year: 2015, Volume and Issue: 48(5), P. 1332 - 1339

Published: May 6, 2015

ConspectusWith the increase of life expectancy humans in more than two-thirds countries World, aging diseases are becoming frontline health problems. Alzheimer's disease (AD) is now one major challenges drug discovery, since, with exception memantine 2003, all clinical trials candidates failed over past decade. If we consider that loss neurons due to a high level oxidative stress produced by nonregulated redox active metal ions like copper linked amyloids different sizes, regulation homeostasis key target. The difficulty for large copper-carrier proteins directly extract from metalated might be considered as being at origin rupture AD brains. So, there an urgent need new specific chelators should able regulate ions, specially and iron, brains.As consequence concept, promoting excretion brain not desired. One favor ligands sinks (amyloids one) transfer these redox-active or copper-containing enzymes. Obviously, affinity ion sufficient criterion, but specificity ability release under biological conditions considered.Such approach still largely unexplored. requirements very (ability cross brain–blood barrier, lack toxicity, etc.), few chemical series were proposed, and, among them, biochemical data scarce. As matter fact, bioinorganic pharmacology represents less 1% articles dedicated research. part deals old rather toxic drug, clioquinol related analogs, do efficiently soluble amyloids.We have designed developed tetradendate such 21 PA1637 based on bis(8-aminoquinolines) chelation copper(II) then can upon reduction reducing agent. These studies contribute understanding physicochemical properties tetradentate compared bidentate clioquinol. ligands, PA1637, after selection nontransgenic mouse model monitor episodic memory, currently preclinical development.

Language: Английский

---

Four-repeat tauopathies

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 180, P. 101644 - 101644

Published: June 22, 2019

Language: Английский

---

Copper signalling: causes and consequences

Cell Communication and Signaling, Journal Year: 2018, Volume and Issue: 16(1)

Published: Oct. 22, 2018

Copper-containing enzymes perform fundamental functions by activating dioxygen (O

Language: Английский

---

S100 Proteins in Alzheimer’s Disease

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: May 16, 2019

S100 proteins are calcium-binding that regulate several processes associated with Alzheimer's disease (AD) but whose contribution and direct involvement in pathophysiology remains to be fully established. Due neuroinflammation AD patients, the levels of increased brain some S100s play roles related processing amyloid precursor protein (APP), regulation beta peptide (Aβ) Tau phosphorylation. found inclusions, either within plaques or as isolated S100-positive puncta, which suggests an active role formation aggregates. Indeed, interactions between aggregating Aβ indicate regulatory over aggregation process, may delay aggravate aggregation, depending on stage relative levels. Additionally, also known influence AD-related signaling pathways other cytokines. Recent evidence metal-ligation by influences trace metal homeostasis brain, particularly zinc, is a major deregulated process AD. Altogether, this strongly key players AD-linked physiopathological processes, we discuss review.

Language: Английский

---