International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11708 - 11708
Published: Oct. 28, 2021
Selenium
(Se)
is
an
essential
trace
element
in
the
body.
It
mainly
used
body
form
of
selenoproteins
and
has
a
variety
biological
functions.
Intestinal
diseases
caused
by
chronic
inflammation
are
among
most
important
threats
to
human
health,
there
no
complete
cure
at
present.
Due
its
excellent
antioxidant
function,
Se
been
proven
be
effective
alleviating
intestinal
such
as
inflammatory
bowel
(IBDs).
Therefore,
this
paper
introduces
role
tract
mechanism
their
involvement
mediation
diseases.
In
addition,
it
advantages
disadvantages
nano-Se
new
preparation
traditional
supplement
prevention
treatment
diseases,
so
provide
reference
for
further
exploration
interaction
between
selenium
health.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(13), P. 2140 - 2140
Published: June 22, 2022
Neurological
disorders
(NDs)
are
recognized
as
one
of
the
major
health
concerns
globally.
According
to
World
Health
Organization
(WHO),
neurological
main
causes
mortality
worldwide.
include
Alzheimer’s
disease,
Parkinson′s
Huntington′s
Amyotrophic
lateral
sclerosis,
Frontotemporal
dementia,
Prion
Brain
tumor,
Spinal
cord
injury,
and
Stroke.
These
diseases
considered
incurable
because
no
specific
therapies
available
cross
blood-brain
barrier
(BBB)
reach
brain
in
a
significant
amount
for
pharmacological
effect
brain.
There
is
need
development
strategies
that
can
improve
efficacy
drugs
circumvent
BBB.
One
promising
approaches
use
different
types
nano-scale
materials.
nano-based
have
ability
increase
therapeutic
effect,
reduce
toxicity,
exhibit
good
stability,
targeted
delivery,
drug
loading
capacity.
Different
shapes
nanomaterials
been
widely
used
treatment
disorders,
including
quantum
dots,
dendrimers,
metallic
nanoparticles,
polymeric
carbon
nanotubes,
liposomes,
micelles.
nanoparticles
unique
characteristics,
sensitivity,
selectivity,
BBB
when
nano-sized
particles,
imaging
studies
NDs.
In
this
review,
we
briefly
summarized
recent
literature
on
various
their
mechanism
action
disorders.
Archives of Toxicology,
Journal Year:
2024,
Volume and Issue:
98(3), P. 579 - 615
Published: Jan. 24, 2024
Abstract
This
article
provides
an
overview
of
the
background
knowledge
ferroptosis
in
nervous
system,
as
well
key
role
nuclear
factor
E2-related
2
(Nrf2)
regulating
ferroptosis.
The
takes
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
and
amyotrophic
lateral
sclerosis
(ALS)
starting
point
to
explore
close
association
between
Nrf2
ferroptosis,
which
is
clear
significant
importance
for
understanding
mechanism
neurodegenerative
diseases
(NDs)
based
on
oxidative
stress
(OS).
Accumulating
evidence
links
pathogenesis
NDs.
As
progresses,
damage
antioxidant
excessive
OS,
altered
expression
levels,
especially
inhibition
by
lipid
peroxidation
inhibitors
adaptive
enhancement
signaling,
demonstrate
potential
clinical
significance
detecting
identifying
targeted
therapy
neuronal
loss
mitochondrial
dysfunction.
These
findings
provide
new
insights
possibilities
treatment
prevention
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(3), P. 1381 - 1399
Published: Jan. 12, 2024
Abstract
Neurological
disorders
incidences
are
increasing
drastically
due
to
complex
pathophysiology,
and
the
nonavailability
of
disease‐modifying
agents.
Several
attempts
have
been
made
identify
new
potential
chemicals
combat
these
neurological
abnormalities.
At
present,
complete
abolishment
diseases
is
not
attainable
except
for
symptomatic
relief.
However,
dietary
recommendations
help
brain
development
or
improvement
increased
over
years.
In
recent
times,
cruciferous
vegetables
their
phytochemicals
identified
from
preclinical
clinical
investigations
as
neuroprotective
The
present
review
highlights
beneficial
effects
molecular
mechanisms
such
indole‐3‐carbinol,
diindolylmethane,
sulforaphane,
kaempferol,
selenium,
lutein,
zeaxanthin,
vitamins
against
including
Parkinson's
disease,
Alzheimer's
stroke,
Huntington's
autism
spectra
disorders,
anxiety,
depression,
pain.
