Published: Jan. 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
134
Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6687 - 6687
Published: Sept. 18, 2023
Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and oxide nanoparticles stand out as promising candidates for multitude applications. This article aims provide contemporary insights into the perspectives challenges regarding use medicine. It summarises biomedical potential copper-based nanoformulations, including progress early-stage research, evaluate mitigate toxicity nanomaterials. The discussion covers prospects nanomaterials context their successful clinical translation. also addresses safety concerns, emphasizing need assessments nanomedicines. However, attention is needed solve current such biocompatibility controlled release. Ongoing research collaborative efforts overcome these obstacles are discussed. analysis guidance safe effective integration practice, thereby advancing recent literature highlighted multifaceted associated with translation from laboratory clinic. In particular, remains formidable hurdle, requiring innovative ensure seamless human body. Additionally, achieving release therapeutic agents poses complex challenge that requires meticulous engineering precise design.
Language: Английский
Citations
67
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 121 - 121
Published: Jan. 16, 2025
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made effective drug design. Drug targeting aims ensure that acts only pathological area; it defined as ability accumulate selectively quantitatively target tissue or organ, regardless of chemical structure active substance method administration. With targeting, conventional, biotechnological gene-derived drugs body’s organs, tissues, cells can be transported specific regions. These systems serve carriers regulate timing release. Despite having many advantageous features, these have limitations thoroughly treating complex diseases such cancer. Therefore, combining with nanoparticle technologies imperative treat cancer at both local systemic levels effectively. The nanocarrier-based delivery involves encapsulating target-specific molecules into polymeric vesicular systems. Various (DDS) were investigated discussed this review article. first part passive systems, hydrogels, thermoplastics, microdevices transdermal-based second carrier nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles smart nanogels). third part, advantages discussed, finally, market research commercial used nanotechnological approaches was included.
Language: Английский
Citations
2
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10
Published: Sept. 2, 2022
In recent decades, research scientists, molecular biologists, and pharmacologists have placed a strong emphasis on cutting-edge nanostructured materials technologies to increase medicine delivery the central nervous system (CNS). The application of nanoscience for treatment neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), brain cancer, hemorrhage has potential transform care. Multiple studies indicated that nanomaterials can be used successfully treat CNS disorders in case neurodegeneration. Nanomedicine development cure degenerative inflammatory is critical. Nanoparticles may act drug transporter precisely target sick sub-regions, boosting therapy success. It important develop strategies penetrate blood–brain barrier (BBB) improve effectiveness medications. One probable tactics use different nanoscale materials. These nano-based pharmaceuticals offer low toxicity, tailored delivery, high stability, loading capacity. They also therapeutic effectiveness. A few examples many kinds forms been widely employed neurological include quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. unique qualities, including sensitivity, selectivity, ability traverse BBB when nano-sized particles, make these nanoparticles useful imaging NDs. Multifunctional carrying pharmacological medications serve two purposes: they medication distribution while enabling cell dynamics pharmacokinetic study. However, because wide-ranging clinical implications, safety concerns persist, limiting any translation. evidence using nanotechnology create systems could pass across deliver chemicals was examined this
Language: Английский
Citations
42
Polymers, Journal Year: 2023, Volume and Issue: 15(9), P. 2196 - 2196
Published: May 5, 2023
Neurodegenerative diseases are common, incurable neurological disorders with high prevalence, and lead to memory, movement, language, intelligence impairments, threatening the lives health of patients worldwide. The blood–brain barrier (BBB), a physiological between central nervous system peripheral blood circulation, plays an important role in maintaining homeostasis intracerebral environment by strictly regulating transport substances brain. Therefore, it is difficult for therapeutic drugs penetrate BBB reach brain, this affects their efficacy. Nanoparticles (NPs) can be used as drug carriers also known nanoparticle-based delivery systems (NDDSs). These not only increase stability but facilitate crossing through improve In article, we provided overview types administration routes NPs, highlighted preclinical clinical studies NDDSs neurodegenerative diseases, summarized combined strategies management diseases. Finally, prospects challenges recent basic research were discussed. Above all, provide inspiring strategy treatment
Language: Английский
Citations
40
Environmental Research, Journal Year: 2023, Volume and Issue: 232, P. 116290 - 116290
Published: June 7, 2023
Language: Английский
Citations
32
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 816 - 816
Published: Jan. 3, 2023
The spinal cord and the brain form central nervous system (CNS), which is most important part of body. However, injury (SCI) caused by external forces one difficult types neurological to treat, resulting in reduced or even absent motor, sensory autonomic functions. It leads reduction disappearance self-organizing nerve Currently, its incidence increasing each year worldwide. Therefore, development treatments for SCI urgently needed clinic. To date, surgery, drug therapy, stem cell transplantation, regenerative medicine, rehabilitation therapy have been developed treatment SCI. Among them, biomaterials that use tissue engineering bioscaffolds transport cells drugs injured site are considered promising option. In this review, we briefly introduce molecular mechanism summarize application repair regeneration various models there still limited evidence about with Finally, review will provide inspiration direction future study
Language: Английский
Citations
28
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114163 - 114163
Published: Aug. 14, 2024
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)
Published: Sept. 17, 2024
Abstract Spinal cord injury (SCI) results from various causes, including sports‐related incidents, degenerative cervical myelopathy, traffic accidents, and falls. SCI typically leads to sensory motor dysfunction even paralysis. Current treatments for include systemic administration of high‐dose steroids surgical decompression stabilization. However, excessive use glucocorticoids may increase susceptibility infections bleeding. The long‐term effect surgery intervention remains unclear, with ongoing debates regarding its timing, efficacy, safety. Therefore, innovative approaches are urgently needed alleviate secondary injuries promote spinal recovery. One emerging therapeutic approach is modulating the microenvironments achieve neuroprotection neurogenesis during Several biomaterials favorable physicochemical properties have been developed enhance effects by regulating microenvironments. This Review first discusses pathology then introduces biomaterials‐based regulatory strategies targeting microenvironmental components, anti‐inflammation, anti‐oxidation, reduction excitotoxicity, revascularization, neurogenesis, scar density reduction. Additionally, research clinical application prospects microenvironment regulation presented.
Language: Английский
Citations
8
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125281 - 125281
Published: Jan. 1, 2025
Language: Английский
Citations
1