Most
protect
by
eliciting
antioxidant,
anti‐inflammatory,
antiapoptotic
properties.
Regular
intake
may
benefit
prevention
treatment
diseases.
suggests
that
there
a
lacuna
in
identifying
efficacy
phytochemicals.
Therefore,
high‐quality
future
studies
should
firmly
establish
above‐mentioned
settings.
Journal of Alzheimer s Disease,
Journal Year:
2018,
Volume and Issue:
62(3), P. 1369 - 1379
Published: March 13, 2018
It
is
estimated
that
by
the
year
2050
there
will
be
more
than
1.5
billion
people
globally
over
age
of
65
years.
Aging
associated
with
changes
to
a
number
different
cellular
processes
which
are
driven
variety
factors
contribute
characteristic
decline
in
function
seen
across
multiple
physiological
domains/tissues
elderly
(including
brain).
Importantly,
aging
also
primary
risk
factor
for
development
neurodegenerative
disorders
such
as
Alzheimer’s
disease.
As
such,
an
urgent
need
provide
greater
understanding
both
pathogenesis
and
treatment
these
devastating
disorders.
One
key
becomes
dysregulated
participates
directly
indirectly
age-related
dysfunction,
metal
homeostasis
neurochemistry
metalloproteins,
basic
science
has
been
extensively
reviewed
past.
In
this
review,
we
focus
on
human
clinical
intervention
trials
have
conducted
approximately
last
four
decades
attempted
establish
efficacy
targeting
ions
AD.
Metallomics,
Journal Year:
2017,
Volume and Issue:
9(12), P. 1703 - 1734
Published: Jan. 1, 2017
Here,
we
critically
review
the
literature
on
capacity
of
organoselenium
compounds
to
mimic
selenoproteins
(particularly
GPx)
and
discuss
some
bottlenecks
in
field.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(38), P. 34725 - 34735
Published: Sept. 3, 2019
Huntington's
disease
(HD)
is
an
incurable
with
progressive
loss
of
neural
function,
which
influenced
by
epigenetic,
oxidative
stress,
metabolic,
and
nutritional
factors.
Targeting
inhibition
huntingtin
protein
aggregation
a
strategy
for
HD
therapy,
but
the
efficacy
unsatisfactory.
Studies
found
that
selenium
(Se)
levels
in
brain
are
insufficient
individuals,
while
improvement
Se
homeostasis
may
attenuate
neuronal
dysfunction.
In
this
study,
we
applied
nanoparticles
(NPs)
(Nano-Se)
therapy
regulating
HD-related
neurodegeneration
cognitive
decline
based
on
transgenic
models
Caenorhabditis
elegans
(C.
elegans).
At
low
dosages,
Nano-Se
NPs
significantly
reduced
death,
relieved
behavioral
dysfunction,
protected
C.
from
damages
stress
conditions.
The
molecular
mechanism
further
revealed
attenuated
inhibited
proteins,
downregulated
expression
histone
deacetylase
family
members
at
mRNA
levels.
results
suggested
has
great
potential
therapy.
conclusion,
about
how
protect
conditions
they
repair
functions
will
benefit
This
study
also
guide
rational
design
or
other
compounds
to
improve
future.
Nutrients,
Journal Year:
2018,
Volume and Issue:
10(10), P. 1466 - 1466
Published: Oct. 9, 2018
Selenium
is
essential
for
humans
and
the
deficit
of
Se
requires
supplementation.
In
addition
to
traditional
forms
such
as
salts,
amino
acids,
or
selenium-enriched
yeast
supplements,
next-generation
selenium
with
lower
risk
excess
supplementation,
are
emerging.
These
based
on
toxicity,
higher
bioavailability,
controlled
release,
zerovalent
nanoparticles
(SeNPs)
selenized
polysaccharides
(SPs).
This
article
aims
focus
existing
analytical
systems
dietary
supplement,
providing,
at
same
time,
an
overview
methods
available
forms.
The
supplements
evaluated
in
comparison
conventional/traditional
ones,
well
analysis
speciation
that
suitable
reveal
which
species
present
a
supplement.
Knowledge
gaps
further
research
potential
this
field
highlighted.
review
indicates
should
include
step
related
chemical
separation.
Such
would
allow
proper
characterization
forms/species,
including
molecular
mass/dimension,
substantiates
marketing
claims
main
advantages
these
new
ingredients.
